Plain-English translation of NCT03917043 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new oral medication called to see if it is safe and how well it works in people with advanced solid tumors. The medication targets three specific proteins (FAK, ALK, and ROS1) that help cancer cells grow. Early laboratory studies show promise, so researchers want to test it in patients to find the right dose and understand any side effects.
Many patients with advanced cancers need new treatment options, especially those whose cancers have stopped responding to current drugs or who cannot tolerate them. This medication was designed to attack cancer cells in a new way, so this trial will help doctors understand whether it could offer hope to patients with limited options.
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You will take the medication as a pill by mouth at home, starting at a low dose that may gradually increase as the trial progresses. The trial has two main phases: first, researchers will find the safest and most effective dose by gradually increasing it in small groups of patients; then, a larger group will take the best dose found. Throughout the study, you will have regular clinic visits for blood tests, imaging scans, and checkups to monitor how you are responding and watch for any side effects. You will also need to provide a small tumor tissue sample (biopsy) before treatment begins to help researchers understand your specific cancer.
AI-generated summary from trial data · Aug 4, 2026 · Not medical advice
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