Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(347 sites) United States
Cancer Center at Saint Joseph's, Phoenix, Arizona University of Arkansas for Medical Sciences, Little Rock, Arkansas Kaiser Permanente-Anaheim, Anaheim, California Kaiser Permanente-Baldwin Park, Baldwin Park, California Kaiser Permanente-Bellflower, Bellflower, California Mercy Cancer Center - Carmichael, Carmichael, California Mercy San Juan Medical Center, Carmichael, California Mercy Cancer Center - Elk Grove, Elk Grove, California Kaiser Permanente-Fontana, Fontana, California Marin General Hospital, Greenbrae, California Kaiser Permanente South Bay, Harbor City, California Kaiser Permanente-Irvine, Irvine, California Tibor Rubin VA Medical Center, Long Beach, California Kaiser Permanente Los Angeles Medical Center, Los Angeles, California Los Angeles General Medical Center, Los Angeles, California USC / Norris Comprehensive Cancer Center, Los Angeles, California Kaiser Permanente West Los Angeles, Los Angeles, California UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California Kaiser Permanente-Ontario, Ontario, California Kaiser Permanente - Panorama City, Panorama City, California Kaiser Permanente-Riverside, Riverside, California Mercy Cancer Center - Rocklin, Rocklin, California Mercy Cancer Center - Sacramento, Sacramento, California University of California Davis Comprehensive Cancer Center, Sacramento, California Kaiser Permanente-San Diego Zion, San Diego, California UCSF Medical Center-Mount Zion, San Francisco, California UCSF Medical Center-Parnassus, San Francisco, California UCSF Medical Center-Mission Bay, San Francisco, California Kaiser Permanente-San Marcos, San Marcos, California Ridley-Tree Cancer Center, Santa Barbara, California Woodland Memorial Hospital, Woodland, California Kaiser Permanente-Woodland Hills, Woodland Hills, California Beebe South Coastal Health Campus, Millville, Delaware Helen F Graham Cancer Center, Newark, Delaware Medical Oncology Hematology Consultants PA, Newark, Delaware Christiana Care Health System-Christiana Hospital, Newark, Delaware Beebe Health Campus, Rehoboth Beach, Delaware George Washington University Medical Center, Washington D.C., District of Columbia UM Sylvester Comprehensive Cancer Center at Aventura, Aventura, Florida UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida UM Sylvester Comprehensive Cancer Center at Doral, Doral, Florida University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida Tampa General Hospital, Tampa, Florida Grady Health System, Atlanta, Georgia Emory Proton Therapy Center, Atlanta, Georgia Emory University Hospital Midtown, Atlanta, Georgia Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia Emory Saint Joseph's Hospital, Atlanta, Georgia Emory Decatur Hospital, Decatur, Georgia Emory Johns Creek Hospital, Johns Creek, Georgia Alton Memorial Hospital, Alton, Illinois Rush-Copley Medical Center, Aurora, Illinois Advocate Outpatient Center - Aurora, Aurora, Illinois Advocate Good Shepherd Hospital, Barrington, Illinois Illinois CancerCare-Bloomington, Bloomington, Illinois Illinois CancerCare-Canton, Canton, Illinois Illinois CancerCare-Carthage, Carthage, Illinois Northwestern University, Chicago, Illinois Rush MD Anderson Cancer Center, Chicago, Illinois University of Illinois, Chicago, Illinois University of Chicago Comprehensive Cancer Center, Chicago, Illinois Advocate Illinois Masonic Medical Center, Chicago, Illinois AMG Crystal Lake - Oncology, Crystal Lake, Illinois Carle at The Riverfront, Danville, Illinois Decatur Memorial Hospital, Decatur, Illinois Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois Illinois CancerCare-Dixon, Dixon, Illinois Advocate Good Samaritan Hospital, Downers Grove, Illinois Carle Physician Group-Effingham, Effingham, Illinois Crossroads Cancer Center, Effingham, Illinois Advocate Sherman Hospital, Elgin, Illinois Elmhurst Memorial Hospital, Elmhurst, Illinois Illinois CancerCare-Eureka, Eureka, Illinois NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois Illinois CancerCare-Galesburg, Galesburg, Illinois Western Illinois Cancer Treatment Center, Galesburg, Illinois Northwestern Medicine Cancer Center Delnor, Geneva, Illinois NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois Ingalls Memorial Hospital, Harvey, Illinois Advocate South Suburban Hospital, Hazel Crest, Illinois NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois AMG Libertyville - Oncology, Libertyville, Illinois Condell Memorial Hospital, Libertyville, Illinois Illinois CancerCare-Macomb, Macomb, Illinois Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois Loyola University Medical Center, Maywood, Illinois Edward Hospital/Cancer Center, Naperville, Illinois UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois Northwestern Medicine Oak Brook, Oak Brook, Illinois Advocate Christ Medical Center, Oak Lawn, Illinois Northwestern Medicine Orland Park, Orland Park, Illinois University of Chicago Medicine-Orland Park, Orland Park, Illinois Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois Advocate High Tech Medical Park, Palos Heights, Illinois Advocate Lutheran General Hospital, Park Ridge, Illinois Illinois CancerCare-Pekin, Pekin, Illinois OSF Saint Francis Radiation Oncology at Pekin, Pekin, Illinois Illinois CancerCare-Peoria, Peoria, Illinois OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria, Illinois Methodist Medical Center of Illinois, Peoria, Illinois OSF Saint Francis Medical Center, Peoria, Illinois Illinois CancerCare-Peru, Peru, Illinois Valley Radiation Oncology, Peru, Illinois Illinois CancerCare-Princeton, Princeton, Illinois Memorial Hospital East, Shiloh, Illinois Southern Illinois University School of Medicine, Springfield, Illinois Springfield Clinic, Springfield, Illinois Springfield Memorial Hospital, Springfield, Illinois Carle Cancer Center, Urbana, Illinois Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois Illinois CancerCare - Washington, Washington, Illinois Reid Health, Richmond, Indiana McFarland Clinic - Ames, Ames, Iowa UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa Saint Anthony Regional Hospital, Carroll, Iowa Saint Luke's Hospital, Cedar Rapids, Iowa Mercy Hospital, Cedar Rapids, Iowa Oncology Associates at Mercy Medical Center, Cedar Rapids, Iowa UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa Iowa Methodist Medical Center, Des Moines, Iowa UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa Broadlawns Medical Center, Des Moines, Iowa Mercy Medical Center - Des Moines, Des Moines, Iowa UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa Iowa Lutheran Hospital, Des Moines, Iowa Methodist West Hospital, West Des Moines, Iowa University of Kansas Cancer Center, Kansas City, Kansas The University of Kansas Cancer Center - Olathe, Olathe, Kansas University of Kansas Cancer Center-Overland Park, Overland Park, Kansas Salina Regional Health Center, Salina, Kansas University of Kansas Health System Saint Francis Campus, Topeka, Kansas University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas LSU Health Baton Rouge-North Clinic, Baton Rouge, Louisiana Our Lady of the Lake Physician Group, Baton Rouge, Louisiana Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana Mary Bird Perkins Cancer Center - Metairie, Metairie, Louisiana East Jefferson General Hospital, Metairie, Louisiana LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie, Louisiana Tulane University School of Medicine, New Orleans, Louisiana Ochsner Medical Center Jefferson, New Orleans, Louisiana Lafayette Family Cancer Center-EMMC, Brewer, Maine Massachusetts General Hospital Cancer Center, Boston, Massachusetts Brigham and Women's Hospital, Boston, Massachusetts Dana-Farber Cancer Institute, Boston, Massachusetts Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan Trinity Health Medical Center - Brighton, Brighton, Michigan Trinity Health Medical Center - Canton, Canton, Michigan Chelsea Hospital, Chelsea, Michigan Henry Ford Hospital, Detroit, Michigan McLaren Cancer Institute-Flint, Flint, Michigan Singh and Arora Hematology Oncology PC, Flint, Michigan Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan Mid-Michigan Physicians-Lansing, Lansing, Michigan University of Michigan Health - Sparrow Lansing, Lansing, Michigan Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan McLaren Cancer Institute-Macomb, Mount Clemens, Michigan McLaren Cancer Institute-Owosso, Owosso, Michigan Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan Minnesota Oncology - Burnsville, Burnsville, Minnesota Mercy Hospital, Coon Rapids, Minnesota Fairview Southdale Hospital, Edina, Minnesota Unity Hospital, Fridley, Minnesota Fairview Clinics and Surgery Center Maple Grove, Maple Grove, Minnesota Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota Saint John's Hospital - Healtheast, Maplewood, Minnesota Abbott-Northwestern Hospital, Minneapolis, Minnesota Hennepin County Medical Center, Minneapolis, Minnesota Monticello Cancer Center, Monticello, Minnesota North Memorial Medical Health Center, Robbinsdale, Minnesota Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota Regions Hospital, Saint Paul, Minnesota United Hospital, Saint Paul, Minnesota Saint Francis Regional Medical Center, Shakopee, Minnesota Lakeview Hospital, Stillwater, Minnesota Ridgeview Medical Center, Waconia, Minnesota Rice Memorial Hospital, Willmar, Minnesota Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin, Missouri Saint Francis Medical Center, Cape Girardeau, Missouri Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters, Missouri MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri Freeman Health System, Joplin, Missouri University of Kansas Cancer Center - Briarcliff, Kansas City, Missouri University of Kansas Cancer Center - North, Kansas City, Missouri University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri Washington University School of Medicine, St Louis, Missouri Siteman Cancer Center-South County, St Louis, Missouri Siteman Cancer Center at Christian Hospital, St Louis, Missouri Mercy Hospital Saint Louis, St Louis, Missouri Billings Clinic Cancer Center, Billings, Montana Benefis Sletten Cancer Institute, Great Falls, Montana Cancer Partners of Nebraska, Lincoln, Nebraska Comprehensive Cancer Centers of Nevada - Henderson, Henderson, Nevada OptumCare Cancer Care at Seven Hills, Henderson, Nevada Oncology Las Vegas - Henderson, Henderson, Nevada OptumCare Cancer Care at Charleston, Las Vegas, Nevada Radiation Oncology Centers of Nevada Central, Las Vegas, Nevada Radiation Oncology Centers of Nevada Southeast, Las Vegas, Nevada Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas, Nevada Oncology Las Vegas - Tenaya, Las Vegas, Nevada OptumCare Cancer Care at MountainView, Las Vegas, Nevada Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas, Nevada Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas, Nevada Summerlin Hospital Medical Center, Las Vegas, Nevada Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada OptumCare Cancer Care at Fort Apache, Las Vegas, Nevada Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas, Nevada Renown Regional Medical Center, Reno, Nevada New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire Solinsky Center for Cancer Care, Manchester, New Hampshire Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey Cooper Hospital University Medical Center, Camden, New Jersey Saint Barnabas Medical Center, Livingston, New Jersey Memorial Sloan Kettering Monmouth, Middletown, New Jersey Memorial Sloan Kettering Bergen, Montvale, New Jersey Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey Rutgers New Jersey Medical School, Newark, New Jersey Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township, New Jersey Sands Cancer Center, Canandaigua, New York Memorial Sloan Kettering Commack, Commack, New York Northwell Health Physicians Partners Radiation Medicine at Queens, Forest Hills, New York Memorial Sloan Kettering Westchester, Harrison, New York Northwell Health/Center for Advanced Medicine, Lake Success, New York Garnet Health Medical Center, Middletown, New York Memorial Sloan Kettering Cancer Center, New York, New York Queens Cancer Center, Rego Park, New York Wilmot Cancer Institute Radiation Oncology at Greece, Rochester, New York Highland Hospital, Rochester, New York University of Rochester, Rochester, New York Memorial Sloan Kettering Nassau, Uniondale, New York Wilmot Cancer Institute at Webster, Webster, New York Duke Cancer Center Cary, Cary, North Carolina Duke University Medical Center, Durham, North Carolina Duke Cancer Center Raleigh, Raleigh, North Carolina Wake Forest University Health Sciences, Winston-Salem, North Carolina Altru Cancer Center, Grand Forks, North Dakota Cleveland Clinic Akron General, Akron, Ohio Miami Valley Hospital South, Centerville, Ohio University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio Cleveland Clinic Foundation, Cleveland, Ohio Ohio State University Comprehensive Cancer Center, Columbus, Ohio Miami Valley Hospital, Dayton, Ohio Premier Blood and Cancer Center, Dayton, Ohio Miami Valley Hospital North, Dayton, Ohio Armes Family Cancer Center, Findlay, Ohio Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio North Coast Cancer Care, Sandusky, Ohio Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio Upper Valley Medical Center, Troy, Ohio University of Cincinnati Cancer Center-West Chester, West Chester, Ohio Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma Legacy Mount Hood Medical Center, Gresham, Oregon Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon UPMC Altoona, Altoona, Pennsylvania UPMC-Heritage Valley Health System Beaver, Beaver, Pennsylvania Crozer-Keystone Regional Cancer Center at Broomall, Broomall, Pennsylvania Carlisle Regional Cancer Center, Carlisle, Pennsylvania Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania Delaware County Memorial Hospital, Drexel Hill, Pennsylvania UPMC Hillman Cancer Center Erie, Erie, Pennsylvania UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania Crozer Regional Cancer Center at Brinton Lake, Glen Mills, Pennsylvania UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg, Pennsylvania Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania IRMC Cancer Center, Indiana, Pennsylvania UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown, Pennsylvania UPMC Cancer Center at UPMC McKeesport, McKeesport, Pennsylvania UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg, Pennsylvania UPMC Cancer Center - Monroeville, Monroeville, Pennsylvania UPMC Hillman Cancer Center in Coraopolis, Moon Township, Pennsylvania UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania UPMC-Saint Margaret, Pittsburgh, Pennsylvania UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania UPMC-Passavant Hospital, Pittsburgh, Pennsylvania UPMC-Saint Clair Hospital Cancer Center, Pittsburgh, Pennsylvania UPMC Cancer Center at UPMC Northwest, Seneca, Pennsylvania UPMC Uniontown Hospital Radiation Oncology, Uniontown, Pennsylvania Crozer-Chester Medical Center, Upland, Pennsylvania UPMC Washington Hospital Radiation Oncology, Washington, Pennsylvania Chester County Hospital, West Chester, Pennsylvania Reading Hospital, West Reading, Pennsylvania UPMC Memorial, York, Pennsylvania Avera Cancer Institute - Mitchell, Mitchell, South Dakota Avera Cancer Institute at Pierre, Pierre, South Dakota Avera Cancer Institute, Sioux Falls, South Dakota Parkland Memorial Hospital, Dallas, Texas UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas Tarrant County Hospital District/JPS Health Network, Fort Worth, Texas UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth, Texas UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas Audie L Murphy VA Hospital, San Antonio, Texas VCU Massey Cancer Center at Hanover Medical Park, Mechanicsville, Virginia Bon Secours Saint Francis Medical Center, Midlothian, Virginia Bon Secours Cancer Institute at Reynolds Crossing, Richmond, Virginia VCU Massey Cancer Center at Stony Point, Richmond, Virginia VCU Massey Comprehensive Cancer Center, Richmond, Virginia Legacy Salmon Creek Hospital, Vancouver, Washington West Virginia University Charleston Division, Charleston, West Virginia Langlade Hospital and Cancer Center, Antigo, Wisconsin ThedaCare Regional Cancer Center, Appleton, Wisconsin Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin Aurora Health Care Germantown Health Center, Germantown, Wisconsin Aurora Cancer Care-Grafton, Grafton, Wisconsin Bellin Memorial Hospital, Green Bay, Wisconsin Aurora BayCare Medical Center, Green Bay, Wisconsin Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin Marshfield Medical Center-Marshfield, Marshfield, Wisconsin Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin Medical College of Wisconsin, Milwaukee, Wisconsin Aurora Sinai Medical Center, Milwaukee, Wisconsin Marshfield Medical Center - Minocqua, Minocqua, Wisconsin Cancer Center of Western Wisconsin, New Richmond, Wisconsin Drexel Town Square Health Center, Oak Creek, Wisconsin Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin Aurora Cancer Care-Racine, Racine, Wisconsin Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin Aurora Medical Center in Summit, Summit, Wisconsin Aspirus Regional Cancer Center, Wausau, Wisconsin Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin Aurora West Allis Medical Center, West Allis, Wisconsin Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin Marshfield Medical Center - Weston, Weston, Wisconsin Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin Canada
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec, Quebec Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec Key details Collaborators
National Cancer Institute (NCI)
Enrollment target
~586 participants
Primary completion
November 2026
Last updated January 2026