A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma. — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(229 sites) United States
Southern Cancer Center, Mobile, Alabama Arizona Oncology Associates - Tuscon-Rusadill Road, Tucson, Arizona TOI - Clinical Research, Cerritos, California UCSF Fresno, Clovis, California UC San Diego Health Sciences, La Jolla, California UCLA Clinical Research Unit Hematology/Oncology, Santa Monica, California Rocky Mountain Cancer Centers (RMCC) - Boulder, Boulder, Colorado St. Mary's Hospital and Regional Medical Center - St. Mary's, Grand Junction, Colorado SCL Health Lutheran Medical Center, Greeley, Colorado Cancer Specialists of North Florida, Fleming Island, Florida Florida Cancer Specialists & Research Institute (FCS) - Fort Myers Cancer Center, Fort Myers, Florida Mayo Clinic - Cancer Clinical Research Office, Jacksonville, Florida Mayo Clinic, Jacksonville, Florida Miami Cancer Institute, Miami, Florida Florida Cancer Affiliates/Ocala Oncology - Clinic, Ocala, Florida BRCR Medical Center, INC, Plantation, Florida Florida Cancer Specialists, St. Petersburg, Florida Florida Cancer Specialists - Panhandle, Tallahassee, Florida H Lee Moffitt Cancer Center and Research Institute I, Tampa, Florida Florida Cancer Specialists & Research Institute (FCS) - Atlantis, West Palm Beach, Florida Kaiser Permanente Hawaii Moanalua Medical Center, Honolulu, Hawaii University of Chicago, Chicago, Illinois Illinois Cancer Specialists, Niles, Illinois June E. Nylen Cancer Center, Sioux City, Iowa The University of Kansas Cancer Center, Overland Park, Kansas University of Maryland, Baltimore, Maryland The office of Frederick P. Smith, MD, P.C., Chevy Chase, Maryland Mass General Cancer Center at Newton-Wellesley, Newton, Massachusetts University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan St. Joseph Mercy Hospital, Ypsilanti, Michigan Mayo Clinic - Rochester, Rochester, Minnesota Saint Louis University Cancer Center, St Louis, Missouri University Of Nebraska Medical Center, Omaha, Nebraska Astera Cancer Care, East Brunswick, New Jersey Astera Cancer Center, East Brunswick, New Jersey Regional Cancer Care Associates-Freehold, Freehold, New Jersey Hackensack University Medical John Theurer Cancer Center, Hackensack, New Jersey Regional Cancer Care Associates LLC - Howell, Howell Township, New Jersey Regional Cancer Care Associates LLC - Little Silver, Little Silver, New Jersey New Mexico Cancer Care Alliance, Albuquerque, New Mexico New York Oncology Hematology, P.C., Albany, New York Northwell Health/Monter Cancer Center, Lake Success, New York Weill Cornell Medicine-New York Presbyterian Hospital, New York, New York Columbia U - Herbert Irving Comprehensive Cancer Center, New York, New York Memorial Sloan-Kettering Cancer Center, New York, New York Hematology Oncology Associates of Rockland, P.C., Nyack, New York Messino Cancer Center, Asheville, North Carolina Levine Cancer Institute - Concord, Concord, North Carolina FirstHealth of the Carolinas, Pinehurst, North Carolina Regional Medical Oncology Center, Wilson, North Carolina Gabrail Cancer Center Research, Canton, Ohio Oncology Hematology Care (OHC), Inc. - Kenwood Office, Cincinnati, Ohio Willamette Valley Cancer Institute and Research Center - Oncology, Eugene, Oregon University of Pittsburgh Medical Center - Oncology, Pittsburgh, Pennsylvania Western Pennsylvania Hospital Hematology & Cellular Therapy, Pittsburgh, Pennsylvania Tennessee Oncology, PLLC, Chattanooga, Tennessee University of Tennessee Medical Center - Cancer Institute, Knoxville, Tennessee Sarah Cannon Research Institute, Nashville, Tennessee Texas Oncology - Amarillo, Amarillo, Texas Texas Oncology-Austin Midtown, Austin, Texas Texas Oncology - Medical City Dallas Pediatric Hematology, Dallas, Texas Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas The University of Texas MD Anderson Cancer Center, Houston, Texas Millennium Physicians - Oncology, Houston, Texas Texas Oncology, Plano, Texas Mays Cancer Center, San Antonio, Texas UT Health East Texas HOPE Cancer Center - Tyler, Tyler, Texas USO Texas Oncology - Tyler, Tyler, Texas Texas Oncology- Weslaco, Weslaco, Texas Utah Cancer Specialists/ IHO Corp, Salt Lake City, Utah Huntsman Cancer Institute; The University of Utah, Salt Lake City, Utah Peninsula Cancer Institute, Chesapeake, Virginia Virginia Cancer Specialists, Gainesville, Virginia Oncology and Hematology Associates of Southwest Virginia Inc., Roanoke, Virginia MC Rockwood Cancer Bl Specialty Ctr - North, Spokane, Washington Yakima Valley Memorial Hospital - North Star Lodge Cancer Center, Yakima, Washington Wheeling Hospital, Wheeling, West Virginia Australia
Royal Adelaide Hospital, Adelaide, South Australia Flinders Medical Centre, Bedford Park, South Australia Monash Health, Clayton, Victoria Barwon Health, University Hospital Geelong, Geelong, Victoria Hollywood Private Hospital, Nedlands, Western Australia GenesisCare - St Andrew's, Adelaide Peninsula Health - Frankston, Frankston Royal Hobart Hospital, Hobart Gold Coast University Hosptial, Southport Belgium
CHU Dinant Godinne UCL Namur, Yvoir, Namur Universitair Ziekenhuis Gent, Ghent, Oost-Vlaanderen UZ Leuven - Campus Gasthuisberg, Leuven, Vlaams Brabant Brazil
Hospital Haroldo Juacaba - Instituto do Cancer do Ceara, Ceará Hospital Santa Cruz, Curitiba HC-UFG - Hospital das CLINICAS da Universidade Federal de Go, Goiânia Association Hospital de Caridade de Iju, Ijuí Liga Norte Riograndense Contra o Cancer, Natal Hospital de Clinicas de Porto Alegre - Centro de Pesquisa Clinica, Porto Alegre Instituto D'Or de Pesquisa e Ensino- Recife, Recife Instituto de Psiquiatria - UFRJ, Rio de Janeiro Instituto Nacional de Câncer - INCA, Rio de Janeiro Fundacao Antonio Prudente - Hospital A.C.Camargo Cancer Center, São Paulo Hospital Alemao Oswaldo Cruz (HAOC), São Paulo Instituto D'or de Pesquisa e Ensino, São Paulo Instituto de Oncologia e Hematologia - HEMOMED, São Paulo Canada
University Health Network Princess Margaret Hospital, Toronto, Ontario Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec Sir Mortimer B Davis/Jewish General Hospital, Montreal, Quebec Nova Scotia Health Centre for Clinical Research, Nova Scotia Sunnybrook Health Sciences Centre Odette Cancer Centre, Ottawa China
Fujian Medical University Union Hospital, Fuzhou, Fujian The First Affiliated Hospital of Xiamen University, Xiamen, Fujian The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou The Second Affiliated Hospital Zhejiang University School of Medicine, Zhejiang, Hangzhou The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Henan Provincial People's Hospital, Zhengzhou, Henan Henan Cancer Hospital, Zhengzhou, Henan Hunan Cancer Hospital, Changsha, Hunan The First Bethune Hospital of Jilin University, Changchun, Jinlin The Affiliated Hospital of Qingdao University, Qingdao, Shandong Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai Municipality Shanxi Bethune Hospital, Taiyuan, Shanxi France
Centre Hospitalier Universitaire de Bordeaux-Hopital du Haut Leveque, Pessac, Aquitaine CHRU Brest Hôp Morvan, Brest, Brittany Region Institut Bergonie, Bordeaux, Gironde Centre Hosp Mulh Hop Emile Muller, Mulhouse, Haut-Rhin Centre Henri Becquerel, Rouen, Haute-Normandie CHU de Limoges Dupuytren, Limoges, Haute-Vienne CHU de Grenoble - Hopital Albe, La Tronche, Isere CHU de Nantes - Hematologie, Nantes, Loire-Atlantique CHRU de Lille Hop Claude Huriez, Lille, Nord Centre Hospitalier Le Mans, Le Mans, Sarthe Centre Hospitalier Universitaire D'Angers - Hématologie Clinique, Angers CHRU de Besançon- Hopital Jean Minjoz, Besançon
Germany
Diakoneo Diak Schwaebisch Hall gGmbH, Schwäbisch Hall, Baden-Wurttemberg Klinikum Der Universität München AöR, München, Bavaria Klinikum rechts der Isar der Technischen Universitat Muenche, München, Bavaria Universitätsmedizin Mainz, Mainz, Hesse Universitaetsklinikum Bonn AöR, Bonn, North Rhine-Westphalia Kliniken Maria Hilf GmbH, Mönchengladbach, North Rhine-Westphalia Städt. Krankenhaus Kiel, Kiel, Schleswig-Holstein Vivantes Klinikum am Urban Hämatologie und Onkologie, Berlin University Medical Center Schleswig Holstein, Kiel Hungary
Debreceni Egyetem Klinikai Központ, Debrecen, Hajdú-Bihar Semmelweis Egyetem Általános Orvostudományi Kar, Budapest Országos Onkológiai Intézet, Budapest Del-pesti Centrumkorhaz Orszagos Hematologiai és Infektologiai Intezet, Budapest Italy
AOU Federico II, Naples, Campania Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori IRCCS, Meldola, Forli-Cesena ASST Spedali Civili di Brescia, Brescia PO Garibaldi-Nesima, ARNAS Garibaldi, Catania Ospedale Vito Fazzi, ASL Lecce, Lecce IEO - Istituto Europeo di Oncologia, IRCCS, Milan Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, Milan Ospedale Niguarda, ASST Grande Ospedale Metropolitano Niguarda, Milan Ospedale San Gerardo, ASST di Monza, Monza Ospedale Civile S.Spirito, PO di Pescara, AUSL Pescara, Pescara Ospedale Infermi di Rimini, AUSL Rimini, Distretto di Rimini, Presidio di Rimini, Santarcangelo di Romagna e Novafeltria, Rimini Catholic University Of Sacred Heart, Roma Poland
Centrum Medyczne Pratia Poznan, Skórzewo, Greater Poland Voivodeship Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw, Masovian Voivodeship Pratia Onkologia Katowice, Katowice Pratia MCM Krakow, Krakow Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Slupsku Sp. z o.o., Słupsk MICS Centrum Medyczne Torun, Torun MTZ Clinical Research powered by Pratia, Warsaw Uniwersytecki Szpital Kliniczny im. J. Mikulicza-Radeckiego we Wroclawiu, Wroclaw Singapore
National Cancer Center Singapore, Singapore Tan Tock Seng Hospital, Singapore South Korea
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Seoul Teugbyeolsi [Seoul-T'ukp] Severance Hospital, Yonsei University Health System, Seoul, Seoul Teugbyeolsi [Seoul-T'ukp Samsung Medical Center, Seoul, Seoul Teugbyeolsi [Seoul-T'ukp Seoul National University Hospital, Seoul, Seoul Teugbyeolsi Pusan National University Hospital, Busan Gachon University Gil Medical Center, Incheon Ajou University Hospital, Suwon Spain
Hospital Universitari Vall d'Hebrón, Barcelona, Cataluny Hospital Costa del Sol, Marbella, Málaga Hospital Del Mar, Barcelona Hospital Virgen de la Arrixaca, El Palmar Hospital Univ. Infanta Leonor, Madrid Hospital Universitario La Paz, Madrid Clínica Universidad de Navarra, Madrid C.H. de Navarra, Pamplona Hospital Universitario de Salamanca, Salamanca Hospital Universitario Nuestra Señora de Valme, Seville Hospital Universitario Virgen De La Macarena, Seville Taiwan
Buddihist Tzu Chi Medical Foundation- Hualien Tzu Chi Hospital, Hualien City Chang Gung Medical Foundation - Kaohsiung Chang Gung Memorial Hospital - Hemato-Oncology, Kaohsiung City Taichung Veterans General Hospital, Taichung National Cheng Kung University Hospital, Tainan National Taiwan University Hospital, Taipei Turkey (Türkiye)
Ankara University Medical Faculty - Hematology, Ankara Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research, Ankara Gazi University Medical Faculty, Ankara Medipol Bagcilar Mega Hospital, Istanbul Ondokuz Mayis University Medical Faculty - Hematology, Samsun United Kingdom
Western General Hospital - Haematology, Edinburgh, Edinburgh, City of Imperial College Healthcare NHS Trust - Hammersmith Hospital, London, London City St Bartholomew's Hospital Barts Health NHS Trust, London, London, City of The Clatterbridge Cancer Centre NHS Foundation Trust - Clatterbridge Cancer Centre, Bebington Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital, Cornwell Beatson West of Scotland Cancer Centre, Glasgow Northwick Park Hospital Middlesex, United Kindgom, HA1 3UJ, Middlesex
Irmandade Santa Casa de Misericordia de Sao Paulo, São Paulo Peking University Third Hospital, Beijing
The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou Tongji Hospital of Tongji Medical College of HUST, Hangzhou Jiangxi Cancer Hospital, Nanchang Shandong Cancer Hospital, Shandong Tongji Hospital of Tongji University, Shanghai Sichuan Provincial People's Hospital, Sichuan Tianjin Medical University Cancer Institute & Hospital, Tianjin CHU de Clermont-Ferrand, site Estaing, Clermont-Ferrand
Centre Hospitalier Docteur Schaffner, Lens L'Hôpital Privé Confluent, Nantes L'hôpital Privé du Concluent, Nantes Hopital Saint Louis, Paris Centre Hospitalier - Hôpital de jour d'Hématologie, Périgueux Centre Hospitalier Universitaire de Poitiers, Poitiers CHU de Nancy Brabois, Vandœuvre-lès-Nancy Centre Hospitalier Bretagne Atlantique, Vannes Institut Gustave Roussy, Villejuif Hopital Henri Mondor - Hemopathies Lymphoides, Créteil, Île-de-France Region PU Campus Bio-Medico di Roma, Roma Regina Elena, Istituto Nazionale dei Tumori , IFO, IRCCS, Roma Azienda Ospedaliera Santa Maria di Terni, Terni Azienda Ospedaliera Ordine Mauriziano di Torino, Ospedale Umberto I di Torino, Torino Ospedale S.Giacomo Apostolo, PO Castelfranco Veneto, AULSS 2 Marca Trevigiana, Treviso Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI), Ospedale Maggiore, Trieste