Plain-English translation of NCT04390737 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a new drug called HH2853 to see if it can safely treat certain cancers — including specific lymphomas and solid tumors — in patients who have already tried other treatments without success. The study happens in two phases: first, researchers will find the right dose and check for safety, then they will test the medication in larger groups of patients with specific cancer types to see how well it works.
Many patients with certain lymphomas and advanced solid tumors run out of effective treatment options, and their cancers come back or stop responding to standard therapies. This trial exists to find out whether this new treatment could offer hope to those patients by targeting the genetic changes that drive their cancers.
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In Phase I, you would take the medication by mouth twice daily in 28-day cycles while researchers monitor your safety and adjust the dose. In Phase II (if you qualify for that stage), you would continue taking the medication on the same schedule while the team tracks how well it works against your specific cancer type. You will have regular clinic visits for blood tests, imaging scans, and check-ups to watch for side effects and see if the cancer is shrinking.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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