A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer — Stella
Phase 2 — Testing in a larger group (up to a few hundred people) to further evaluate safety and begin to assess effectiveness.
(121 sites) United States
Mayo Clinic - Scottsdale, Scottsdale, Arizona John Muir Clinical Research Center, Concord, California The Oncology Institute of Hope and Innovation, Glendale, California Marin Cancer Care, Greenbrae, California St Joseph Hospital of Orange, Orange, California Sansum Clinic, Santa Barbara, California Rocky Mountain Cancer Centers - Denver Midtwon, Denver, Colorado Boca Raton Regional Hospital, Boca Raton, Florida Florida Cancer Specialist South, Fort Myers, Florida Mayo Clinic Florida, Jacksonville, Florida Florida Cancer Specialists, West Palm Beach, Florida Cancer Care Center of Decatur, Cancer Care Specialists of IL, Decatur, Illinois Indiana University Melvin and Bren Simon Comprehensive Cancer, Indianapolis, Indiana Belgium
Imeldaziekenhuis General Hospital, Bonheiden VZW Algemeen Ziekenhuis AZ Klina, Brasschaat Institut Jules Bordet, Brussels GHDC (Grand Hopital de Charleroi), Charleroi Centres Hospitaliers Jolimont, La Louvière Universitaire Ziekenhuizen Leuven, Leuven AZ Delta Roeselare, Roeselare GasthuisZusters Antwerpen - Sint-Augustinus, Wilrijk Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert Canada
The Ottawa Hospital Cancer Centre, Ottawa Princess Margaret Cancer Centre, Toronto Germany
Charité - Universitätsmedizin Berlin, Berlin Universitaetsklinikum St. Josef-Hospital Bochum, Bochum Universitätsklinikum Bonn, Med. Klinik u. Poliklinik I, Bonn Klinikum Esslingen GmbH, Esslingen am Neckar Krankenhaus Nordwest GmbH - Institut Fuer Klinisch-Onkologische Forschung (IKF), Frankfurt am Main Klinikum der Johann Wolfgang Goethe-Universitaet Frankfurt, Frankfurt am Main Studiengesellschaft BSF, Halle Universitätsklinikum Hamburg-Eppendorf, Hamburg Hämatologisch-Onkologische Praxis Eppendorf, Hamburg Asklepios Klinik Altona, Hamburg Medizinische Hochschule Hannover, Hanover National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg SLK-Kliniken Heilbronn GmbH, Heilbronn
Spain
Complejo Hospitalario Universitario A Coruna, A Coruña Hospital Nuestra Senora de Sonsoles, Ávila Hospital Universitari Germans Trias - ICO Badalona, Badalona Hospital Universitari Vall d'Hebron, Barcelona Institut Clinic Hematolo/Oncologia- ICMHO, Hospital Clinic i Provincial de Barcelona, Barcelona Hospital de la Santa Creu i Sant Pau, Barcelona Hospital Universitario Reina Sofia, Córdoba Hospital General Universitario Gregorio Maranon, Madrid Clinica Universidad Navarra, Madrid Hospital Universitario Ramón y Cajal, Madrid Hospital Clinico San Carlos, Madrid Hospital Universitario Fundacion Jimenez Diaz, Madrid Hospital Universitario La Paz, Madrid
Sweden
Lunds Universitet - Medicinska Fakulteten (Lund University Faculty of Medicine), Lund Sodersjukhuset, Onkologiska Kliniken, Stockholm Karolinska Universitetssjukhuset Solna, Stockholm United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington Queen Elizabeth Hospital Birmingham-University Hospitals Birmingham NHS Foundation Trust, Birmingham Velindre NHS Trust, Velindre Cancer Centre, Cardiff Hull and East Yorkshire Hospitals NHS Trust - Castle Hill Hospital, Cottingham Dorset County Hospital NHS Foundation Trust - Dorset County Hospital, Dorchester Beatson West of Scotland Cancer Centre - Gartnavel Royal Hospital - NHS Greater Glasgow and Clyde, Glasgow St Bartholomew's Hospital-Barts Health NHS Trust, London University College London Hospitals NHS Foundation Trust, London Royal Free London NHS Foundation Trust, London Guy's and St Thomas' Hospital NHS Foundation Trust, London The Royal Marsden NHS Foundation Trust- Chelsea, London The Christie NHS Foundation Trust, Manchester
Key details Collaborators
Genentech, Inc.
Enrollment target
~327 participants
Primary completion
November 2026
University of Kansas Cancer Center, Westwood, Kansas
University of Louisville - James Graham Brown Cancer Center, Louisville, Kentucky Josephine Ford Cancer Center-Henry Ford Cancer Center, Detroit, Michigan Allina Health, Minneapolis, Minnesota Mayo Clinic Rochester, Rochester, Minnesota New York Oncology Hematology, P.C., Albany, New York Weill Cornell Medical College, New York, New York New York - Presbyterian Hospital - Columbia University Medical center, New York, New York Oncology Hematology Care Clinical Trials, Cincinnati, Ohio Willamette Valley Cancer Institute and Research Center, Eugene, Oregon Rhode Island Hospital, Providence, Rhode Island Hollings Cancer Center Medical University Of South Carolina, Charleston, South Carolina Sarah Cannon (Tennessee Oncology - Nashville), Nashville, Tennessee Sarah Cannon Research Institute (SCRI) Oncology Partners, Nashville, Tennessee Texas Oncology, P.A. - Austin, Austin, Texas Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas The University of Texas MD Anderson Cancer Center, Houston, Texas Texas Oncology-San Antonio Medical Center, San Antonio, Texas Texas Oncology - Northeast Texas, Tyler, Texas Virginia Cancer Specialists, Fairfax, Virginia Benaroya Research Institute at Virginia Mason, Seattle, Washington University of Washington, Seattle, Washington MultiCare Institute for Research & Innovation, Spokane, Washington Northwest Cancer Specialists P.C., Vancouver, Washington University of Wisconsin Carbone Cancer Center, Madison, Wisconsin Froedtert Hospital and Medical College of Wisconsin, Milwaukee, Wisconsin Staedtisches Krankenhaus Kiel gGmbH, Kiel
Universitaetsklinikum Leipzig AoeR, Leipzig Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz KoeR, Mainz Klinikum der Philipps-Universität Marburg, Marburg LMU Klinikum (Campus Großhadern) Medizinische Klinik Universität München, München Städtisches Klinikum München GmbH, Klinikum Neuperlach, München OhO Ostholstein Onkologie, Oldenburg in Holstein Prosper Hospital, Recklinghausen Robert-Bosch-Krankenhaus - Centrum fuer Tumorerkrankungen, Stuttgart Universitätsklinikum Ulm, Ulm Universitätsklinikum Würzburg, Würzburg Hospital Universitario HMN Sanchinarro, Centro Integral Oncologico Clara Campal (CIOCC), Madrid
Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda Hospital Regional Universitario Carlos Haya Malaga - Instituto de Investigacion Biomedica de Malaga, Málaga Complejo Hospitalario de Orense, Ourense Clinica Universitaria de Navarra, Pamplona Complejo Hospitalario de Navarra (CHN), Pamplona Hospital Universitario Marques De Valdecilla, Santander Complejo Hospitalario Universitario De Santiago De Compostela, Santiago de Compostela Hospital Universitario Virgen del Rocio - Hospital de la Mujer, Seville Consorcio Hospital General Valencia, Valencia Complexo Hospitalario Universitario de Vigo (CHUVI), Vigo Hospital Universitario Miguel Servet, Zaragoza The Newcastle upon Tyne Hospitals NHS Foundation Trust - Freeman Hospital, Newcastle upon Tyne
Churchill Hospital - Oxford University Hospitals NHS Foundation Trust, Oxford Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust, Preston University Hospital Southampton NHS Foundation Trust - Southampton General Hospital, Southampton The Royal Marsden NHS Foundation Trust, Sutton Torbay Hospital - South Devon Healthcare Nhs Foundation Trust, Lowes Bridge, Torquay