DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2) — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(138 sites) United States
Children's of Alabama, Birmingham, Alabama Phoenix Children's Hospital, Phoenix, Arizona Children's Hospital Los Angeles, Los Angeles, California Children's Hospital of Orange County Main Campus - Orange, Orange, California Packard Children's Hospital Stanford, Palo Alto, California UCSF Benioff Children's Hospital, San Francisco, California Children's Hospital Colorado, Aurora, Colorado Connecticut Children's Medical Center, Hartford, Connecticut Children's National Medical Center, Washington D.C., District of Columbia University of Florida Health, Gainesville, Florida Nicklaus Children's Hospital, Miami, Florida Arnold Palmer Hospital for Children, Orlando, Florida Johns Hopkins All Children's Hospital, St. Petersburg, Florida Children's Healthcare of Atlanta, Atlanta, Georgia Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois University of Chicago, Chicago, Illinois Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana University of Iowa Hospitals Clinics, Iowa City, Iowa Norton Children's Hospital, Louisville, Kentucky Maine Children's Cancer Program, Scarborough, Maine Dana-Farber Cancer Institute, Boston, Massachusetts University of Michigan - - C.S. Mott Children's Hospital, Ann Arbor, Michigan Children's Minnesota, Minneapolis, Minnesota Childrens MS Cncr Ctr Bld Dsr, Jackson, Mississippi St. Louis Children's Hospital, St Louis, Missouri University of Nebraska Medical Center, Omaha, Nebraska Albany Medical Center, Albany, New York New York University Langone Health, New York, New York Columbia University, New York, New York University of Rochester, Rochester, New York Duke Cancer Institute, Durham, North Carolina Cleveland Clinic Main Campus, Cleveland, Ohio Oregon Health Science University, Portland, Oregon Dell Children's Medical Center of Central Texas, Austin, Texas University of Texas Southwestern Medical Center, Dallas, Texas Texas Children's Hospital, Houston, Texas Seattle Children's Hospital, Seattle, Washington University of Wisconsin - Madison, Madison, Wisconsin Australia
Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland Perth Children's Hospital, Nedlands Women's and Children's Health Network, North Adelaide The Royal Children's Hospital - Children's Cancer Centre, Parkville Sydney Children's Hospital - Randwick, Randwick Children's Hospital at Westmead, Westmead Austria
Medizinische Universität Innsbruck, Innsbruck, Tyrol Medizinische Universität Wien, Vienna Belgium
Cliniques Universitaires Saint-Luc, Brussels Universitair Ziekenhuis Gent, Ghent Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven Brazil
Grupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), São Paulo Canada
Alberta Children's Hospital, Calgary, Alberta Stollery Children's Hospital, Edmonton, Alberta British Columbia Children's Hospital, Vancouver, British Columbia McMaster Children's Hospital, Hamilton, Ontario Children's Hospital London Health Sciences Centre, London, Ontario Children's Hospital of Eastern Ontario, Ottawa, Ontario CHU Sainte-Justine, Montreal, Quebec The Montreal Children's Hospital, Montreal, Quebec Centre Hospitalier de l'Université Laval et Centre Mère-Enfant Soleil, Québec SickKids - The Hospital for Sick Children, Toronto Czechia
Fakultní Nemocnice Brno - D?tská Nemocnice, Brno Motol University Hospital, Prague Denmark
Aarhus Universitetshospital, Aarhus, Central Jutland Rigshospitalet, Copenhagen Egypt
CCHE, Cairo, Cairo Governorate Finland
Helsingin yliopistollinen sairaala (HUS), Helsinki Tampereen Yliopistollinen Sairaala, Tampere France
Centre de Lutte contre le Cancer - Centre Oscar Lambret, Lille Hôpital de la Timone, Marseille Gustave Roussy, Villejuif Germany
Universitätsklinikum Freiburg, Freiburg im Breisgau, Baden-Wurttemberg Universitätsklinikum Augsburg, Augsburg, Bavaria Universitätsklinikum Erlangen, Erlangen, Bavaria Universitätsklinikum Würzburg, Würzburg, Bavaria Universitätsklinikum Frankfurt, Frankfurt am Main, Hesse Medizinische Hochschule Hannover, Hanover, Lower Saxony Universitaetsklinikum Essen, Essen, North Rhine-Westphalia Universitätsklinikum Leipzig, Leipzig, Saxony Charité Universitätsmedizin Berlin, Berlin Evangelische Klinikum Bethel (EvKB), Bielefeld Universitätsklinikum Hamburg-Eppendorf, Hamburg Universitätsklinikum Heidelberg, Heidelberg Universitätsklinikum Tübingen, Tübingen Greece
Aghia Sofia General Children's Hospital, Athens Athens General Children's Hospital, Athens Hungary
Semmelweis Egyetem Tűzoltó utcai II. Sz. Gyermekgyógyászati Kliniká, Budapest Ireland
Children's Health Ireland at Crumlin, Crumlin, Dublin Israel
Schneider Children's Medical Center of Israel, Petah Tikva The Edmond and Lily Safra Children's Hospital, Ramat Gan Italy
Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Milan Ospedale Pediatrico Bambino Gesù, Roma, Rome Ospedale Infantile Regina Margherita, Torino, Turin Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari, Bari Azienda Ospedaliera U. Meyer, Florence Istituto Giannina Gaslini, Genova Azienda Ospedaliera di Rilievo Nazional Santobono Pausilipon, Naples Azienda Ospedale Università di Padova, Padova Azienda Sanitaria Universitaria Friuli Centrale - P.O. Santa Maria della Misericordia, Udine Jordan
King Hussein Cancer Foundation - King Hussein Cancer Center, Amman, Muhafazat al-Asima Netherlands
Prinses Maxima Centrum Kinderoncologie, Utrecht New Zealand
Starship Paediatric Blood & Cancer Center, Grafton Norway
Universitetssykehuset Nord-Norge - Tromsø, Tromsø, Troms Oslo Universitetssykehus, Oslo Singapore
SingHealth Group - KK Women's and Children's Hospital, Singapore Slovenia
Univerzitetni Klinini Center Ljubljana, Ljubljana South Korea
Seoul National University Hospital, Seoul Severance Hospital, Seoul Spain
Hospital Universitario Cruces, Barakaldo Hospital Universitari Vall d'Hebrón, Barcelona Hospital Sant Joan de Déu Barcelona, Barcelona Hospital Infantil Universitario Niño Jesús, Madrid Hospital Universitario La Paz, Madrid Hospital Universitario Virgen del Rocío, Seville Hospital Universitari i Politècnic La Fe, Valencia Sweden
Drottning Silvias barn- och ungdomssjukhus, Gothenburg Skånes Universitetssjukhus - Lund, Lund Astrid Lindgrens Barnsjukhus Solna, Stockholm Switzerland
Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne Universitaets - Kinderspital Zürich, Zurich Taiwan
Taipei Medical University Hospital, Taipei Chang Gung Memorial Hospital - Linkou Branch, Taoyuan District United Kingdom
Birmingham Women's and Children's NHS Foundation Trust, Birmingham, England Leeds Teaching Hospital NHS Trust, Leeds, England Alder Hey Children's NHS Foundation Trust, Liverpool, England Manchester University NHS Foundation Trust, Manchester, England The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, England Great Ormond Street Hospital for Children, Oxford, England University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland NHS Greater Glasgow and Clyde, Glasgow, Scotland Sheffield Children's Hospital, Sheffield, South Yorkshire The Royal Marsden NHS Foundation Trust, Sutton, Surrey University Hospitals Bristol and Weston NHS Foundation Trust, Bristol
Key details Sponsor
Day One Biopharmaceuticals, Inc.
Collaborators
SIOPe Brain Tumor Group LOGGIC Consortium
Enrollment target
~400 participants
Primary completion
June 2027
Last updated March 2026
Cambridge University Hospitals NHS Foundation Trust, Cambridge
The Christie Hospital, Manchester
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