A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1) — StellaPhase 1 — Early testing in a small group of people (usually 20–80) to evaluate safety, determine safe dosage, and identify side effects.
Trial locations(54 sites)
United States
University of Colorado Anschutz Medical Campus, Aurora, Colorado Colorado Blood Cancer Institute, Denver, Colorado Local Institution - 0048, New Haven, Connecticut Mayo Clinic in Florida, Jacksonville, Florida University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami, Florida Local Institution - 0053, Chicago, Illinois Local Institution - 0030, Baltimore, Maryland Local Institution - 0038, Boston, Massachusetts Local Institution - 0046, Boston, Massachusetts University of Massachusetts Chan Medical School, Worcester, Massachusetts University of Massachusetts Chan Medical School, Worcester, Massachusetts University of Michigan, Ann Arbor, Michigan Henry Ford Medical Center - New Center One, Detroit, Michigan Mayo Clinic in Rochester, Minnesota, Rochester, Minnesota Washington University School of Medicine, St Louis, Missouri Local Institution - 0028, Omaha, Nebraska Atlantic Health System Overlook Medical Center, Summit, New Jersey NYU Langone Health, New York, New York Local Institution - 0054, New York, New York Icahn School of Medicine at Mount Sinai, New York, New York Columbia University Irving Medical Center, New York, New York Local Institution - 0055, New York, New York The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Cleveland Clinic, Cleveland, Ohio Local Institution - 0027, Columbus, Ohio UT Southwestern Medical Center, Dallas, Texas The University of Texas Health Science Center at Houston, Houston, Texas University of Texas MD Anderson Cancer Center, Houston, Texas Swedish Medical Center, Seattle, Washington Local Institution - 0057, Seattle, Washington Fred Hutchinson Cancer Center, Seattle, Washington Belgium
UZ Leuven, Leuven, Vlaams-Brabant France
Local Institution - 0043, Strasbourg, Alsace CHU Bordeaux Haut-Leveque, Pessac, Aquitaine CHU Montpellier Lapeyronie Hospital, Montpellier, Hérault Hopital Claude Huriez - CHU de Lille, Lille Centre Hospitalier Universitaire de Nice - Hôpital l'Archet, Nice Hôpital Saint-Louis, Paris Local Institution - 0052, Paris Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, Rennes Germany
Universitaetsklinikum Wuerzburg, Würzburg, Bavaria Universitaetsklinikum Koeln, Cologne, North Rhine-Westphalia Universitätsklinikum Leipzig, Leipzig, Saxony Universitaetsklinikum Magdeburg, Magdeburg, Saxony-Anhalt Charité - Universitaetsmedizin Berlin - Campus Bejnamin Franklin, Berlin Universitaetsklinikum Duesseldorf, Düsseldorf Universitaetsklinikum Erlangen, Erlangen Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Lazio Humanitas, Rozzano, Milano Spain
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona] Hospital Universitario Marqués de Valdecilla, Santander, Cantabria Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña] Hospital Universitario Reina Sofia, Córdoba H.R.U Málaga - Hospital General, Málaga Age range
18 Years and older
Last updated January 2026