ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(169 sites) United States
Community Cancer Institute, Clovis, California Compassionate Cancer Care Medical Group, Fountain Valley, California Local Institution - 0095, Fresno, California Cancer and Blood Specialty Clinic, Los Alamitos, California UCLA Hematology/Oncology - Westwood (Building 200 Suite 120), Los Angeles, California St. Joseph Hospital, Orange, California Ventura County Hematology Oncology Specialists, Oxnard, California John Muir Health - Behring Pavilion, Walnut Creek, California Local Institution - 0098, Fort Collins, Colorado Hartford Hospital (HH), Hartford, Connecticut Yale-New Haven Hospital, New Haven, Connecticut Halifax Health Medical Center, Daytona Beach, Florida Local Institution - 0230, Daytona Beach, Florida Florida Cancer Specialists - South, Fort Myers, Florida Baptist MD Anderson Cancer Center, Jacksonville, Florida Local Institution - 0224, Margate, Florida BRCR Global, Plantation, Florida Florida Cancer Specialists - North, St. Petersburg, Florida Advanced Research, Tamarac, Florida Moffitt Cancer Center, Tampa, Florida Local Institution - 0240, Honolulu, Hawaii Northwestern Memorial Hospital, Chicago, Illinois Orchard Healthcare Research Inc., Skokie, Illinois Northwest Cancer Centers, P.C., Dyer, Indiana Local Institution - 0232, Pikeville, Kentucky Our Lady of the Lake RMC, Baton Rouge, Louisiana Pontchartrain Cancer Center, Covington, Louisiana Local Institution - 0097, New Orleans, Louisiana American Oncology Partners, PA, Bethesda, Maryland Metro-Minnesota Community Clinical Oncology, Saint Louis Park, Minnesota Hattiesburg Clinic Hematology/Oncology, Hattiesburg, Mississippi John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center, Columbus, Ohio University of Tennessee Medical Center, Knoxville, Tennessee University of Texas MD Anderson Cancer Center, Houston, Texas VCU Health Adult Outpatient Pavillion, Richmond, Virginia Blue Ridge Cancer Care, Roanoke, Virginia Kadlec Clinic Hematology and Oncology, Kennewick, Washington Local Institution - 0213, Seattle, Washington Argentina
Centro Medico Barrio Parque, Buenos Aires Instituto Alexander Fleming, Buenos Aires Hospital Británico de Buenos Aires, Buenos Aires Australia
Blacktown Hospital, Blacktown, New South Wales Royal Prince Alfred Hospital, Camperdown, New South Wales Coffs Harbour Health Campus, Coffs Harbour, New South Wales Pindara Private Hospital, Gold Coast, Queensland Monash Health, Clayton, Victoria Austin Health, Heidelberg, Victoria Brazil
Hospital Universitario Walter Cantidio, Fortaleza, Ceará Hospital São Lucas da PUCRS, Porto Alegre, Rio Grande do Sul Hospital das Clinicas FMUSP, São Paulo Canada
Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta St. Paul's Hospital, Vancouver, British Columbia Victoria Hospital & Children's Hospital - London Health Sciences Centre, London, Ontario Sunnybrook Health Sciences Centre, Toronto, Ontario Chile
Enroll SpA, Santiago, Santiago Metropolitan FALP, Santiago, Santiago Metropolitan Clínica Inmunocel, Santiago, Santiago Metropolitan Bradfordhill, Santiago, Santiago Metropolitan China
Local Institution - 0109, Hefei, Anhui Local Institution - 0217, Beijing, Beijing Municipality Local Institution - 0030, Beijing, Beijing Municipality Local Institution - 0223, Chongqing, Chongqing Municipality Local Institution - 0096, Fuzhou Fujian, Fujian Local Institution - 0220, Xiamen, Fujian Local Institution - 0031, Guangzhou, Guangdong Local Institution - 0266, Shijiazhuang, Hebei Local Institution - 0038, Harbin, Heilongjiang Local Institution - 0194, Zhengzhou, Henan Local Institution - 0108, Wuhan, Hubei Local Institution - 0089, Changsha, Hunan Local Institution - 0032, Nanjing, Jiangsu Colombia
Hospital Pablo Tobon Uribe, Medellín, Antioquia Sociedad De Oncologia Y Hematologia Del Cesar, Valledupar, Cesar Department Fundación Cardiovascular de Colombia, Piedecuesta, Santander Department Instituto Médico de Alta Tecnología S.A.S - IMAT S.A.S, Montería Czechia
Fakultní nemocnice Brno Bohunice, Brno, Brno-město Fakultni nemocnice Ostrava, Ostrava, Moravian-Silesian Region Vseobecna fakultni nemocnice v Praze, Prague France
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet, Nice, Alpes-Maritimes CHU Bordeaux Haut-Leveque, Pessac, Aquitaine Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours, Indre-et-Loire Chu Grenoble Alpes, La Tronche, Isère Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandœuvre-lès-Nancy, Lorraine Centre Hospitalier Universitaire d'Angers, Angers, Maine-et-Loire Gustave Roussy, Villejuif, Val-de-Marne Hôpital Saint-Louis, Paris Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse Germany
Local Institution - 0261, Erding, Bavaria Local Institution - 0250, Kempten (Allgäu), Bavaria Gemeinschaftspraxis für Hämatologie und Onkologie Münster, Münster, North Rhine-Westphalia InVO Institut für Versorgungsforschung in der Onkologie, Koblenz, Rhineland-Palatinate Universitätsklinikum Leipzig, Leipzig, Saxony Universitätsklinikum Jena, Jena, Thuringia Praxis fur Hamatologie und Onkologie, Berlin Local Institution - 0028, Berlin Universitaetsklinikum Duesseldorf, Düsseldorf Local Institution - 0255, Lübeck Kliniken Ostalb, Stauferklinikum, Mutlangen Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher, Würzburg Greece
Local Institution - 0242, Pátrai, Achaḯa University Hospital of Patras, Pátrai, Achaḯa University General Hospital of Alexandroupoli, Alexandroupoli, Anatolikí Makedonía Kai Thráki General Hospital of Athens "G. Gennimatas", Athens, Attikí General Hospital of Athens "Laiko", Athens, Attikí University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA", Chaïdári, Attikí Hong Kong
Local Institution - 0034, Hksar Hungary
Heves Vármegyei Markhot Ferenc Oktatókórház és Rendelőintézet, Eger, Heves County Szabolcs Szatmár Bereg Vármegyei Oktatókórház, Nyíregyháza, Szabolcs-Szatmár-Bereg Semmelweis Egyetem, Budapest India
Local Institution - 0243, Ahmedabad, Gujarat Local Institution - 0273, Ahmedabad, Gujarat Local Institution - 0177, Bengaluru, Karnataka Local Institution - 0193, New Delhi, National Capital Territory of Delhi Local Institution - 0235, New Delhi, National Capital Territory of Delhi Local Institution - 0178, Bhubaneswar, Odisha Local Institution - 0185, Hyderabad Local Institution - 0186, New Delhi Italy
Fondazione Policlinico Tor Vergata, Rome, Lazio Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Lombardy ASST Grande Ospedale Metropolitano Niguarda, Milan, Milano Humanitas, Rozzano, Milano Azienda Ospedaliera Ordine Mauriziano di Torino, Turin, Piedmont Azienda Ospedaliera Universitaria Careggi, Florence, Tuscany IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna Grande Ospedale Metropolitano - Presidio Morelli, Reggio Calabria Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma, Verona Japan
Local Institution - 0123, Kitakyushu-shi, Fukuoka Local Institution - 0117, Sapporo, Hokkaido Local Institution - 0126, Amagasaki, Hyōgo Local Institution - 0120, Sagamihara, Kanagawa Local Institution - 0118, Sendai, Miyagi Local Institution - 0125, Ōsaka-sayama, Osaka Local Institution - 0121, Shimotsuga, Tochigi Local Institution - 0124, Nagasaki Local Institution - 0122, Osaka Local Institution - 0119, Tokyo Mexico
Centro de Investigacion Clinica de Oaxaca, Oaxaca City, Oaxaca Hematológica Alta Especialidad SC, consultorio 830, Huixquilucan Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City Unidad Médica Onco-hematológica, Puebla City Poland
Specjalistyczny Szpital im. dra Alfreda Sokołowskiego w Wałbrzychu, Wałbrzych, Lower Silesian Voivodeship Uniwersyteckie Centrum Kliniczne, Gdansk Pratia Onkologia Katowice, Katowice MTZ Clinical Research powered by Pratia, Warsaw Puerto Rico
Auxilio Mutuo Cancer Center, San Juan Local Institution - 0237, San Juan Spain
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona] Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet de Llobregat, Catalunya [Cataluña] Hospital Clinico de Valencia, Valencia, Valenciana, Comunitat Hospital Universitario Virgen Nieves, Granada Hospital La Princesa, Madrid Hospital Universitario Central de Asturias, Oviedo Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca Hospital Universitario Virgen Del Rocio, Seville
Key details Sponsor
Bristol-Myers Squibb
Enrollment target
~360 participants
Primary completion
June 2027
Age range
18 Years and older
Last updated March 2026
Interested in joining? Local Institution - 0083, Suzhou, Jiangsu
Local Institution - 0079, Nanchang, Jiangxi Local Institution - 0043, Changchun, Jilin Local Institution - 0048, Shenyang, Liaoning Local Institution - 0111, Qingdao, Shandong Local Institution - 0218, Shanghai, Shanghai Municipality Local Institution - 0216, Xi’an, Shanxi Local Institution - 0075, Chengdu, Sichuan Local Institution - 0103, Tianjin, Tianjin Municipality Local Institution - 0029, Hangzhou, Zhejiang Local Institution - 0281, Ningbo, Zhejiang Local Institution - 0033, Wenzhou, Zhejiang