Plain-English translation of NCT05957367 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a new medication called in combination with an existing cancer treatment called for people with advanced gastrointestinal stromal tumors (GIST). Researchers want to find the right dose of the medication and see if it helps slow or stop tumor growth when used together with . The study is being conducted across multiple medical centers.
Some people with advanced GIST stop responding to standard treatments or cannot tolerate them. This trial explores whether combining this medication with might offer a new option for patients whose tumors have progressed despite previous therapy.
You likely qualify if…
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You would take tablets by mouth in combination with in 28-day treatment cycles. The study involves two phases: first, researchers test increasing doses of the new medication to find the safest dose, then they expand the study to see how well it works. You would have regular visits with the research team for check-ups, blood tests, imaging scans, and a tumor biopsy if possible.
AI-generated summary from trial data · Aug 28, 2026 · Not medical advice
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