Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Participants With Metastatic Leiomyosarcoma (SaLuDo) — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(97 sites) United States
Mayo Clinic Hospital - Phoenix, Phoenix, Arizona Precision NextGen Oncology & Research Center, Beverly Hills, California Cedars-Sinai Medical Center, Los Angeles, California Norris Comprehensive Cancer Center, Los Angeles, California Sarcoma Oncology Center, Los Angeles, California Stanford University (Leland Stanford Junior University), Palo Alto, California University of Colorado Hospital - Anschutz Medical Campus, Aurora, Colorado Mayo Clinic - Jacksonville, Jacksonville, Florida Moffitt Cancer Center, Tampa, Florida Augusta University Georgia Cancer Center, Augusta, Georgia Massachusetts General Hospital, Boston, Massachusetts Dana-Farber Cancer Institute, Boston, Massachusetts University of Michigan, Ann Arbor, Michigan Mayo Clinic - Rochester, Rochester, Minnesota Washington University School of Medicine in St. Louis, St Louis, Missouri Memorial Sloan Kettering Cancer Center - New York, New York, New York Cleveland Clinic Main Campus, Cleveland, Ohio Oregon Health and Science University, Portland, Oregon University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, Pennsylvania Vanderbilt - Ingram Cancer Center, Nashville, Tennessee UT Southwestern Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas University of Texas MD Anderson Cancer Center, Houston, Texas Fred Hutchinson Cancer Center - Seattle Cancer Care Alliance (SCCA) Location, Seattle, Washington Austria
Universitaetsklinikum Graz - Universitätsklinik für Innere Medizin, Graz Medizinische Universität Innsbruck, Innsbruck Ordensklinikum Linz GmbH Barmherzige Schwestern, Linz Medizinische Universität Wien, Vienna Belgium
Universitair Ziekenhuis Bruseel, Jette, Brussels Capital Institut Jules Bordet, Anderlecht Cliniques Universitaires Saint-Luc, Brussels Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven France
Centre Léon Bérard, Lyon, Auvergne-Rhône-Alpes Centre Hospitalier Régional et Universitaire de Besançon - Hôpital Jean-Minjoz, Besançon, Doubs Institut de Cancérologie de l'Ouest - Angers, Angers, Pays de la Loire Region Centre Antoine Lacassagne, Nice, Provence-Alpes-Côte d'Azur Region Institut Bergonié, Bordeaux Centre de Lutte contre le Cancer - Centre Oscar Lambret, Lille Centre Hospitalier Universitaire Dupuytren 1, Limoges Hôspital de la Timone, Marseille Centre Hospitalier Universitaire de Poitiers, Poitiers Centre Eugène Marquis, Rennes Institut de Cancérologie de l'Ouest - Saint-Herblain - Site René Gauducheau, Saint-Herblain Gustave Roussy, Villejuif Germany
LMU Klinikum - Campus Großhadern, München, Bavaria Helios Klinikum Bad Saarow, Bad Saarow Universitatsklinikum Carl Gustav Carus Dresden, Dresden Medizinische Hochschule Hannover, Hanover Universitätsklinikum Heidelberg, Heidelberg Universitätsmedizin Mannheim, Manheim Universitätsklinikum Münster, Münster Universitätsklinikum Tübingen, Tübingen Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas, Rozzano, Milan Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Naples Centro di Riferimento Oncologico, Aviano Istituto Ortopedico Rizzoli, Bologna Azienda Ospedaliero-Universitaria di Bologna - Policlinico Sant Orsola-Malpighi, Bologna Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia, Candiolo Azienda Ospedaliero - Universitaria San Luigi Gonzaga, Orbassano Istituto Oncologico Veneto - IRCCS, Padova Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo Università Campus Bio-Medico di Roma, Roma Istituto Nazionale Tumori Regina Elena, Roma Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino Netherlands
Het Nederlands Kanker Instituut, Amsterdam, North Holland Leids Universitair Medisch Centrum (LUMC), Leiden, South Holland Poland
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw, Masovian Voivodeship Szpitale Pomorskie Spółka Z Ograniczoną Odpowiedzialnością, Gdynia, Pomeranian Voivodeship Portugal
Instituto Portugues De Oncologia De Lisboa Francisco Gentil, Lisbon, Lisbon District Unidade Local de Saúde de Coimbra, Coimbra Unidade Local de Saúde de Santo António, E.P.E - Hospital Geral de Santo António, Porto Instituto Português de Oncologia do Porto Francisco Gentil, Porto Spain
Complejo Hospitalario Universitario A Coruña, A Coruña Complejo Hospitalario Universitario de Santiago (CHUS), A Coruña Hospital de la Santa Creu i Sant Pau, Barcelona Hospital Universitari Vall d'Hebrón, Barcelona Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), Barcelona Hospital General Universitario Gregorio Marañón, Madrid Hospital Clínico San Carlos, Madrid Hospital Universitario Fundación Jiménez Díaz, Madrid Hospital Universitario La Paz, Madrid START Madrid - CIOCC - HM Sanchinarro, Madrid Hospital Universitario de Canarias, San Cristóbal de La Laguna Hospital Universitario Virgen del Rocío, Seville Hospital Clínico Universitario de Valencia, Valencia
Switzerland
Universitätsspital Basel, Basel Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne United Kingdom
University Hospital Birmingham NHS Foundation Trust, Birmingham Cambridge University Hospitals NHS Foundation Trust, Cambridge The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool University College London Hospitals NHS Foundation Trust, London The Royal Marsden NHS Foundation Trust, London The Christie NHS Foundation Trust, Manchester Oxford University Hospitals NHS Foundation Trust, Oxford Key details Enrollment target
~450 participants
Primary completion
August 2029
Age range
18 Years and older
Last updated April 2026
Interested in joining? Hospital Universitari i Politècnic La Fe, Valencia
Hospital Universitario Miguel Servet, Zaragoza