Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(114 sites) United States
Usc Norris Comprehensive Cancer Center, Los Angeles, California Sarcoma Oncology Research Center, Santa Monica, California University of Colorado Cancer Center, Aurora, Colorado Yale Cancer Center, New Haven, Connecticut Mayo Clinic - Jacksonville, Fl, Jacksonville, Florida University of Miami, Miami, Florida Emory Winship Cancer Institute, Atlanta, Georgia Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois University of Iowa Hospitals & Clinics- Holden Comprehensive Cancer Center, Iowa City, Iowa Johns Hopkins University, Baltimore, Maryland Dana-Farber Cancer Institute, Boston, Massachusetts Mayo Clinic - Rochester, Mn, Rochester, Minnesota The Washington University, St Louis, Missouri Nebraska Methodist Hospital, Omaha, Nebraska Memorial Sloan Kettering Cancer Center, New York, New York Duke University, Durham, North Carolina Cleveland Clinic, Cleveland, Ohio The Ohio State University Comprehensive Cancer Center, Columbus, Ohio Oregon Health & Science University Knight Cancer Institute, Portland, Oregon University of Pittsburgh Medical Center-Hillman Cancer Center, Pittsburgh, Pennsylvania Vanderbilt University Medical Center, Nashville, Tennessee The Univeristy of Texas Md Anderson Cancer Center, Houston, Texas Australia
Flinders Medical Centre, Bedford Park Chris O'Brien Lifehouse, Camperdown Chris O'Brien Lifehouse, Camperdown St Vincent'S Hospital Melbourne, Fitzroy Sir Charles Gairdner Hospital, Nedlands Princess Alexandra Hospital, Woolloongabba Belgium
Cliniques Universitaires St. Luc, Brussels Centre Multidisciplinaire de Oncologie Medicale, Liège Brazil
Liga Norte Riograndense Contra O Cancer, Natal, Rio Grande do Norte Hospital de Amor - Barretos, Barretos Hospital Das Clínicas Da Ufmg, Belo Horizonte Cepon - Centro de Pesquisas Oncologicas, Florianópolis Fundação Amaral Carvalho - Jaú/ Sp, Jaú Instituto Nacional Do Câncer - Inca, Rio de Janeiro Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo Impar Serviços Hospitalares S.A. - Hospital Nove de Julho, São Paulo Hospital A C Camargo, São Paulo Hospital Albert Einstein, São Paulo Canada
Alberta Health Services, Calgary, Alberta University Health Network, Toronto, Ontario Muhc Glen Site, Montreal, Quebec China
The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Shanghai Changzheng Hospital, Shang'ai, Shanghai Municipality Shanghai Ruijin Hospital, Shanghai, Shanghai Municipality Shanghai General Hospital, Shanghai, Shanghai Municipality West China Hopital of Sichuan University, Chengdu, Sichuan The Second Affiliated Hospital Zhejiang University School of Medical, Hangzhou, Zhejiang Beijing Cancer Hospital, Beijing Beijing Jishuitan Hospital, Beijing Henan Cancer Hospital, Guangzhou Denmark
Aarhus Universitetshospital, Aarhus Herlev & Gentofte Hospital, Herlev France
Institut Bergonié, Bordeaux Centre Oscar Lambret, Lille Hôpital Léon Bérard, Lyon Hopital de La Timone, Marseille INSTITUT de CANCEROLOGIE de l'Ouest, Saint-Herblain Iuct-Oncopole Institut Universitaire Du Cancer, Toulouse Institut Gustave Roussy, Villejuif Germany
Helios Klinikum Bad Saarow, Bad Saarow Charite Universitatsmedizin, Berlin Universitätsklinikum Carl Gustav Carus Dresden, Dresden Universitatsklinikum Hamburg-Eppendorf, Hamburg Universitätsmedizin Mannheim (Umm), Mannheim Ukm - Sarkom-Zentrum, Münster Universitaetsklinikum Ulm, Ulm Italy
Irccs Istituto Ortopedico Rizzoli, Bologna Irccs Fondazione Istituto Nazionale Dei Tumori, Milan San Luigi Gonzaga University Hospital of Turin, Orbassano Istituto Oncologico Veneto Iov - Irccs, Padova Aou Policlinico Paolo Giaccone, Palermo Ospedale Santo Stefano, Prato Policlinico Universitario Campus Biomedico, Roma Istituti Fisioterapici Ospitalieri (Ifo) - Istituto Nazionale Tumori Regina Elena (Ire), Roma Japan
Hokkaido Cancer Center, Sapporo, Hokkaido Kanazawa University Hospital, Kanazawa, Ishikawa-ken Nagoya University Hospital, Shōwaku, Nagoya-shi, Aichi Niigata University Medical and Dental General Hospital, Chūōku, Niigata City Oita University Hospital, Yufu-Shi, Oita Prefecture Osaka International Cancer Institute, Chūōku, Osaka-shi, Osaka National Cancer Center Hospital, Chuo-ku, Tokyo Fukushima Medical University Hospital, Fukushima Kyushu University Hospital, Higashi Cancer Institute Hospital of Jfcr, Koto-Ku, Tokyo Okayama University Hospital, Okayama Netherlands
Universitair Medisch Centrum Groningen (Umcg), Groningen Leids Universitair Medisch Centrum, Leiden Puerto Rico
Pan American Center For Oncology Trials, LLC, Rio Piedras South Korea
Seoul National University Hospital, Seoul Severance Hospital, Seoul Asan Medical Center, Seoul Samsung Medical Center, Seoul Spain
Hospital Universitario Valle de Hebrón - Vhio, Barcelona Hospital de La Santa Creu I Sant Pau, Barcelona Hospital de Bellvitge - Ico, L'Hospitalet de Llobregat Hospital General Universitario Gregorio, Madrid Hospital Universitario Fundación Jiménez Díaz, Madrid Hospital Universitario La Paz, Madrid Hospital Universitario Y Politecnico La Fe, Valencia Taiwan
National Taiwan University Hospital, Taipei Taipei Veterans General Hospital, Taipei United Kingdom
Western General Hospital, Edinburgh Royal Marsden Hospital, London Christie Hospital, Manchester Churchill Hospital, Oxford
Key details Sponsor
Servier Bio-Innovation LLC
Collaborators
Institut de Recherches Internationales Servier
Enrollment target
~136 participants
Primary completion
February 2028
Age range
18 Years and older
Last updated February 2026