Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(184 sites) United States
City of Hope(City of Hope National Medical Center, City of Hope Medical Center), Duarte, California Rocky Mountain Cancer Centers, LLP, Lone Tree, Colorado AdventHealth Hematology and Oncology, Orlando, Florida Winship Cancer Institute, Atlanta, Georgia The University of Kansas Cancer Center - Westwood, Westwood, Kansas Norton Cancer Institute - Audubon, Louisville, Kentucky Ochsner Clinic Foundation, New Orleans, Louisiana Tufts Medical Center, Boston, Massachusetts University of Michigan Hospital, Ann Arbor, Michigan Henry Ford Health System, Detroit, Michigan Minnesota Oncology Hematology, P.A., Maple Grove, Minnesota Atlantic Health System/Morristown Medical Center, Morristown, New Jersey Laura and Isaac Perlmutter Cancer Center at NYU Langone - Ambulatory Care Center, New York, New York Memorial Sloan Kettering Cancer Centers, New York, New York Oregon Health and Science University, Portland, Oregon Saint Francis Cancer Center, Greenville, South Carolina SCRI Oncology Partners, Nashville, Tennessee Texas Oncology - DFW, Dallas, Texas University of Texas Southwestern Medical Center, Dallas, Texas The Univerrsity of Texas MD Anderson Cancer Center, Houston, Texas Virginia Commonwealth University, VCU Health, Richmond, Virginia Argentina
Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires (caba), Buenos Altes Fundación ARS Médica, San Salvador de Jujuy, Jujuy Province Centro de Investigaciónes Clínicas - Clínica Viedma, Viedma, Río Negro Province Hospital Provincial Del Centenario, Rosario, Santa Fe Province Instituto Médico de la Fundación Estudios Clínicos, Rosario, Santa Fe Province CAIPO Centro para la Atención Integral del Paciente Oncológico, San Miguel de Tucumán, Tucumán Province Centro Médico en Oncología Clínica EXELSUS S.R.L, San Miguel de Tucumán, Tucumán Province Centro Médico Privado CEMAIC, Córdoba Belgium
Imelda VZW, Bonheiden, Antwerpen UZ Antwerpen, Edegem, Antwerpen UZ Leuven, Leuven, Vlaams-Brabant Brazil
Liga Norte Riograndense Contra O Cancer, Natal, Rio Grande do Norte Hospital de Clinicas de Porto Alegre - HCPA, Porto Alegre, Rio Grande do Sul Irmandade Da Santa Casa de Misericordia de Porto Alegre - ISCMPA, Porto Alegrev, Rio Grande do Sul Fundação Pio XII Hospital de Amor de Barretos, Barretos, São Paulo Fundação Doutor Amaral Carvalho - Hospital Amaral Carvalho, Jaú, São Paulo Fundação Faculdade Regional de Medicina de São José do Rio Preto (FUNFARME), São José do Rio Preto, São Paulo Hospital Nossa Senhora Da Conceição/Centro Integrado de Pesquisa em Oncologia CIPO-GHC, Porto Alegre Instituto Nacional de Cancer - INCA, Rio de Janeiro Canada
London Health Sciences Centre, London, Ontario Princess Margaret Cancer Centre - University Health Network, Toronto, Ontario Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec Chile
Servicios Médicos URUMED SpA, Rancagua, Libertador Gen Bernardo O Higgins Clinica Puerto Montt, Port Montt, Los Lagos Region James Lind Centro de Investigacion del Cancer, Temuco, Región de la Araucanía Centro de Investigacion y Especialidades Medicas (CDIEM), Santiago, Santiago Metropolitan Fundación Arturo López Pérez (FALP), Santiago, Santiago Metropolitan Oncovida, Santiago, Santiago Metropolitan Biocinetic Ltda, Santiago, Santiago Metropolitan Hospital Clinico Universidad de Chile, Santiago, Santiago Metropolitan China
The First Affiliated Hospital of USTC(Anhui Provincial Hospital), Hefei, Anhui Beijing Cancer Hospital, Beijing, Beijing Municipality The First Hospital of Lanzhou University, Lanzhou, Gansu Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Hunan Provincial People's Hospital, Changsha, Hunan Jilin Cancer Hospital, Changchun, Jilin Shandong Provincial Third Hospital, Jinan, Shandong Sichuan Cancer Hospital, Chengdu, Sichuan West China Hospital Sichuan University, Chengdu, Sichuan Zhongshan Hospital Fudan University, Shanghai Czechia
Fakultní nemocnice Brno, Interní hematologická a onkologická klinika, Brno Fakultni nemocnice Hradec Kralove, Klinika onkologie a radioterapie, Hradec Králové Fakultni nemocnice v Motole, Onkologicka klinika, Prague Finland
Docrates Cancer Center, Helsinki Comprehensive Cancer Center, Helsinki University Hospital, Helsinki Kuopio University Hospital, Kuopio France
CHU de Toulouse- (Toulouse University Hospital Center), Toulouse, Cedex 9 CHU Besancon, Besançon, Cedex CHU de Bordeaux - Hôpital Haut Leveque, Pessac, Cedex CHU Brest Hôpital de la Cavale Blanche, Brest CHU Estaing, Clermont-Ferrand Hospital Beaujon University, Clichy Hopital Henri Mondor, Créteil CHU Montepellier - Hôpital Saint Eloi, Montpellier Institut de Cancérologie de l'Ouest, Saint-Herblain Gustave Roussy, Villejuif Germany
Universitätsklinikum Freiburg - Klinik für Innere Medizin II,, Freiburg im Breisgau, Baden-Wurttemberg Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg, Heidelberg, Baden-Wurttemberg Universitätsklinikum Tübingen - Medizinische Universitätsklinik, Innere Medizin I, Tübingen, Baden-Wuttemberg LMU Universitätsklinikum München, Campus Großhadern, Medizinische Klinik und Poliklinik III - Hämatologie und Onkologie, München, Bavaria Krankenhaus Nordwest - Institut für Klinisch-Onkologische Forschung (IFK), Frankfurt am Main, Hesse Medizinische Hochschule Hannover - Klinik Fur Gastroenterologie, Hepatologie, Infektiologie und Endokrinologie, Hanover, Nieder-Sachsen Technische Universität Dresden Medizinische Fakultät Carl Gustav Carus, Dresden, Saxony Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Medizinische Klinik I (MKI), Lübeck, Schleswig-Holstein Charité - Universitätsmedizin Berlin - Campus Virchow Klinikum, Medizinische Klinik mit Schwerpunkt Hamatologie und Tumorimmunologie, Berlin Asklepios Tumorzentrum Hamburg, Asklepios Klinik Altona - Onkologie und Palliativmedizin mit Sektionen Hamatologie und Rheumatologie, Hamburg India
KLES Dr Prabhakar Kore Hospital and Medical Research Centre, Belagavi, Karnataka Tata Memorial Hospital, Mumbai, Maharashtra Chopda Medicare & Research Centre Pvt. Ltd - Magnum Heart Institute, Nashik, Maharashtra AIG Hospitals (A Unit of Asian Institute of Gastroenterology), Hyderabad, Telangana Pi Health Cancer Hospital, Hyderabad, Telangana Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi, Uttar Pradesh Max Super Speciality Hospital - Saket (a unit of Devki Devi foundation), New Delhi Rajiv Gandhi Cancer Institute And Research Centre, New Delhi Israel
Rambam Health Care Campus, Haifa The Hadassah University Medical Center, Ein Kerem Hospital, Jerusalem Rabin Medical Center, Bellinson Hospital, Petah Tikva The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, HaMerkaz Tel Aviv Sourasky Medical Center (Ichilov), Tel Aviv Italy
Azienda Ospedaliero Universitaria di Cagliari Presidio Ospedaliero Duilio Casula, Monserrato, Cagliari Instituo di Candiolo, Fondazione del Piemonte per l'Oncologia (IRCCS), Candiolo, Torino IRCCS Ospedale Policlinico San Martino, Genova Fondazione IRCCS Istituto Nazionale per lo studio e la cura dei Tumori, Milan AOU dell'Universit~ degli Studi della Campania Luigi Vanvitelli, Naples Veneto Institute of Oncology IOV - I.R.C.C.S., Padova Azienda Ospedaliero - Universitaria Pisana, Pisa Fondazione Policlinico Universitario Gemelli-IRCCS, Roma Istituto Clinico Humanitas, Rozzano Azienda Sanitaria Universitaria Friuli Centrale - P.O. S. Maria della Misericordia, Udine Azienda Ospedaliera Universitaria Integrata Verona, Verona Japan
Aichi Cancer Center, Nagoya, Aichi-ken Chiba Cancer Center, Chiba, Chiba National Cancer Center Hospital East, Kashiwa, Chiba National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime National Hospital Organization Kyushu Cancer Center, Fukuoka, Fukuoka Hokkaido University Hospital, Sapporo, Hokkaidô Kanazawa University Hospital, Kanazawa, Ishikawa-ken Kagoshima University Hospital, Kagoshima, Kagoshima-ken Kanagawa Cancer Center, Yokohama, Kanagawa Kyoto University Hospital, Kyoto, Kyôto Mie University Hospital, Tsu, Mie-ken Tohoku University Hospital, Sendai, Miyagi Niigata University Medical and Dental Hospital, Niigata, Niigata
Portugal
Unidade Local de Saude de Almada-Seixal, E.P.E. - Hospital Garcia de Orta, Almada Unidade Local de Saude de Coimbra, EPE - Hospitais da Universidade de Coimbra, Coimbra Unidade Local de Saúde de São José - Hospital de Santo António dos Capuchos, Lisbon Champalimaud Clinical Center, Lisbon Instituto Português de Oncologia Do Porto Francisco Gentil, EPE, Porto Puerto Rico
Hospital Oncologico, Puerto Rico Medical Center, Rio Piedras Romania
Spital Clinic Judetean de Urgenta Bihor, Oradea, Bihor County Centrul De Oncologie "SF. Nectarie" S.R.L., Craiova, Dolj Institutul Clinic Fundeni, Bucharest Centrul de Oncologie Euroclinic SRL, Iași Serbia
University Clinical Center of Serbia, Clinic for Gastroenterohepatology, Belgrade Military Medical Academy, Clinic for Gastroenterology and Hepatology, Belgrade Oncology Institute of Vojvodina, Internal Oncology Clinic, Kamenitz South Korea
CHA Bundang Medical Center, CHA University, Bundang-Gu, Seongnam-Si, Gyeonggi-do National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do Pusan National University Hospital, Busan Korea University Anam Hospital, Seoul Seoul National University Hospital, Seoul Severance Hospital, Yonsei University Health System, Seoul Hanyang University Seoul Hospital, Seoul Asan Medical Center, Seoul Samsung Medical Center, Seoul Korea University Guro Hospital, Seoul Spain
Complejo Hospitalario Universitario de Santiago -Hospital Clinico Universitario de Santiago, Santiago de Compostela, A Coruna Vall d'Hebron Institute of Oncology/Hospital Universitari de Vall d'Hebron, Barcelona Hospital Universitario Reina Sofia, Córdoba Hospital Universitario Fundacion Jimenez Diaz, Madrid Hospital Universitario 12 de Octubre, Madrid Hospital Universitario La Paz, Madrid Hospital Regional Universitario de Malaga, Málaga Clinica Universidad de Navarra, Pamplona Hospital Universitario Virgen Macarena, Seville Hospital Universitario y Politecnico La Fe, Valencia Hospital Universitario Miguel Servet, Zaragoza Sweden
Onkologiska mottagningen, Sahlgrenska Universitetssjukhuset, Gothenburg Cancerstudieenheten Huddinge, Karolinska Universitetssjukhuset Huddinge, Huddinge Onkologiska mottagningen, Skånes Universitetssjukhus Malmö, Malmo Taiwan
Kaohsiung Medical University - Chung-Ho Memorial Hospital, Kaohsiung City Chang Gung Memorial Hospital Kaohsiung Branch of the Chang Gung Medical Foundation, Kaohsiung City National Cheng Kung University Hospital, Tainan National Taiwan University Cancer Center, Taipei Chang Gung Memorial Hospital Linkou Branch of the Chang Gung Medical Foundation, Taoyuan District Turkey (Türkiye)
Istanbul University Cerrahpasa Medical Faculty Hospital/Clinical Research Center, Istanbul, Fatih Hacettepe University Cancer Institute, Ankara, Sihhiye Akdeniz University Medical Faculty Hospital, Antalya Trakya University Faculty of Medicine, Edirne United Kingdom
Mount Vernon Cancer Centre, London, England NHS Foundation Trust Royal Marsden Hospital, London, England The Christie NHS Foundation Trust, Manchester, England Royal Marsden Hospital NHS Foundation Trust, Surrey, England Western General Hospital, Edinburgh Cancer Centre, Edinburgh, Scotland
Key details Sponsor
Jazz Pharmaceuticals
Enrollment target
~286 participants
Primary completion
December 2028
Age range
18 Years and older
Last updated March 2026
Interested in joining? Osaka Prefectural Hospital Organization Osaka International Cancer Institute, Osaka, Osaka
The University of Tokyo Hospital, Bunkyo-ku, Tokyo National Cancer Center Hospital, Chuo-Ku, Tokyo The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Koto-Ku, Tokyo Kyorin University Hospital, Mitaka-shi, Tokyo Yamaguchi University Hospital, Ube-Shi, Yamaguchi Osaka University Hospital, Suita-Shi, Ôsaka