Receive one of two doses of clot-busting medication during a stroke emergency

Back to Acute Ischemic Stroke AIS trials

Recruiting

What is this trial?

This trial is testing whether a lower dose of — a medication that dissolves blood clots in the brain during a stroke — works as well as the standard dose. Stroke doctors around the world are already using this medication instead of older alternatives, but researchers want to know if giving less of it might be just as effective while potentially being safer for patients.

A previous study showed that a lower dose of an older clot-busting medication worked just as well as the standard dose in some patients. This trial is testing whether this medication can also work at a lower dose, which could reduce side effects while maintaining the same benefit.

Do you qualify?

You likely qualify if…

you have been diagnosed with an acute ischemic stroke (a stroke caused by a blood clot) and arrive at the hospital within 4.5 hours of when your symptoms started or when you were last known to be well
you have symptoms serious enough that your doctor thinks you could benefit from clot-busting medication
you are able to provide informed consent (or your legally authorized representative can do so)
you may have relative contraindications that your doctor would normally be cautious about, but your doctor believes you could still benefit from treatment

You likely don't qualify if…

you are actively bleeding or have a bleeding disorder
you have had recent brain surgery, head trauma, or bleeding in or around your brain
you have a very minor stroke with no serious symptoms
you have any absolute contraindication to clot-busting therapy according to your country's medical guidelines

What participation looks like

If you qualify, you will be randomly assigned to receive one of two doses of the clot-busting medication as a single injection into your vein within minutes of arriving at the hospital. The medication is given very quickly (over 10–20 seconds). Doctors will then monitor you closely in the hospital to see how well the treatment works and watch for any side effects. Your participation focuses on this emergency treatment; specific follow-up visits and timeline will depend on your hospital's protocols and your individual recovery.

Testing two doses of clot-busting medication for acute stroke

What is this trial?

Do you qualify?

What participation looks like

Trial locations(24 sites)