A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP) — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(190 sites) United States
AllerVie Clinical Research, Birmingham, Alabama University of Alabama at Birmingham, Birmingham, Alabama Keck Medicine of USC, Arcadia, California University of California, Irvine, Irvine, California DaVinci Research LLC, Roseville, California Breathe Clear Institute, Torrance, California Colorado ENT & Allergy, Colorado Springs, Colorado Orlando ENT & Allergy, Orlando, Florida NuLine Clinical Trial Center, Pompano Beach, Florida University of South Florida, Tampa, Florida Treasure Valley Medical Research, Boise, Idaho Entopy Research LLC, Chicago, Illinois Chicago ENT, Chicago, Illinois South Louisiana Ear, Nose, Throat & Facial Plastic Surgery - PPDS, Mandeville, Louisiana Chesapeake Clinical Research, Inc., White Marsh, Maryland Brigham and Women's Hospital, Boston, Massachusetts University of Missouri, Columbia, Missouri Washington University School of Medicine, St Louis, Missouri Circuit Clinical/Mercer Allergy and Pulmonary Associates, Hamilton, New Jersey Madison ENT & Facial Plastic Surgery, New York, New York New York Allergy and Sinus Center, New York, New York Equity Medical, The Bronx, New York Optimed Research, LTD, Columbus, Ohio Medical University of South Carolina- Department of Otolaryngology and Head and Neck Surgery, Charleston, South Carolina Alina Clinical Trials, Dallas, Texas UT Southwestern Medical Center, Dallas, Texas University of Texas Physicians Department of Otorhinolaryngology Clinc, Houston, Texas Ear Nose and Throat Associates of Texas PA, McKinney, Texas Alamo ENT Associates, San Antonio, Texas Eastern Virginia Medical School, Norfolk, Virginia Richmond Ear Nose and Throat, Richmond, Virginia The Medical College of Wisconsin, Milwaukee, Wisconsin Argentina
CEMLO - Centro de Especialidades Médicas Lobos, Beunos Aires Fundacion Respirar, Buenos Aires Centro Platense en Investigaciones Respiratorias - CEPIR, Buenos Aires Centro de Investigaciones Clínicas - IESR - Rosario, Rosario Investigaciones en Patologías Respiratorias SRL, San Miguel de Tucumán CIMER-Centro Integral de Medicina Respiratoria, San Miguel de Tucumán Centro Respiratorio Infantil, Santa Fe CARE - Centro de Alergia y Enfermedades Respiratorias, Villa Crespo Belgium
Cliniques Universitaires Saint-Luc Avenue Hippocrate 10, Woluwe-Saint-Lambert Bulgaria
Multiprofile Hospital For Active Treatment Dr Tota Venkova A, Gabrovo Medical Center Medconsult Pleven OOD, Pleven Diagnostic-Consultative Centre Ascendent EOOD, Sofia Military Medical Academy - Multiprofile Hospital for Active Treatment - Sofia,, Sofia University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna, Sofia Multiprofile Hospital for Active treatment Trakia EOOD, Zagora Canada
St. Joseph's Hospital, Ontario The Gordon and Leslie Diamond Health Care Centre, Vancouver St Paul's Sinus Centre, Vancouver China
Beijing Hospital, Beijing Beijing Tongren Hospital, Beijing The First Affiliated Hospital of Bengbu Medical College, Bengbu The Third Xiangya Hospital of Central South University, Changsha Sichuan Provincial People's Hospital, Chengdu The First People's Hospital of Foshan, Foshan The First Affiliated Hospital Of Fujian Medical University, Fuzhou Shenzhen Second People's Hospital, Guangdong Hainan General Hospital, Haikou Hangzhou First People's Hospital, Hangzhou Huai'an First People's Hospital, Huai'an The First Affiliated Hospital of Nanchang University, Nanchang The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning
Denmark
Aalborg Universitetshospital Medicinerhuset Lungemedicinsk Forskningsenhed, Aalborg Aarhus University Hospital, Dept. of Ear-Nose-Throat, Aarhus Bispebjerg Hospital Department of Respiratory Medicine, Copenhagen Sjællands Universitets Hospital, Køge Germany
Charite-Universitatsmedizin Berlin, Berlin HNO Zentrum am Kudamm, Berlin Praxis für HNO und Allergologie, Dresden Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden IKF Pneumologie, Frankfurt am Main Universitätsklinikum Jena, Jena Universitätsklinikum Schleswig-Holstein, Lübeck Hungary
Ujpesti Egeszsegugyi Szolgaltato, Budapest Komarom-Esztergom Varmegyei Szent Borbala Korhaz, Tatabánya Italy
AOU Careggi- University of Florence, Florence Ospedale San Raffaele, Milan AOU Federico II Via Pansini, Naples Azienda Ospedaliera Di Padova, Padova Azienda Ospedaliero Universitaria Pisana - Stabilimento Santa Chiara, Pisa Fondazione Policlinico A. Gemelli IRCCS, Rome ASST Brianza - Vimercate Hospital, Vimercate Japan
Toyota Memorial Hospital, Aichi Clinic Kashiwanoha, Chiba University of Yamanashi Hospital, Chūō University of Fukui Hospital, Fukui Saiseikai Fukuoka General Hospital, Fukuoak Matsuda Hospital, Fukuoka Kyushu University Hospital, Fukuoka Osaka Habikino Medical Center, Habikino-shi Kansai Medical University Hospital, Hirakata Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital, Hokkaido Hyogo Medical University Hospital, Hyōgo Takarazuka City Hospital, Hyōgo Ibaraki Prefectural Central Hospital, Ibaraki Kagoshima Kouseiren Hospital, Kagoshima Mexico
Avenida Independencia, Aguascalientes Calle Pascual Orozco #2125 col. Magisterial Universidad, Chihuahua City Calle Penitenciaria, Guadalajara Jalsico Miguel Hidalgo 2525, Consultorio 2 Urgencias, Nuevo León Humboldt 302 Col. Centro, Oaxaca City Poland
Niepubliczny Zakład Opieki Zdrowotnej E-Vita, Bialystok Centrum Medyczne Pratia Katowice, Katowice Centrum Medyczne Angelius Provita, Katowice B&R Clinical Sp. z o.o, Kielce Centrum Medyczne All-Med, Krakow Centrum Medyczne Promed ul. Olszańska 5G, Krakow Specjalistyczny Niepubliczny Zakład Opieki Zdrowotnej Alergologia Plus Ośrodek Diagnostyki, Poznan Centrum Medyczne Biotamed Morawska Barbara, Wieliczka EMC INSTYTUT MEDYCZNY S.A. Przychodnia, Wroclaw Centrum Medyczne Oporów, Wroclaw Portugal
Unidade Local de Saúde de Almada-Seixal, E.P.E., Almada ULS da Região de Aveiro, EPE - Hospital Infante D. Pedro, Aveiro Centro Clínico Académico - Braga (2CA-Braga) (Hospital de Braga), Braga Unidade Local de Saúde Loures-Odivelas, Loures ULS do Algarve, EPE - Hospital de Portimão, Seco Portimao Faro Hospital Pedro Hispano, Senhora da Hora Romania
Centrul Medical Unirea SRL, Brasov Centrul Medical De Diagnostic Si Tratament Ambulator Neomed S.R.L, Brasov Centrul Medical De Diagnostic Si Tratament Ambulator Neomed S.R.L, Brasov Delta Health Care S.R.L, Bucharest Delta Health Care S.R.L, Bucharest Cardiomed S.R.L, Cluj-Napoca Centrul de Excelenta in Rinologie S.R.L, Dolj South Korea
Inje University Haeundae Paik Hospital, Busan CHA Bundang Medical Center, Gyeonggi-do Pusan National University Hospital, Pusan Seoul National University Bundang Hospital, Seongnam-si Korea University Anam Hospital, Seoul SNUH - Seoul National University Hospital, Seoul The Catholic University of Korea, Seoul Korea University Guro Hospital, Seoul SMG-SNU Boramae Medical Center, Seoul Ajou University Hospital, Suwon Spain
Hospital Universitario Virgen de la Macarena Avenida Dr. Fedriani, Andalucia Centro Médico Teknon, Barcelona Hospital Universitario de Jerez, Cadiz Hospital Clínico Universitario de Santiago, Galícia Hospital Universitario Fundación Jiménez Díaz, Madrid Clinica Universidad de Navarra, Pamplona Taiwan
Taipei Medical University Shuang Ho Hospital, New Taipei City National Taiwan University Hospital, Taipei United Kingdom
Bristol Royal Infirmary University Hospitals, Bristol Charing Cross Hospital, Chelsea James Paget University Hospitals NHS Foundation Trust, Great Yarmouth Royal Berkshire NHS Foundation Trust, London Guys and St Thomas' NHS Foundation Trust, London Newcastle upon Tyne Hospitals NHSFT Freeman Hospital, Newcastle upon Tyne Stepping Hill Hospital, Stockport
Key details Sponsor
Eli Lilly and Company
Enrollment target
~510 participants
Primary completion
May 2027
Age range
12 Years and older
Last updated March 2026
Interested in joining? Ningbo Medical Center Lihuili Hospital, Ningbo
The first Affilliated Hospital Shandong First Medical University, Shandong Tongji Hospital of Tongji University, Shanghai Shengjing Hospital of China Medical University, Shenyang The First Hospital of Shanxi Medical University, Taiyuan Tianjin People's Hospital, Tianjin Tonghua Central Hospital, Tonghua The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou Avenue Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan Renmin Hospital of Wuhan University, Wuhan The Affiliated Hospital of Xuzhou Medical University, Xuzhou First People's Hospital of Yinchuan, Yinchuan Yokohama City Minato Red Cross Hospital, Kanagawa Odawara Municipal Hospital, Kanagawa Tokai University Hospital, Kanagawa Kimitsu Chuo Hospital, Kisarazu 1-8-1, Kishinoura, Kitakyushu 3-54-2, Kotohirahommachi, Kumamoto Kyosai Hospital, Minami-Alps Tohoku Medical and Pharmaceutical University Hospital, Miyagi Ritsuzankai Iida Hospital, Nagano Niigata University Medical & Dental Hospital, Niigata Japan Community Health care Organization Osaka Hospital, Osaka Kansai Electric Power Hospital, Osaka Toho University Sakura Medical Center, Sakura Toho University Ohashi Medical Center, Tokyo Nihon University Itabashi Hospital, Tokyo Mie University Hospital, Tsu JCHO Shimonoseki Medical center, Yamaguchi Yamaguchi University Hospital, Yamaguchi Yokohama Minami Kyosai Hospital, Yokohama