A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004) — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(213 sites) United States
CBCC Global Research, Inc. ( Site 0123), Bakersfield, California Beverly Hills Cancer Center ( Site 0116), Beverly Hills, California Stamford Hospital ( Site 0136), Stamford, Connecticut Mount Sinai Cancer Center ( Site 0137), Miami Beach, Florida Orchard Healthcare Research Inc. ( Site 0115), Skokie, Illinois Truman Medical Center ( Site 0126), Kansas City, Missouri Cox Medical Center North ( Site 0133), Springfield, Missouri St. Vincent Frontier Cancer Center-Research ( Site 0105), Billings, Montana Atlantic Health System Morristown Medical Center ( Site 0121), Morristown, New Jersey New York Oncology Hematology, P.C. ( Site 0132), Albany, New York University of Cincinnati Medical Center-University of Cincinnati Cancer Center ( Site 0103), Cincinnati, Ohio Kettering Health Main Campus-Kettering Health Cancer Center ( Site 0106), Kettering, Ohio Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0134), Lancaster, Pennsylvania Oncology Consultants P.A. ( Site 0113), Houston, Texas Circuit Clinical/SSM Health Dean Medical Group ( Site 0129), Madison, Wisconsin Argentina
AUSTRAL MEDICAL CENTER ( Site 0302), CABA, Buenos Aires Centro Oncologico Korben ( Site 0304), CABA, Buenos Aires Instituto de Investigaciones Clínicas Mar del Plata ( Site 0300), Mar del Plata, Buenos Aires Fundacion Estudios Clinicos ( Site 0306), Rosario, Santa Fe Province Sanatorio Parque ( Site 0301), Rosario, Santa Fe Province Australia
Chris O'Brien Lifehouse ( Site 3000), Camperdown, New South Wales Frankston Hospital ( Site 3002), Frankston, Victoria One Clinical Research ( Site 3001), Nedlands, Western Australia Austria
Medizinische Universität Graz-Klinische Abteilung für Pulmonologie ( Site 2401), Graz, Styria Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2400), Vienna Brazil
Hospital Mario Penna ( Site 0436), Belo Horizonte, Minas Gerais Hospital de Câncer de Recife ( Site 0447), Recife, Pernambuco Oncoclínica Oncologistas Associados ( Site 0441), Teresina, Piauí Liga Norte Riograndense Contra o Câncer ( Site 0439), Natal, Rio Grande do Norte Hospital de Caridade de Ijuí ( Site 0438), Ijuí, Rio Grande do Sul Hospital de Clínicas de Passo Fundo ( Site 0442), Passo Fundo, Rio Grande do Sul Irmandade da Santa Casa de Misericórdia de Porto Alegre-Centro Multidisciplinar de Pesquisa Clínica ( Site 0435), Porto Alegre, Rio Grande do Sul Fundação Pio XII - Hospital de Câncer de Barretos-Unidade de Pesquisa Clínica ( Site 0437), Barretos, São Paulo Instituto Nacional de Câncer - INCA ( Site 0446), Rio de Janeiro Americas ( Site 0431), Rio de Janeiro Bulgaria
MBAL Uni Hospital-Department of Medical Oncology ( Site 1000), Panagyurishte, Pazardzhik Multiprofile Hospital for Active Treatment SerdikaМЕD EOOD-Second Department of Medical Oncology ( Site 1002), Sofia, Sofia (stolitsa) MHAT - Heart and Brain ( Site 1006), Pleven Canada
CancerCare Manitoba ( Site 0210), Winnipeg, Manitoba QEII Health Sciences Centre - Victoria General Site-Dept. of Medical Oncology ( Site 0208), Halifax, Nova Scotia Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0205), Hamilton, Ontario Sunnybrook Research Institute ( Site 0206), Toronto, Ontario St. Marys Hospital Center ( Site 0204), Montreal, Quebec Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0207), Trois-Rivières, Quebec Chile
Clinica Universidad Catolica del Maule-Oncology ( Site 0500), Talca, Maule Region Orlandi Oncologia-Oncology ( Site 0503), Santiago, Region M. de Santiago FALP-UIDO ( Site 0501), Santiago, Region M. de Santiago Centro de Oncología de Precisión-Oncology ( Site 0502), Santiago, Region M. de Santiago Bradfordhill-Clinical Area ( Site 0504), Santiago, Region M. de Santiago China
Anhui Provincial Cancer Hospital ( Site 3136), Hefei, Anhui Beijing Cancer hospital ( Site 3133), Beijing, Beijing Municipality Beijing Cancer hospital ( Site 3134), Beijing, Beijing Municipality Beijing Peking Union Medical College Hospital-pneumology department ( Site 3102), Beijing, Beijing Municipality Beijing Chest Hospital,Capital Medical University ( Site 3104), Beijing, Beijing Municipality Chongqing University Cancer Hospital ( Site 3119), Chongqing, Chongqing Municipality Army Medical Center of People's Liberation Army ( Site 3142), Chongqing, Chongqing Municipality Fujian Cancer Hospital ( Site 3127), Fuzhou, Fujian The First Affiliated hospital of Xiamen University ( Site 3148), Xiamen, Fujian The First Affiliated Hospital of Guangzhou Medical University ( Site 3108), Guangzhou, Guangdong Southern Medical University Nanfang Hospital ( Site 3128), Guangzhou, Guangdong Sun Yat-sen University Cancer Center ( Site 3137), Guangzhou, Guangdong France
Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 1103), Dijon, Bourgogne-Franche-Comté Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire ( Site 1106), Nîmes, Gard Clinique Teissier Groupe ( Site 1100), Valenciennes, Nord Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 1101), Clermont-Ferrand, Puy-de-Dome Centre Hospitalier d'Avignon-Service d'Oncologie médicale et d'hématologie clinique ( Site 1104), Avignon, Vaucluse Hôpital Ambroise Paré-Department of Respiratory Diseases and Thoracic Oncology ( Site 1105), Boulogne-Billancourt, Île-de-France Region Georgia
High Technology Hospital Medcenter ( Site 1203), Batumi, Adjara Caucasus Medical Centre ( Site 1202), Tbilisi, Adjara American Hospital Network LLC ( Site 1208), Tbilisi Todua Clinic, LLC ( Site 1204), Tbilisi TSMU and Ingorokva High Medical Technology University Clinic LTD ( Site 1201), Tbilisi New Hospitals ( Site 1200), Tbilisi Cancer Research Centre. Mardaleishvili Medical Centre ( Site 1205), Tbilisi Tbilisi Institute of Medicine ( Site 1206), Tbilisi Germany
Marienhospital Stuttgart ( Site 1302), Stuttgart, Baden-Wurttemberg Evangelisches Krankenhaus Bielefeld - Johannesstift ( Site 1307), Bielefeld, North Rhine-Westphalia Krankenhaus Bethanien ( Site 1303), Solingen, North Rhine-Westphalia Greece
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 1402), Pátrai, Achaia THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1400), Athens, Attica Athens Medical Center ( Site 1406), Marousi, Attica University General Hospital of Larissa-Oncology Clinic ( Site 1403), Larissa, Thessaly Agios Loukas Clinic ( Site 1404), Thessaloniki G. Papanikolaou General Hospital-Pulmonary Clinic of Aristotle University of Thessaloniki ( Site 1405), Thessaloniki India
Sir H. N. Reliance Foundation Hospital and Research Centre ( Site 3201), Mumbai, Maharashtra Indraprastha Apollo Hospitals-APOLLO RESEARCH INNOVATION ( Site 3203), New Delhi, National Capital Territory of Delhi Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia clinica sperimentale Toraco-Polmonare ( Site 1607), Naples, Campania Ospedale Santa Maria delle Croci ( Site 1606), Ravenna, Emilia-Romagna CRO-IRCCS-Clinical Oncology ( Site 1605), Aviano, Friuli Venezia Giulia Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1601), Rome, Lazio Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1600), Milan, Lombardy Istituto Europeo di Oncologia IRCCS-Divisione di Oncologia Toracica ( Site 1604), Milan, Lombardy A.O.R.N. Ospedale dei Colli - Monaldi V.-U.O.C Pneumologia Oncologica DH PNL ONC ( Site 1602), Naples, Napoli Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1609), Rome, Roma Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno-UOC Oncologia Medica Livorno ( Site 1608), Livorno, Tuscany IOV - Istituto Oncologico Veneto IRCCS UOSD - Unità di ricerca clinica ( Site 1603), Padova Japan
Nagoya University Hospital ( Site 3309), Nagoya, Aichi-ken Fujita Health University Hospital ( Site 3310), Toyoake, Aichi-ken National Cancer Center Hospital East ( Site 3303), Kashiwa, Chiba National Hospital Organization Shikoku Cancer Center ( Site 3315), Matsuyam, Ehime National Hospital Organization Kyushu Cancer Center ( Site 3316), Fukuoka, Fukuoka Kurume University Hospital ( Site 3317), Kurume, Fukuoka Gunma Prefectural Cancer Center ( Site 3302), Ōta, Gunma Sapporo Medical University Hospital ( Site 3324), Sapporo, Hokkaido Kanazawa University Hospital ( Site 3308), Kanazawa, Ishikawa-ken St. Marianna University Hospital ( Site 3320), Kawasaki, Kanagawa Saiseikai Matsusaka Municipal Hospital ( Site 3311), Matsusaka, Mie-ken Miyagi Cancer Center ( Site 3301), Natori-shi, Miyagi Mexico
Arké SMO S.A. de C.V. ( Site 0602), Mexico City, Mexico City Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Hematologia and Oncologia ( Site 0600), Monterrey, Nuevo León Oaxaca Site Management Organization S.C. ( Site 0603), Oaxaca City Netherlands
Ziekenhuis Gelderse Vallei ( Site 1705), Ede, Gelderland Ziekenhuis St. Jansdal-Poli Longziekten ( Site 1701), Harderwijk, Gelderland Isala, locatie Zwolle-Poli Longziekten ( Site 1700), Zwolle, Overijssel Universitair Medisch Centrum Utrecht ( Site 1704), Utrecht New Zealand
Auckland City Hospital ( Site 3400), Auckland Philippines
The Medical City ( Site 3507), Pasig, National Capital Region Lung Center of the Philippines-Pulmonary, Critical Care and Sleep Medicine ( Site 3503), Quezon City, National Capital Region Veterans Memorial Medical Center-Section of Oncology ( Site 3505), Quezon City, National Capital Region ST. LUKE'S MEDICAL CENTER-Medical oncology ( Site 3501), Quezon City, National Capital Region Poland
Szpital Specjalistyczny im. Henryka Klimontowicza ( Site 1801), Gorlice, Lesser Poland Voivodeship Pratia MCM Krakow ( Site 1808), Krakow, Lesser Poland Voivodeship Uniwersytecki Szpital Kliniczny nr 4 w Lublinie ( Site 1805), Lublin, Lublin Voivodeship Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1800), Warsaw, Masovian Voivodeship Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1804), Przemyśl, Podkarpackie Voivodeship Romania
Centrul de Diagnostic si Tratament Provita. ( Site 1992), Bucharest, Bucharest Centrul de Oncologie Sfantul Nectarie-Medical ( Site 1994), Craiova, Dolj Cabinet Medical Oncomed ( Site 1998), Timișoara, Timiș County SC ONCO CARD SRL ( Site 1995), Brasov Institutul Oncologic Cluj-Oncologie Medicala ( Site 1999), Cluj-Napoca Sigmedical Services SRL ( Site 1997), Suceava South Korea
The Catholic University of Korea, Incheon St. Mary's Hospital ( Site 3606), Bupyeong-gu, Incheon Chonnam National University Hwasun Hospital-Pulmonology ( Site 3604), Hwasun, Jeonranamdo The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 3600), Suwon, Kyonggi-do Pusan National University Yangsan Hospital-Lung Cancer Clinic ( Site 3603), Yangsan, Kyongsangnam-do Chungnam national university hospital ( Site 3602), Junggu, Taejon-Kwangyokshi Kyung Hee University Hospital ( Site 3605), Seoul Korea University Guro Hospital ( Site 3601), Seoul Spain
Hospital Universitario Virgen de la Victoria ( Site 2021), Málaga, Andalusia Hospital Insular de Gran Canaria-Oncology ( Site 2019), Las Palmas de Gran Canaria, Las Palmas HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON-ONCOLOGY ( Site 2012), Madrid, Madrid, Comunidad de H.R.U Málaga - Hospital General-Oncology ( Site 2014), Málaga, Malaga Hospital Universitari Vall d Hebron ( Site 2010), Barcelona Hospital Universitario La Princesa ( Site 2020), Madrid Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 2017), Madrid Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2015), Seville Turkey (Türkiye)
Ege Universitesi Hastanesi-Chest Diseases Department ( Site 2102), Bornova, İzmir Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 2107), Adana SBU GULHANE EGITIM VE ARASTIRMA HASTANESI Onkoloji ( Site 2104), Ankara Hacettepe Universite Hastaneleri-oncology hospital ( Site 2101), Ankara Memorial Ankara Hastanesi-Medical Oncology ( Site 2106), Ankara Ankara Bilkent Şehir Hastanesi ( Site 2100), Ankara Medipol Mega Universite Hastanesi-oncology ( Site 2105), Istanbul TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2103), Istanbul Ukraine
COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 2209), Cherkasy, Cherkasy Oblast Regional Municipal Non-profit Enterprise "Bukovinian Clinica-structural unit of the clinical trials ( Site 2210), Chernivtsi, Chernivetska Oblast Medical Center "Mriya Med-Service"-Clinical Research Department ( Site 2215), Kryvyi Rih, Dnipropetrovsk Oblast Communal Non-Commercial Enterprise "Prykarpatski Clinical On-Surgery department #2 ( Site 2202), Ivano-Frankivsk, Ivano-Frankivsk Oblast Kirovohrad Regional Oncology Center-Chemotherapy department ( Site 2204), Kropyvnytskyi, Kirovohrad Oblast Medical Center "MedOffice Group" ( Site 2219), Kiev, Kyivska Oblast Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 2217), Lviv, Lviv Oblast Rivne Regional Clinical Hospital ( Site 2205), Rivne, Rivne Oblast ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2920), Rivne, Rivne Oblast Communal Noncommercial Enterprise "Podillia Regional Oncolog-Cardiothoracic department ( Site 2211), Vinnytsia, Vinnytsia Oblast ME Volyn Regional Clinical Hospital of the Volyn Regional Council ( Site 2216), Lutsk, Volyn Oblast United Kingdom
Milton Keynes Hospital ( Site 2304), Milton Keynes, Buckinghamshire Royal Devon & Exeter Hospital-Oncology ( Site 2302), Exeter, Devon
Key details Sponsor
Merck Sharp & Dohme LLC
Enrollment target
~600 participants
Primary completion
February 2029
Age range
18 Years and older
Last updated April 2026
Interested in joining? Harbin Medical University Cancer Hospital ( Site 3123), Harbin, Heilongjiang JIAMUSI TUBERCULOSIS HOSPITAL(CANCER HOSPITAL) ( Site 3124), Jiamusi, Heilongjiang Henan Cancer Hospital ( Site 3149), Zhengzhou, Henan Tongji Hospital Tongji Medical,Science & Technology ( Site 3113), Wuhan, Hubei Hubei Cancer Hospital ( Site 3126), Wuhan, Hubei The Second Xiangya Hospital of Central South University ( Site 3130), Changsha, Hunan Hunan Cancer Hospital ( Site 3141), Changsha, Hunan Nanjing Gulou Hospital ( Site 3122), Nanjing, Jiangsu Nanjing First Hospital ( Site 3154), Nanjing, Jiangsu The First Affiliated Hospital of Soochow University ( Site 3146), Suzhou, Jiangsu Affiliated Hospital of Jiangnan University(Wuxi Fourth People's Hospital ) ( Site 3155), Wuxi, Jiangsu The Second Affiliated Hospital of Nanchang University ( Site 3139), Nanchang, Jiangxi The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 3138), Nanchang, Jiangxi Jilin Province Tumor Hospital ( Site 3107), Changchun, Jilin The First Affiliated Hospital of Xi'an Jiaotong University ( Site 3150), Xi'an, Shaanxi Shandong Cancer Hospital ( Site 3116), Jinan, Shandong LinYi Cancer Hospital ( Site 3111), Linyi, Shandong Shanghai Chest Hospital ( Site 3100), Shanghai, Shanghai Municipality Fudan University Shanghai Cancer Center ( Site 3144), Shanghai, Shanghai Municipality Zhongshan Hospital,Fudan University ( Site 3143), Shanghai, Shanghai Municipality Shanxi Cancer Hospital ( Site 3131), Taiyuan, Shanxi The Second Affiliated Hospital of Air Force Medical University ( Site 3117), Xian, Shanxi The Second Affiliated Hospital of Air Force Medical University ( Site 3152), Xian, Shanxi West China Hospital, Sichuan University ( Site 3140), Chengdu, Sichuan The Third People's Hospital of Chengdu (CDTPH) ( Site 3157), Chengdu, Sichuan Sichuan Cancer hospital. ( Site 3109), Chengdu, Sichuan The Second People's Hospital of Neijiang ( Site 3105), Neijiang, Sichuan Xinjiang Medical University Cancer Hospital - Urumqi ( Site 3101), Ürümqi, Xinjiang Yunnan Province Cancer Hospital ( Site 3153), Kunming, Yunnan The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 3115), Hangzhou, Zhejiang Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 3121), Hangzhou, Zhejiang Taizhou Hospital of Zhejiang Province ( Site 3145), Linhai, Zhejiang The First Affiliated Hospital of Wenzhou Medical University ( Site 3151), Wenzhou, Zhejiang Sendai Kousei Hospital ( Site 3300), Sendai, Miyagi
Kansai Medical University Hospital ( Site 3312), Hirakata, Osaka Osaka Medical and Pharmaceutical University Hospital ( Site 3313), Takatsuki, Osaka Saitama Prefectural Cancer Center ( Site 3304), Kitaadachi-gun, Saitama Nippon Medical School Hospital ( Site 3306), Bunkyo, Tokyo Toho University Omori Medical Center ( Site 3319), Ōta-ku, Tokyo Tokyo Medical University Hospital ( Site 3307), Shinjuku, Tokyo National Center for Global Health and Medicine ( Site 3305), Shinjuku, Tokyo Chiba University Hospital ( Site 3322), Chiba Hiroshima City Hiroshima Citizens Hospital ( Site 3314), Hiroshima Saiseikai Kumamoto Hospital ( Site 3318), Kumamoto Niigata University Medical & Dental Hospital ( Site 3323), Niigata Osaka Metropolitan University Hospital ( Site 3321), Osaka