A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2) — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(283 sites) United States
Patty & George Hoag Cancer Center, Newport Beach, California UC San Diego Health - Moores Cancer Center, San Diego, California UCSF Bakar Precision Cancer Medicine Building - Thoracic Surgery and Oncology, San Francisco, California UCLA Health Santa Monica Cancer Care, Santa Monica, California The Oncology Institute of Hope and Innovation - Fort Lauderdale 17th Street, Fort Lauderdale, Florida Memorial Cancer Institute at Miramar, Miramar, Florida AdventHealth Cancer Institute Orlando, Orlando, Florida Moffitt Cancer Center - Magnolia Campus, Tampa, Florida Moffitt Cancer Center, Tampa, Florida Piedmont Healthcare - Atlanta, Atlanta, Georgia John B. Amos Cancer Center, Columbus, Georgia University of Illinois Hospital - Outpatient Cancer Care Center, Chicago, Illinois The University of Chicago Medical Center - Hyde Park - Hematology & Oncology, Chicago, Illinois UM Greenebaum Comprehensive Cancer Center, Baltimore, Maryland UMass Memorial Medical Center - University Campus - Hematology/Oncology, Worcester, Massachusetts Profound Research -OMG - TriAtria Cancer Center, Farmington Hills, Michigan Profound Research - OMG - Royal Oak Cancer Center, Royal Oak, Michigan M Health Fairview Masonic Cancer Clinic - Clinics and Surgery Center, Minneapolis, Minnesota R.J. Zuckerberg Cancer Center, New Hyde Park, New York UC Medical Center - Oncology, Cincinnati, Ohio Providence Cancer Institute - Franz Clinic, Portland, Oregon Providence Oncology and Hematology Care Clinic Westside, Portland, Oregon Allegheny General Hospital, Pittsburgh, Pennsylvania University Hospital Simmons Cancer Center Lung/Head Neck Clinic, Dallas, Texas The University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston, Texas VCU Health Ambulatory Care Center - Cardiology, Richmond, Virginia Argentina
Fundación Cenit para la Investigación en Neurociencias, CABA, Ciudad Auton. de Buenos Aires Hospital Italiano de Buenos Aires, Buenos Aires Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC), Buenos Aires Centro Médico Privado CEMAIC, Córdoba Instituto Argentino de Diagnostico y Tratamiento (IADT), TBC Centro de Investigaciones Clínicas, Clínica Viedma, Viedma Australia
NSW Health - Blacktown Hospital, Blacktown, New South Wales Concord Repatriation General Hospital - Medical Oncology Clinical Trials Unit, Concord, New South Wales Calvary Mater Hospital Newcastle - Oncology, Waratah, New South Wales University of the Sunshine Coast, Buderim, Queensland Toowoomba Hospital Oncology Clinical Trials, Toowoomba, Queensland Austin Hospital - Olivia Newton John Cancer Research Institute, Heidelberg, Victoria The Canberra Hospital (TCH) - Canberra Region Cancer Centre (CRCC), Garran Austria
Uniklinikum Salzburg, Universitätsklinik für Innere Medizin III, Vienna, State of Salzburg Uniklinikum Salzburg, Universitätsklinik für Pneumologie/ Lungenheilkunde, Vienna, State of Salzburg Medizinische Universität Wien Universitätsklinik f. Innere Medizin I Klinische Abteilung für Onkologie, Vienna, State of Vienna Klinik Floridsdorf, Pneumo-onkologische Ambulanz und Tagesklinik, Vienna Belgium
UZ Leuven Gasthuisberg - Pneumology Department, Leuven, Vlaams-Brabant AZ Delta | Clinical Trial Center - Pneumology, Roeselare, West-Flanders Antwerp University Hospital | Oncology Department, Antwerp Brazil
Pronutrir Fortaleza - CE, Fortaleza, Ceará Centro Paulista de Oncologia (CPO) - Sao Paulo - Faria Lima, Brasília, Federal District Rede DoR Recife - PE, Recife, Pernambuco Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica, Natal, Rio Grande do Norte Centro de Pesquisa da Clínica de Oncologia Reichow, Blumenau, Santa Catarina NAIC - Instituto do Cancer, Bauru, São Paulo Fundacao Pio XII - Hospital de Cancer de Barretos, Jaú, São Paulo Hospital de Base | Funfarme - Centro Integrado de Pesquisa - Cardiologia, São José do Rio Preto, São Paulo Hospital Sirio Libanes, São Paulo, São Paulo A Beneficencia Portuguesa de Sao Paulo - Hospital BP Mirante, São Paulo, São Paulo Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia, São Paulo, São Paulo Irmandade Santa Casa de Misericordia de Porto Alegre | Oncology, São Paulo, São Paulo Bulgaria
MHAT Uni Hospital, Panagyurishte, Pazardzhik Province MHAT "Heart and brain" Pleven, Pleven, Pleven Province Complex Oncology Center - Plovdiv EOOD, Plovdiv, Plovdiv Province MHAT Park Hospital EOOD, Plovdiv, Plovdiv Province Multiprofile Hospital for Active Treatment "Sveta Sofia", Sofia, Sofia City Province MHAT Serdika, Sofia, Sofia City Province Specialized Hospital for Active Treatment of Oncology, Sofia, Sofia City Province University Multiprofile Hospital For Active Treatment Sofiamed OOD, Sofia, Sofia, Sofia City Province MHAT Sveta Marina EAD, Varna, Varna Province Canada
BC Cancer | Vancouver, Vancouver, British Columbia Brampton Civic Hospital | Oncology, Brampton, Ontario Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology, Toronto, Ontario Jewish General Hospital - Department of Pulmonary Oncology, Montreal, Quebec China
Beijing Cancer Hospital - Oncology Department, Beijing, Beijing Municipality Beijing Hospital, Beijing, Beijing Municipality Fujian Cancer Hospital, Fuzhou, Fujian Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Union Hospi, Tongji Med College, Huazhong Univ. Scien&Tech, Wuhan, Hubei Hubei Cancer Hospital, Wuhan, Hubei Hunan Cancer Hospital - Oncology Department, Changsha, Hunan NJ Drum Tower Hospital, the Affil Hos of NJ Univ Med School, Nanjing, Jiangsu Jilin Cancer Hospital, Changchun, Jilin Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, Shanghai Municipality West China Hospital Sichuan University, Chengdu, Sichuan Sir Run Run Shaw Hospital, Zhejiang Univ. School of Medicine - Oncology Department, Hangzhou, Zhejiang Czechia
Krajská nemocnice T. Bati - Pneumoonkologická a klinická onkologie, Zlín, Zlín Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP), Brno Nemocnice AGEL Nový Jicín a.s. - Oddelení radioterapie a onkologie, Nový Jicín Fakultní Nemocnice Olomouc - Klinika plicních nemocí a tuberkulózy, Olomouc Nemocnice AGEL Ostrava-Vítkovice a. s. - Plicní oddelení, Ostrava - Vítkovice Denmark
Rigshospitalet - Kræftbehandling, Copenhagen, Capital Region Aarhus Universitetshospital, Aarhus N, Central Jutland Regionshospitalet Gødstrup - Medicinsk afdeling, Herning, Central Jutland Aalborg University hospital - oncology department, Aalborg, North Denmark Odense University Hospital - Oncology Department, Odense, Region Syddanmark Finland
Turku University Hospital, Turun yliopistollinen sairaala (TYKS) - Keuhkosairauksien poliklinikka, Turku, Southwest Finland Docrates Mehiläinen Syöpäsairaala, Helsinki, Uusimaa France
Centre Hospitalier Michallon Grenoble - Service pneumologie, La Tronche, Auvergne-Rhône-Alpes hopital Lyon sud HCL - Pneumologie aigue specialisee et cancerologie thoracique, Pierre-Bénite, Auvergne-Rhône-Alpes Hopital La Cavale Blanche - CHU de Brest - institut de cancerologie et d'imagerie, Brest, Brittany Region hopital Emile Muller - Service Pneumologie, Mulhouse, Grand Est Institut Coeur Poumon CHRU Lille - Pole Cardio-vasculaire et pulmonaire, Lille, Hauts-de-France Institut Bergonie - Unicancer Nouvelle Aquitaine, Bordeaux, New Aquitaine Centre Hospitalier Universitaire de Limoges - unite oncologie thoracique, Limoges, New Aquitaine CHU de Rouen - Hopital Charles Nicolle - Service de Pneumologie, Rouen, Normandy CHU Montpellier - Hopital Arnaud de Villeneuve - Service oncologie thoracique, Montpellier, Occitanie Hopital Nord Laennec - Oncologie medicale thoracique et digestive, Nantes, Pays de la Loire Region Institut de Cancerologie Ouest - Saint-Herblain, Saint-Herblain, Pays de la Loire Region
Germany
Universitaetsklinikum Giessen und Marburg - Medizinische Klinik IV Organonkologie, Giessen, Hesse Kliniken der Stadt Köln gGmbH - Krankenhaus Merheim - Lungenklinik, Cologne, North Rhine-Westphalia Universitaetsklinikum Essen - Innere Klinik (Tumorforschung), Essen, North Rhine-Westphalia Charité Universitätsmedizin Berlin CBF - Med. Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie, Berlin Universitätsklinikum Frankfurt - Medizinische Klinik II, Hämatologie und Onkologie, Frankfurt Lungenklinik Hemer, Thorakale Onkologie und onkologische Palliativmedizin, Hemer Klinikum Nürnberg - Klinik für Innere Medizin 3, Schwerpunkt Pneumologie (Lungenheilkunde), Nuremberg Robert Bosch Krankenhaus - Haematologie, Onkologie und Palliativmedizin, Stuttgart Greece
University General Hospital Attikon-4th Department of Internal Medicine, Chaïdári, Attica Genesis Hospital- Department of Pathological Oncology, Pylaia Thessaloniki, Thessaloniki ?enry Dunant Hospital Center-4th Oncology Department and Clinical Trials Unit, Athens Thoracic General Hospital Of Athens I Sotiria-3rd University Department of Internal Medicine, Athens General Hospital of Athens "Alexandra''-Plasma Cell Dyscrasias,Department of Clinical Therapeutics,School of Medicine,NKUA, Athens University General Hospital Attikon, 2nd Department of Propaedeutic and Internal Medicine, Athens General University Hospital Of Larissa-Department of Medical Oncology, Larissa Metropolitan Hospital- 4th Oncology Clinic, Piraeus Geniko Nosokomeio Thessalonikis George Papanikolaou-Pulmonary Department, Thessaloniki Hong Kong
Prince of Wales Hospital, Hong Kong, Hong Kong SAR Queen Elizabeth Hospital Hong Kong, Hong Kong, Hong Kong SAR Queen Mary Hospital, Hong Kong, Hong Kong SAR Hong Kong United Oncology Centre, Kowloon Hungary
Budapesti Uzsoki Utcai Korhaz - Tüdogyógyászati Osztály, Budapest Komarom-Esztergom Varmegyei Szent Borbala Korhaz, Tatabánya Israel
Assuta Ashdod Public Hospital (R.A), Ashdod Soroka Medical Center- Legacy Heritage Cancer Center, Beersheba Shaare Zedek Medical Center (SZMC), Jerusalem Tel-Aviv Sourasky Medical Center, Tel Aviv Italy
AORN San Giuseppe Moscati Avellino - U.O.C. Oncologia Medica, Avellino, Campania Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - UOC Oncologia Medica, Bologna, Emilia-Romagna Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l. - GDP Toracica, Meldola, Emilia-Romagna Centro di Riferimento Oncologico di Aviano - Oncologia Medica e dei Tumori Immuno-Correlati, Aviano, Friuli Venezia Giulia I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena -- Oncologia Medica 2, Rome, Lazio Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOSD Oncologia Toraco-Polmonare, Rome, Lazio Fondazione IRCCS Istituto Nazionale dei Tumori - S. C. Oncologia Medica 1, Milan, Lombardy Istituto Europeo di Oncologia s.r.l - Oncologia Toracica, Milan, Lombardy Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia, Rozzano, Lombardy Azienda Ospedaliero-Universitaria San Luigi Gonzaga - Oncologia Medica, Orbassano, Piedmont Istituto Oncologico Veneto_Padova - UOC Oncologia 2, Padova, Veneto
Japan
National Hospital Organization Nagoya Medical Center, Nagoya, Aichi-ken National Cancer Center Hospital East, Kashiwa, Chiba Hokkaido University Hospital, Sapporo, Hokkaido National Hospital Organization Himeji Medical Center, Himeji, Hyōgo Kobe University Hospital, Kobe, Hyōgo Kitasato University Hospital, Sagamihara, Kanagawa Sendai Kousei Hospital, Sendai, Miyagi Kansai Medical University Hospital, Hirakata, Osaka Kindai University Hospital, Sakai, Osaka Saitama Cancer Center, Kitaadachi-gun, Saitama Nippon Medical School - Nippon Medical School Hospital - Cancer Center, Bunkyo-ku, Tokyo Tottori University Hospital, Yonago, Tottori National Hospital Organization-Yamaguchi-Ube Medical Center (Sanyo Hospital), Ube, Yamaguchi Malaysia
Universiti Malaya Medical Centre, Kuala Lumpur, Kuala Lumpur University Hospital Kebangsaan Malaysia, Cheras, Kuala Lumpur and Selangor Gleneagles Penang Medical Center, George Town, Pulau Pinang Sunway Medical Centre Penang, Perai, Pulau Pinang Beacon Hospital, Petaling Jaya, Selangor Columbia Asia Hospital Bukit Rimau, Shah Alam, Selangor Sunway Medical Centre, Subang Jaya, Selangor Mexico
Instituto Nacional de Cancerología, Mexico City, Mexico City Oncare Viaducto Nápoles, Mexico City Hospital Universitrio Dr. José Eleuterio González. Servicio de Oncologia, Monterrey Oncología Integral Satélite, Naucalpan Clinica Integral Internacional de Oncologia S. de R.L. de C.V., Puebla City ONCARE Treatment Center, San Pedro Garza García Netherlands
Radboud University Medical Center | Afdeling Interne Geneeskunde, Nijmegen, Gelderland Nederlands Kanker Instituut, Amsterdam, North Holland Poland
Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej, Warsaw, Masovian Voivodeship Narodowy Instytut Onkologii-im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy - Nowotworow Pluca i Klatki Piersiowej, Warsaw, Masovian Voivodeship Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok Swietokrzyskie Centrum Onkologii, Kielce Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi, Lodz Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy w Otwocku, Otwock Wielkopolskie Centrum Pulmonologii i Torakochirurgii, Poznan Instytut Gruzlicy i Chorob Pluc, Warsaw Dolnoslaskie Centrum Onkologii, Pulmonologii i Hematologii, Wroclaw Portugal
Hospital Pedro Hispano | Clinical Research Center, Matosinhos Municipality, Porto District Unidade Local de Saúde de Coimbra, E.P.E. - Hospitais da Universidade de Coimbra - Serviço de Urologia, Coimbra Fundacao Champalimaud | Centro Clinico Champalimaud - Unidade Investigacao Clinica, Lisbon CHULN - Hospital Pulido Valente, Lisbon Romania
Radiotherapy Center Cluj SRL, Flore?ti, Comuna Floresti Sc Oncolab Srl, Craiova, Dolj Institutul Oncologic Prof. Dr. Alexandru Trestioreanu (IOB); Oncologie Medicala II, Bucharest Spitalul Clinic Coltea, Bucharest CardioMed S.R.L., Cluj-Napoca Institutul Oncologic Prof. Dr. Ion Chiricuta, Cluj-Napoca Centrul de Oncologie Sfantul Nectarie, Craiova S.C Ovidius Clinical Hospital SRL - Oncology Department, Ovidiu Singapore
National Cancer Center Singapore - Oncology Department, Singapore Raffles Cancer Centre, Singapore OncoCare Cancer Centre | Gleneagles Medical Centre, Singapore Tan Tock Seng Hospital, Singapore Curie Oncology | Farrer, Singapore Slovakia
POKO Poprad s.r.o., Poprad Fakultna nemocnica Trnava, Trnava South Korea
Gyeongsang National University Hospital, Jinju, Gyeongsangnam-do Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do Chonnam National University Hwasun Hospital | Pulmonology and Critical Care Medicine, Hwasun Gun, Jeollanam-do Chungbuk National University Hospital, Cheongju-si, North Chungcheong Severance Hospital, Yonsei University Health System - Oncology Department, Seoul, Seoul Teugbyeolsi Seoul National University Hospital, Seoul, Seoul Teugbyeolsi Samsung Medical Center - Oncology Department, Seoul St.Vincent's Hospital - Oncology Department, Suwon Spain
Hospital Germans Trias I Pujol | Oncologia, Badalona, Barcelona Hospital Universitario Puerta De Hierro De Majadahonda | Oncologia, Majadahonda, Madrid Hospital Universitario De Navarra | Oncologia, Pamplona, Navarre Complexo Hospitalario Universitario A Coruna | Oncologia, A Coruña Hospital Universitari Dexeus Grupo Quironsalud | Oncologia, Barcelona Hospital Universitari Vall D Hebron | Oncologia, Barcelona Hospital Clinic De Barcelona | Oncologia, Barcelona Hospital General Universitario Gregorio Maranon | Oncologia, Madrid Hospital Universitario Ramon Y Cajal | Oncologia, Madrid Hospital Universitario Fundacion Jimenez Diaz | Oncologia, Madrid Fundacion Instituto Valenciano De Oncologia | Oncologia, Valencia Hospital Universitario Y Politecnico La Fe | Oncologia, Valencia Sweden
Skåne University Hospital, Lund, Skåne County Norrland University Hospital - Cancercentrum, Umeå, Västerbotten County Switzerland
Kantonsspital Baden, Baden, Canton of Aargau HFR Freiburg - Kantonsspital, Fribourg Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City Chung Shan Medical University Hospital, Taichung Taichung Veterans General Hospital, Taichung National Cheng Kung University Hospital, Tainan Chi-Mei Medical Center, Liouyine, Tainan National Taiwan University Hospital (NTUH) - Cancer Research Center, Taipei National Taiwan University Hospital, Taipei Taipei Veterans General Hospital, Taipei Turkey (Türkiye)
Adana Sehir Egitim ve Arastirma Hastanesi, Yüreğir, Adana Ankara Bilkent Sehir Hastanesi, Bilkent Ankara, Ankara Ankara Etlik Sehir Hastanesi, Yenimahalle, Ankara Istanbul Medeniyet Üniversitesi Göztepe Süleyman Yalçin Sehir Hastanesi, Kadıköy, Istanbul I.A.Ü. VM Medical Park Florya Hastanesi, Küçükçekmece, Istanbul Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi, Istanbul Ege Universitesi Tip Fakultesi Hastanesi, Izmir Sakarya Universitesi Egitim ve Arastirma Hastanesi, Sakarya Ukraine
LLC "RDP Ukraine" - Medical Department, Dnipro Private Enterprise Private Production Company "Acinus", Treatment and Diagnostic Center, Kropyvnytskyi Kyiv City Clinical Oncology Center - Department of Chemotherapy #1, Kyiv Limited Liability Company "MedOffice Group Medical Center", Kyiv Medical Center LLC "Verum Expert Clinic", Kyiv Regional Medical Oncology Centre_Oncology Chemotherapy Department, Lutsk Municipal Enterprise Rivne Regional Antitumor Center of the Rivne Regional Council, Abdominal department, Rivne MNCE "Uzhhorod City Multidisciplinary Clinical Hospital" -Oncology Department, Uzhhorod United Kingdom
Torbay Hospital, Torquay, Devon Belfast City Hospital, Belfast, Northern Ireland Royal Surrey County Hospital, Guildford, Surrey Velindre University NHS Trust | Velindre Cancer Centre - Clinical Trials Unit, Cardiff, Wales
Key details Enrollment target
~444 participants
Primary completion
October 2027
Age range
18 Years and older
Last updated April 2026
Interested in joining? Zhejiang Cancer Hospital, Hangzhou, Zhejiang
Zhejiang University School of Medicine - Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang Cancer Hospital, Chinese Academy of Medical Sciences, Beijing The People's Liberation Army General Hospital (Beijing 301 Hospital), Beijing Beijing chest hospital, Capital Medical University, Beijing University of Electronic Science & Technology of China - Sichuan Cancer Hospital & Institute (Sichuan Provincial Tumor Hospital), Chengdu The first Affiliated Hospital of Guangzhou Medical University, Guangzhou Shandong University - Shandong Cancer Hospital, Jinan LinYi Cancer Hospital (Linyi Tumor Hospital), Linyi Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University, Nanjing Guangxi Medical University (GXMU) - Affiliated Tumor Hospital, Nanning Zhongshan Hospital, Fudan University, Shanghai Xiamen University - The First Affiliated Hospital, Xiamen Centre Antoine Lacassagne - Departement Oncologie, Nice, Provence-Alpes-Côte d'Azur Region
Centre Hospitalier Intercommunal Creteil - Service de pneumologie, Créteil, Île-de-France Region hopital cochin APHP - service de pneumologie, Paris, Île-de-France Region Institut Curie - Paris - Oncologie medicale, Paris, Île-de-France Region Hopital Foch - Oncologie digestive et thoracique, Suresnes, Île-de-France Region Gustave Roussy - Departement Oncologie-Radiotherapie, Villejuif, Île-de-France Region Careggi University Hospital - Oncologia Clinica, Florence
Careggi University Hospital - Oncologia Clinica, Florence Ospedale Vito Fazzi Lecce - Oncologia, Lecce Ospedale San Raffaele s.r.l. - Oncologia Medica, Milan Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello - Oncologia Medica, Palermo ASST Sette Laghi_Ospedale Macchi - Oncologia, Varese Centro Ricerche Cliniche Di Verona S.r.l. - Oncologia, Verona National Hospital Organization Kyushu Medical Center, Fukuoka Niigata Cancer Center Hospital, Niigata Osaka International Cancer Institute, Osaka