Plain-English translation of NCT06458712 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new experimental medication called to see if it is safe, well-tolerated, and effective in treating advanced cancers that have specific genetic changes affecting DNA repair. The medication will be given as an oral pill to people with breast, ovarian, prostate, pancreatic, or brain cancers. Researchers will start with lower doses and gradually increase them to find the safest and most effective dose of the treatment.
Many advanced cancers have genetic changes that make them vulnerable to new types of treatments that target DNA repair. This medication is designed to take advantage of that vulnerability, but it has never been tested in humans before, so this trial will determine whether it is safe enough and effective enough to help people with these cancers.
You likely qualify if…
You likely don't qualify if…
You will take the experimental medication by mouth at a dose determined by when you join the trial and what dose level the study has reached. You will visit the study site regularly for check-ups, blood tests, and imaging scans to monitor how you are responding to the medication and to watch for any side effects. The trial has two phases: first, researchers will gradually increase doses to find the right level, and then additional participants will receive the dose that seems safest and most promising.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
United States
France