A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1% — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(282 sites) United States
Southern Arizona VA Health Care System, Tucson, Arizona Local Institution - 0112, Los Angeles, California University of California Davis (UC Davis) Comprehensive Cancer Center, Sacramento, California San Francisco Oncology Associates, San Francisco, California UCLA Hematology/Oncology - Santa Monica, Santa Monica, California University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami, Florida Memorial Hospital West, Pembroke Pines, Florida Florida Cancer Specialists - North, St. Petersburg, Florida Florida Cancer Specialists - East, West Palm Beach, Florida Affiliated Oncologists, LLC, Chicago Ridge, Illinois Local Institution - 0251, Wichita, Kansas Saint Elizabeth Medical Center Edgewood, Edgewood, Kentucky Local Institution - 0130, Lexington, Kentucky Hattiesburg Clinic Hematology/Oncology, Hattiesburg, Mississippi Local Institution - 0308, Bozeman, Montana Renown Regional Medical Center, Reno, Nevada Local Institution - 0346, Paterson, New Jersey Local Institution - 0381, Albuquerque, New Mexico Local Institution - 0356, Hawthorne, New York Veterans Affairs New York Harbor Healthcare System, New York, New York Local Institution - 0380, Northport, New York University of Rochester Medical Center, Rochester, New York SUNY Upstate Medical University, Syracuse, New York Local Institution - 0357, The Bronx, New York Local Institution - 0352, Asheville, North Carolina East Carolina University, Greenville, North Carolina Local Institution - 0369, Canton, Ohio University of Cincinnati Medical Center, Cincinnati, Ohio Local Institution - 0199, Cleveland, Ohio Local Institution - 0366, Massillon, Ohio Lancaster General Hospital - Ann B Barshinger Cancer Institute, Lancaster, Pennsylvania Texas Oncology - West Texas, Abilene, Texas Local Institution - 0305, Harlingen, Texas University of Texas MD Anderson Cancer Center, Houston, Texas The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center, Tyler, Texas Local Institution - 0302, Salt Lake City, Utah Argentina
Hospital Británico de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires Hospital Italiano de Buenos Aires, ABB, Buenos Aires F.D. Instituto Médico Río Cuarto, Río Cuarto, Córdoba Province Sanatorio Parque, Rosario, Santa Fe Province Hospital Privado Universitario de Córdoba, Córdoba Instituto Oncológico de Córdoba, Córdoba Hospital Privado de Comunidad, Mar del Plata Australia
Gosford Hospital, Gosford, New South Wales GenesisCare North Shore, St Leonards, New South Wales The Prince Charles Hospital, Brisbane, Queensland Gallipoli Medical Research Ltd, Brisbane, Queensland Local Institution - 0057, Elizabeth Vale, South Australia Box Hill Hospital, Box Hill, Victoria Fiona Stanley Hospital, Murdoch, Western Australia St. John of God Murdoch Hospital, Murdoch, Western Australia Austria
Universitätsklinikum Krems, Krems, Lower Austria Klinikum Wels-Grieskirchen GmbH, Wels, Upper Austria Klinik Floridsdorf, Vienna Belgium
Antwerp University Hospital, Edegem, Antwerpen UZ Brussel, Brussels, Bruxelles-Capitale, Région de Jessa Ziekenhuis, Hasselt, Limburg Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne, Yvoir, Namur AZ Delta vzw, Roeselare, West-Vlaanderen Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège Brazil
Pronutrir, Fortaleza, Ceará Cetus Oncologia - Unidade Belo Horizonte, Belo Horizonte, Minas Gerais CTO - Centro de Tratamento Oncológico, Belém, Pará Liga Norte Riograndense Contra o Câncer, Natal, Rio Grande do Norte Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul Hospital São Lucas da PUCRS, Porto Alegre, Rio Grande do Sul Clínica de Neoplasias Litoral, Itajaí, Santa Catarina Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, São Paulo NAIC - Instituto do Câncer, Bauru, São Paulo Centro de Oncologia - CEON+ - Unidade São Caetano do Sul, São Caetano do Sul, São Paulo Instituto Nacional de Câncer - INCA, Rio de Janeiro Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo Chile
Orlandi Oncologia, Santiago, Santiago Metropolitan Fundacion Arturo Lopez Perez (FALP), Santiago, Santiago Metropolitan Pontificia Universidad Catolica de Chile, Santiago, Santiago Metropolitan Bradfordhill, Santiago, Santiago Metropolitan Oncocentro Apys, Viña del Mar, Valparaiso China
Local Institution - 0182, Hefei, Anhui Beijing Cancer hospital, Beijing, Beijing Municipality Chongqing University Cancer Hospital, Chongqing, Chongqing Municipality Chongqing Three Gorges Central Hospital, Wanzhou, Chongqing Municipality Fujian Cancer Hospital, Fuzhou, Fujian The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Huizhou Central People's Hospital, Huizhou, Guangdong Liuzhou People's Hospital, Liuchow, Guangxi Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi Harbin Medical University Cancer Hospital, Harbin, Heilongjiang The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan Colombia
Local Institution - 0415, Medellín, Antioquia Local Institution - 0443, Bogotá, Bogota D.C. Local Institution - 0418, Bogotá, Bogota D.C. Local Institution - 0417, Valledupar, Cesar Department Local Institution - 0416, Pereira, Risaralda Department Local Institution - 0442, Cali, Valle del Cauca Department Denmark
Aarhus Universitetshospital, Skejby, Aarhus, Central Jutland Sygehus Soenderjylland, Sønderborg, Region Syddanmark Rigshospitalet, Copenhagen France
CHRU de Brest, Brest, Finistère CHU de Toulouse - Hopital Larrey, Toulouse, Haute-Garonne Local Institution - 0092, Montpellier, Hérault Local Institution - 0093, Rennes, Ille-et-Vilaine Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandœuvre-lès-Nancy, Meurthe-et-Moselle CHU Lille - Institut Coeur Poumon, Lille, Nord Centre Hospitalier intercommunal de Toulon La Seyne sur Mer, Toulon, Provence-Alpes-Côte d'Azur Region Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône Centre Hospitalier de la Côte Basque, Bayonne Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille Hopitaux Universitaires Paris Centre-Hopital Cochin, Paris Germany
Klinikum Esslingen, Esslingen am Neckar, Baden-Wurttemberg Bundeswehrkrankenhaus Ulm, Ulm, Baden-Wurttemberg Local Institution - 0287, Kempten (Allgäu), Bavaria Klinikum der Ludwig-Maximilians-Universitaet Muenchen, München, Bavaria Universitätsklinikum Marburg, Marburg, Hesse Praxis Onkologie am Raschplatz, Hanover, Lower Saxony Local Institution - 0469, Dortmund, North Rhine-Westphalia Evangelisches Krankenhaus Herne - Eickel, Herne, North Rhine-Westphalia Universitätsklinikum Münster - Albert Schweitzer Campus, Münster, North Rhine-Westphalia Klinikum Chemnitz, Chemnitz, Saxony LungenClinic Grosshansdorf, Großhansdorf, Schleswig-Holstein Local Institution - 0466, Lübeck, Schleswig-Holstein Charité Campus Virchow-Klinikum, Berlin India
Manipal Hospitals, Bengaluru, Karnataka Regional Cancer Centre - Thiruvananthapuram, Thiruvananthapuram, Kerala Mumbai Oncocare Centre Vile Parle, Mumbai, Maharashtra Tata Memorial Hospital, Mumbai, Maharashtra All India Institute of Medical Sciences, New Delhi, National Capital Territory of Delhi Local Institution - 0448, New Delhi, National Capital Territory of Delhi Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, National Capital Territory of Delhi Yashoda Hospital, Secunderabad, Telangana Narayana Superspecialty Hospital, Howrah, West Bengal Ireland
St. James's Hospital, Dublin Tallaght University Hospital, Dublin Local Institution - 0027, Dublin Italy
Instituto Tumori Giovanni Paolo II, Bari, Apulia Ospedale Santa Maria delle Croci, Ravenna, Emilia-Romagna Local Institution - 0045, Monza, Lombardy Local Institution - 0465, Milan, Milano A.O.R.N. Ospedale dei Colli - Monaldi V., Naples, Napoli Azienda Ospedaliera Di Rilievo Nazionale A. Cardarelli, Naples, Napoli Istituto Nazionale Tumori Regina Elena, Rome, Roma Casa di Cura Dott. Pederzoli, Peschiera del Garda, Verona Local Institution - 0222, Ravenna Japan
National Cancer Center Hospital East, Kashiwa, Chiba University of Occupational and Enviromental Health, Kitakyushu, Fukuoka Kurume University Hospital, Kurume, Fukuoka Chugoku Central Hospital, Fukuyama-shi, Hiroshima National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa Kanagawa cancer center, Yokohama, Kanagawa Kochi Medical School Hospital, Nankoku, Kochi Sendai Kousei Hospital, Sendai, Miyagi Nara Medical University Hospital, Kashihara, Nara Niigata Cancer Center Hospital, Niigata, Niigata Kurashiki Central Hospital, Kurashiki, Okayama-ken Kansai Medical University Hospital, Hirakata, Osaka
Mexico
Cancer Treamtent Clinic and Clinical Trials Sa de Cv, Guadalajara, Jalisco Arké SMO S.A. de C.V., México Hospital H+ Queretaro, Querétaro Centro Potosino de Investigación Médica, San Luis Potosí City Netherlands
Local Institution - 0030, Harderwijk, Gelderland Atrium-Orbis - Zuyderland Medisch Centrum Heerlen, Heerlen, Limburg Local Institution - 0196, 's-Hertogenbosch, North Brabant Local Institution - 0195, Zwolle, Overijssel Leids Universitair Medisch Centrum, Leiden, South Holland Local Institution - 0315, The Hague, South Holland Ziekenhuis Rijnstate, Arnhem Local Institution - 0032, Groningen New Zealand
Local Institution - 0407, Tauranga, Bay of Plenty Tauranga Hospital, Tauranga, Bay of Plenty Auckland City Hospital, Auckland Local Institution - 0425, Dunedin Local Institution - 0406, Wellington Poland
Local Institution - 0255, Konin, Greater Poland Voivodeship Centrum Medyczne Pratia Poznań, Poznan, Greater Poland Voivodeship Med-Polonia Sp. z o.o., Poznan, Greater Poland Voivodeship Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz, Kuyavian-Pomeranian Voivodeship Local Institution - 0259, Warsaw, Masovian Voivodeship Local Institution - 0257, Koszalin, West Pomeranian Voivodeship Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty Instytut Centrum Zdrowia Matki Polki, Lodz, Łódź Voivodeship Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Lisbon District Local Institution - 0404, Coimbra Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto Local Institution - 0401, Porto Romania
SC Memorial Healthcare International SRL, Bucharest, Bucharest Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu", Bucharest, Bucharest SC Radiotherapy Center Cluj SRL, Florești, Cluj Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj Institutul Oncologic Cluj, Cluj-Napoca Institutul Regional de Oncologie, Iași Spitalul Municipal Schuller Ploiești, Ploieşti Saudi Arabia
Local Institution - 0440, Dammam, Eastern Province Local Institution - 0409, Jeddah, Makkah Al Mukarramah Local Institution - 0408, Riyadh, Riyadh Region South Africa
Local Institution - 0431, Soweto, Gauteng Local Institution - 0429, Johannesburg, GP Life Groenkloof, Pretoria, GP Sandton Oncology Medical Group (Pty) Ltd, Sandton, GP Cape Town Oncology Trials, Cape Town, Western Cape South Korea
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk] Gachon University Gil Medical Center, Namdong-gu, Incheon-gwangyeoksi [Incheon] Chonnam National University Hwasun Hospital, Hwasun, Jeonranamdo National Cancer Center, Goyang-si, Kyǒnggi-do CHA Bundang Medical Center, CHA University, Seongnam-si, Kyǒnggi-do Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul] Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul] Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul] Spain
CHUAC-Hospital Teresa Herrera, A Coruña, A Coruña [La Coruña] Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona] Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya [Cataluña] Local Institution - 0267, L'Hospitalet de Llobregat, Catalunya [Cataluña] Hospital Son Llàtzer, Palma, Illes Balears [Islas Baleares] Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad de Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad de Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad de Local Institution - 0411, Valencia, València H.R.U Málaga - Hospital General, Málaga Hospital Universitario Virgen Del Rocio, Seville Local Institution - 0269, Valencia Switzerland
Local Institution - 0291, Lausanne, Canton of Vaud Local Institution - 0341, Bellinzona, Canton Ticino Local Institution - 0290, Basel Local Institution - 0398, Münsterlingen Taiwan
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist, Kaohsiung Taipei Medical University Shuang Ho Hospital, New Taipei City Taichung Veterans General Hospital, Taichung National Taiwan University Hospital, Taipei Taipei Veterans General Hospital, Taipei Turkey (Türkiye)
Local Institution - 0361, Adana Local Institution - 0365, Adana Local Institution - 0383, Ankara Local Institution - 0362, Ankara Local Institution - 0410, Istanbul Local Institution - 0364, Istanbul United Kingdom
Local Institution - 0441, Exeter, Devon Local Institution - 0349, Dundee, Dundee City Forth Valley Royal Hospital, Larbert, Falkirk Local Institution - 0189, Glasgow, Glasgow City Local Institution - 0021, London, Kensington and Chelsea Leicester Royal Infirmary, Leicester, Leicestershire St Bartholomew's Hospital, London, London, City of Local Institution - 0001, London, London, City of Sarah Cannon Research Institute UK, London Local Institution - 0020, Manchester Local Institution - 0024, Metropolitan Borough of Wirral Royal Berkshire Hospital, Reading Key details Sponsor
Bristol-Myers Squibb
Enrollment target
~1,000 participants
Primary completion
July 2030
Age range
18 Years and older
Last updated March 2026
Interested in joining? Local Institution - 0237, Zhengzhou, Henan
Local Institution - 0235, Wuhan, Hubei Hunan Cancer Hospital, Changsha, Hunan First Huai'an Hospital Affiliated to Nanjing Medical University, Huai'an, Jiangsu The First affiliated hospital of Nanchang University (Xianghu campus), Nanchang, Jiangxi Liaoning Cancer Hospital, Shenyang, Liaoning Xi'an International Medical Center Hospital, Xi'an, Shaanxi Shandong Cancer Hospital, Jinan, Shandong Shanghai Chest Hospital, Shanghai, Shanghai Municipality Shanghai Chest Hospital, Shanghai, Shanghai Municipality Zhongshan Hospital,Fudan University, Shanghai, Shanghai Municipality Shanxi Cancer Hospital, Taiyuan, Shanxi Sichuan Cancer hospital, Chengdu, Sichuan The Second People's Hospital of Neijiang, Neijiang, Sichuan Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin Municipality The first Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Zhejiang Cancer Hospital, Hangzhou, Zhejiang Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang Guangdong Provincial People's Hospital, Guangzhou Universitätsklinikum Bonn, Bonn Universitaetsklinikum Essen, Essen Asklepios Klinik Gauting GmbH, Gauting Kindai University Hospital, Sakai, Osaka
Saitama Medical University International Medical Center, Hidaka, Saitama Hamamatsu University Hospital, Hamamatsu, Shizuoka Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun, Shizuoka The Cancer Institute Hospital of JFCR, Koto, Tokyo Hyogo Cancer Center, Akashi Fukushima Medical University, Fukushima Osaka International Cancer Institute, Osaka