A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS). — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(184 sites) United States
Southern Cancer Center, PC, Daphne, Alabama Local Institution - 0283, Hot Springs, Arkansas Florida Cancer Specialists - South, Fort Myers, Florida Mid Florida Hematology and Oncology Center, Orange City, Florida Florida Cancer Specialists - North, St. Petersburg, Florida Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Marietta, Georgia Illinois Cancer Care, Peoria, Illinois Local Institution - 0037, Minneapolis, Minnesota University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico Duke Cancer Institute, Durham, North Carolina Local Institution - 0232, Bismarck, North Dakota Local Institution - 0010, Fargo, North Dakota Oncology Hematology Care, Cincinnati, Ohio Sanford Cancer Center, Sioux Falls, South Dakota SCRI Oncology Partners, Nashville, Tennessee Texas Oncology - Central/South Texas, Austin, Texas Texas Oncology - Northeast Texas, Tyler, Texas Oncology & Hematology Associates of Southwest Virginia, Inc., Roanoke, Virginia Swedish Cancer Institute - Edmonds, Edmonds, Washington Swedish Medical Center, Seattle, Washington Argentina
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires Hospital Italiano de Buenos Aires, ABB, Buenos Aires F.D. Local Institution - 0100, Buenos Aires, Buenos Aires F.D. Clinica Adventista Belgrano, CABA, Buenos Aires F.D. Instituto Médico Río Cuarto, Río Cuarto, Córdoba Province Australia
GenesisCare - Campbelltown, Campbelltown, New South Wales Nepean Hospital, Penrith, New South Wales Gallipoli Medical Research Ltd, Brisbane, Queensland Grampians Health, Ballarat Central, Victoria St. John of God Murdoch Hospital, Murdoch, Western Australia Austria
Medizinische Universität Graz, Graz, Styria Klinikum Wels-Grieskirchen GmbH, Wels, Upper Austria Kepler Universitätsklinikum, Linz Landeskrankenhaus Rankweil, Rankweil Belgium
Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région de UZ Gent, Ghent, Oost-Vlaanderen VITAZ, Sint-Niklaas, Oost-Vlaanderen Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège Brazil
Hospital São Carlos, Fortaleza, Ceará Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul Hospital São Lucas da PUCRS, Porto Alegre, Rio Grande do Sul Instituto de Oncologia Saint Gallen, Santa Cruz do Sul, Rio Grande do Sul Clínica de Neoplasias Litoral, Itajaí, Santa Catarina Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, São Paulo A. C. Camargo Cancer Center, São Paulo, São Paulo Canada
Cross Cancer Institute, Edmonton, Alberta CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Quebec Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski, Rimouski, Quebec Chile
Orlandi Oncologia, Santiago, Santiago Metropolitan Fundacion Arturo Lopez Perez (FALP), Santiago, Santiago Metropolitan Pontificia Universidad Catolica de Chile, Santiago, Santiago Metropolitan Bradfordhill, Santiago, Santiago Metropolitan Oncocentro Apys, Viña del Mar, Valparaiso China
Peking University Cancer Hospital Beijing Cancer Hospital Beijing Institute for Cancer Research, Beijing, Beijing Municipality Beijing Chest Hospital,Capital Medical University, Beijing, Beijing Municipality Chongqing University Cancer Hospital, Chongqing, Chongqing Municipality Fujian Cancer Hospital, Fuzhou, Fujian The First Affiliated hospital of Xiamen University, Xiamen, Fujian Cancer Hospital of Shantou University Medical College, Shantou, Guangdong Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Hubei Cancer Hospital, Wuhan, Hubei Wuhan Tongji Hospital, Wuhan, Hubei Hunan Cancer Hospital, Changsha, Hunan The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Jilin Province Tumor Hospital, Changchun, Jilin Czechia
Masarykuv onkologicky ustav, Brno, Brno-město Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava, Ostrava Město Fakultni Thomayerova nemocnice, Prague, Praha 4 Fakultni nemocnice Olomouc, Olomouc France
Hôpital Arnaud de Villeneuve - CHU Montpellier, Montpellier, Hérault Chu Grenoble Alpes, La Tronche, Isère CHU Lille - Institut Coeur Poumon, Lille, Nord L Hopital Nord Ouest, Gleizé, Rhône Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône Centre Hospitalier Intercommunal de Créteil, Créteil, Val-de-Marne Gustave Roussy, Villejuif, Val-de-Marne Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille Centre Hospitalier de Cornouaille Quimper - Concarneau, Quimper Germany
Krankenhaus Nordwest GmbH, Frankfurt am Main, Hesse Pius Hospital Oldenburg, Oldenburg, Lower Saxony Klinikum Köln-Merheim, Cologne, North Rhine-Westphalia Krankenhaus Martha-Maria Halle-Dölau, Halle, Saxony-Anhalt Zentralklinik Bad Berka, Bad Berka, Thuringia Asklepios Klinik Gauting GmbH, Gauting LungenClinic Grosshansdorf, Großhansdorf Thoraxklinik-Heidelberg gGmbH, Heidelberg Robert Bosch Krankenhaus GmbH, Stuttgart Greece
Errikos Dunant Hospital Center, Athens, Attikí Thoracic General Hospital of Athens "I Sotiria", Athens, Attikí "Theagenio" Cancer Hospital of Thessaloniki, Thessaloniki, Kentrikí Makedonía European Interbalkan Medical Center, Thessaloniki, Thessaloníki University General Hospital of Larissa, Larissa, Thessalía India
Manipal Hospitals, Bengaluru, Karnataka Local Institution - 0278, New Delhi, National Capital Territory of Delhi Meenakshi Mission Hospital and Research Centre, Madurai, Tamil Nadu Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi, Uttar Pradesh Netaji Subhas Chandra Bose Cancer Hospital, Kolkata, West Bengal Italy
Local Institution - 0072, Naples, Campania Local Institution - 0068, Milan, Lombardy Local Institution - 0069, Rome, Roma Local Institution - 0110, Perugia, Umbria Local Institution - 0070, Peschiera del Garda, Verona Local Institution - 0074, Bologna Local Institution - 0067, Milan Japan
National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime Kurume University Hospital, Kurume, Fukuoka Hokkaido University Hospital, Sapporo, Hokkaido Kobe City Medical Center General Hospital, Kobe, Hyōgo Kanazawa University Hospital, Kanazawa, Ishikawa-ken Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa Sendai Kousei Hospital, Sendai, Miyagi Nara Medical University Hospital, Kashihara, Nara Kurashiki Central Hospital, Kurashiki, Okayama-ken Kansai Medical University Hospital, Hirakata, Osaka Kindai University Hospital, Ōsaka-sayama, Osaka Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka Saitama Medical University International Medical Center, Hidaka, Saitama Malaysia
Hospital Kuala Lumpur, Kuala Lumpur, Kuala Lumpur University Malaya Medical Centre, Kuala Lumpur, Kuala Lumpur Sarawak General Hospital, Kuching, Sarawak Mexico
Centro Inmuno-Oncología Occidente, Guadalajara, Jalisco Local Institution - 0147, Monterrey, Nuevo León Unidad Médica Onco-hematológica, Puebla City Netherlands
Amsterdam UMC, locatie VUmc, Amsterdam, North Holland Ziekenhuis Rijnstate, Arnhem University Medical Center Groningen, Groningen Poland
Przychodnia Lekarska KOMED, Konin, Greater Poland Voivodeship Centrum Medyczne Pratia Poznań, Poznan, Greater Poland Voivodeship Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty, Pomeranian Voivodeship Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz Instytut Centrum Zdrowia Matki Polki, Lodz, Łódź Voivodeship Romania
SC Memorial Healthcare International SRL, Bucharest, Bucharest Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu", Bucharest, Bucharest SC Radiotherapy Center Cluj SRL, Florești, Cluj Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj Institutul Oncologic Cluj, Cluj-Napoca S.C. Centrul de Oncologie Euroclinic S.R.L., Iași Institutul Regional de Oncologie, Iași South Korea
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk] Seoul National University Bundang Hospital, Seongnam, Kyǒnggi-do Ajou University Hospital, Suwon, Kyǒnggi-do Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul] Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul] Keimyung University Dongsan Hospital, Daegu, Taegu-Kwangyǒkshi Spain
CHUS - Hospital Clinico Universitario, Santiago de Compostela, A Coruña [La Coruña] Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña] Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya [Cataluña] Hospital Universitario de Jaen, Jaén, Jaén Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad de Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad de Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad de Hospital General Universitario de Valencia, Valencia, Valenciana, Comunitat Hospital Universitario Virgen Macarena, Seville Hospital Universitario Virgen Del Rocio, Seville Switzerland
Kantonsspital Graubünden, Chur Kantonsspital Winterthur, Winterthur UniversitätsSpital Zürich, Zurich Turkey (Türkiye)
T.C. Saglik Bakanligi - Izmir Il Saglik Mudurlugu Cigli Bolge Egitim Hastanesi, Çiğli, İzmir Adana City Hospital, Adana Gulhane Egitim Arastirma Hastanesi, Ankara Atatürk Göğüs Hastalıkları Ve Göğüs Cerrahisi Eğitim Araştırma Hastanesi, Ankara Istanbul Medeniyet University, Istanbul United Kingdom
James Cook University Hospital, Central Middlesbrough, Middlesbrough Aberdeen Royal Infirmary, Aberdeen The Christie NHS Foundation Trust, Manchester The Clatterbridge Cancer Centre, Metropolitan Borough of Wirral Key details Sponsor
Bristol-Myers Squibb
Enrollment target
~530 participants
Primary completion
April 2028
Age range
18 Years and older
Last updated April 2026
Interested in joining? Local Institution - 0235, Shenyang, Liaoning
Xi'an International Medical Center Hospital, Xi'an, Shaanxi Shandong Cancer Hospital, Jinan, Shandong Shanghai Chest Hospital, Shanghai, Shanghai Municipality Zhongshan Hospital,Fudan University, Shanghai, Shanghai Municipality Shanghai East Hospital, Shanghai, Shanghai Municipality Sichuan Cancer hospital, Chengdu, Sichuan Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin Municipality Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Zhejiang Cancer Hospital, Hangzhou, Zhejiang Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang Saitama Prefectural Cancer Center, Ina-machi, Saitama Hamamatsu University Hospital, Hamamatsu, Shizuoka Nippon Medical School Hospital, Bunkyo-ku, Tokyo The Cancer Institute Hospital of JFCR, Koto, Tokyo Fukushima Medical University, Fukushima