Recruiting

Using fat cells to treat chronic heart failure

Plain-English translation of NCT06705023 on ClinicalTrials.gov ↗ · Source last updated December 2024 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This study is testing a new approach to treating chronic heart failure using —cells collected from your own fat tissue. Doctors will harvest a small amount of fat from your abdomen or thigh, isolate special healing cells from it, and then inject those cells directly into your heart's blood vessels using a catheter. The trial will compare this new treatment to standard heart failure medications to see if it can improve how well your heart pumps blood.

Many people with chronic heart failure continue to struggle even while taking the best available medications. This trial is exploring whether regenerative cells from a patient's own body could help repair damaged heart tissue and improve heart function in ways that current medications cannot.

Do you qualify?

You likely qualify if…

you have been diagnosed with heart failure caused by coronary artery disease with an ejection fraction of 40% or lower despite being on stable heart failure medications
you have New York Heart Association class I, II, or III heart failure symptoms
you have been receiving guideline-recommended heart failure medications at stable doses for at least one month before enrolling
you are a candidate for right heart catheterization (a diagnostic procedure where a thin tube is passed through a vein to the heart)
if you are a woman of childbearing age, you are willing to use birth control during the study and willing to take a pregnancy test

You likely don't qualify if…

you have had a heart procedure (like stent placement or bypass surgery) within the past three months
you have severe heart valve disease, a mechanical or artificial heart valve, or certain pacemaker or defibrillator conditions that would make the imaging tests unsafe
you have had a stroke within the past three months or a blood clot in your left ventricle
you have severe kidney disease, uncontrolled diabetes, or significant blood count abnormalities
you have received any other cell or gene therapy within the past 12 months

What participation looks like

If assigned to the treatment group, you would first have an outpatient liposuction procedure under light sedation to collect fat tissue from your abdomen or thighs. The harvested fat would then be processed to extract the regenerative cells, which would be tested for quality before being injected into your heart during a cardiac catheterization procedure. If assigned to the control group, you would continue your current heart failure medications. The study will track your heart function and overall health over the course of the trial.

AI-generated summary from trial data · Jun 14, 2026 · Not medical advice

Using fat cells to treat chronic heart failure

What is this trial?

Do you qualify?

What participation looks like

Trial locations