A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103) — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(159 sites) United States
University of Alabama at Birmingham ( Site 0006), Birmingham, Alabama Alaska Women's Cancer Care ( Site 0096), Anchorage, Alaska Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 0001), New Haven, Connecticut Mount Sinai Cancer Center ( Site 0078), Miami Beach, Florida Sarasota Memorial Hospital ( Site 0075), Sarasota, Florida Florida Cancer Specialists East ( Site 7000), West Palm Beach, Florida Winship Cancer Institute of Emory University ( Site 0086), Atlanta, Georgia Augusta University - Georgia Cancer Center ( Site 0066), Augusta, Georgia Parkview Research Center at Parkview Regional Medical Center ( Site 0003), Fort Wayne, Indiana Women's Cancer Care ( Site 0067), Covington, Louisiana Maine Medical Center Research Institute-MaineHealth/Maine Medical Partners - GynOnc ( Site 0008), Scarborough, Maine St. Dominic's Hospital ( Site 0064), Jackson, Mississippi Nebraska Methodist Hospital ( Site 0053), Omaha, Nebraska John Theurer Cancer Center at Hackensack University Medical Center ( Site 0081), Hackensack, New Jersey Rutgers Cancer Institute of New Jersey ( Site 0071), New Brunswick, New Jersey University of New Mexico Comprehensive Cancer Center ( Site 0055), Albuquerque, New Mexico NYU Langone Hospital - Long Island ( Site 0015), Mineola, New York Laura and Isaac Perlmutter Cancer Center ( Site 0076), New York, New York FirstHealth Cancer Center ( Site 0079), Pinehurst, North Carolina University of Cincinnati Medical Center ( Site 0090), Cincinnati, Ohio Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0056), Tulsa, Oklahoma Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8010), Eugene, Oregon Women & Infants Hospital ( Site 0050), Providence, Rhode Island Henry-Joyce Cancer Clinic ( Site 0060), Nashville, Tennessee Texas Oncology - Central/South Texas ( Site 8009), Austin, Texas Texas Oncology - DFW ( Site 8001), Fort Worth, Texas Texas Oncology - San Antonio ( Site 8005), San Antonio, Texas Texas Oncology - Gulf Coast ( Site 8003), Webster, Texas Virginia Cancer Specialists (VCS) ( Site 8011), Fairfax, Virginia Argentina
Instituto Alexander Fleming ( Site 2909), Ciudad Autónoma de Buenos Aires, Buenos Aires Instituto de Investigaciones Clinicas Mar del Plata ( Site 2901), Mar del Plata, Buenos Aires Fundación Respirar ( Site 2912), Buenos Aires, Buenos Aires F.D. Instituto de Oncologia de Rosario ( Site 2910), Rosario, Santa Fe Province Hospital Aleman ( Site 2903), CABA Hospital Italiano de Cordoba ( Site 2908), Córdoba Australia
Blacktown Hospital ( Site 0211), Sydney, New South Wales Gallipoli Medical Research Ltd ( Site 0214), Brisbane, Queensland Epworth Freemasons ( Site 0217), East Melbourne, Victoria Frankston Hospital ( Site 0216), Frankston, Victoria Belgium
Antwerp University Hospital ( Site 0304), Edegem, Antwerpen Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman ( Site 0306), Liège, Liege AZ Sint-Lucas ( Site 0305), Ghent, Oost-Vlaanderen CHU UCL Namur/Site Sainte Elisabeth ( Site 0302), Ghent, Oost-Vlaanderen UZ Leuven ( Site 0301), Leuven, Vlaams-Brabant Brazil
Liga Norte Riograndense Contra o Cancer ( Site 0423), Natal, Rio Grande do Norte ANIMI - Unidade de Tratamento Oncologico ( Site 0419), Lages, Santa Catarina Hospital Paulistano ( Site 0421), São Paulo IBCC - Núcleo de Pesquisa e Ensino ( Site 0424), São Paulo Canada
Princess Margaret Cancer Centre ( Site 0518), Toronto, Ontario McGill University Health Centre ( Site 0502), Montreal, Quebec Chile
Clinica Puerto Montt ( Site 0615), Port Montt, Los Lagos Region ONCOCENTRO APYS-ACEREY ( Site 0612), Viña del Mar, Valparaiso Colombia
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0806), Bogotá, Bogota D.C. Instituto Nacional De Cancerologia ( Site 0807), Bogotá, Bogota D.C. Oncologos Del Occidente ( Site 0805), Pereira, Risaralda Department Czechia
Fakultni nemocnice Ostrava ( Site 3323), Ostrava-Poruba, Ostrava Mesto Vseobecna fakultni nemocnice v Praze ( Site 3325), Prague Fakultni nemocnice v Motole ( Site 3322), Prague Denmark
Rigshospitalet ( Site 0904), Copenhagen, Capital Region Herlev Hospital ( Site 0903), Herlev, Capital Region Aalborg Universitetshospital ( Site 0901), Aalborg, North Denmark Vejle Sygehus ( Site 0902), Vejle, Region Syddanmark Finland
Oulun yliopistollinen sairaala ( Site 1003), Oulu, North Ostrobothnia Kuopion Yliopistollinen Sairaala ( Site 1004), Kuopio, Northern Savonia Tampereen yliopistollinen sairaala ( Site 1002), Tampere, Pirkanmaa France
Centre Oscar Lambret ( Site 1104), Lille, Ain Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1101), Bordeaux, Aquitaine Centre Hopitalier Lyon Sud ( Site 1110), Pierre-Bénite, Auvergne-Rhône-Alpes Centre Francois Baclesse ( Site 1108), Caen, Calvados Hôpital Privé Des Côtes d'Armor ( Site 1106), Plérin, Cotes-d Armor Oncopole Claudius Regaud ( Site 1109), Toulouse, Haute-Garonne Pôle Santé Léonard de Vinci ( Site 1112), Chambray-lès-Tours, Indre-et-Loire Groupe Hospitalier Broca Cochin Hotel Dieu ( Site 1111), Paris, Paris Institut De Cancerologie De L Ouest ( Site 1107), Saint-Herblain, Pays de la Loire Region Sainte Catherine Institut du Cancer Avignon Provence ( Site 1105), Avignon, Vaucluse Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 1102), Paris Greece
Aretaieio Hospital ( Site 0701), Athens, Attica Hungary
Bacs-Kiskun Megyei Korhaz ( Site 3920), Kecskemét, Bács-Kiskun county Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Onkoterapias Klinika ( Site 3924), Szeged, Csongrád megye Debreceni Egyetem Klinikai Kozpont ( Site 3922), Debrecen, Hajdú-Bihar Israel
Hillel Yaffe Medical Center ( Site 1404), Hadera Rambam Health Care Campus ( Site 1402), Haifa Shaare Zedek Medical Center ( Site 1405), Jerusalem Meir Medical Center. ( Site 1403), Kfar Saba Sheba Medical Center ( Site 1401), Ramat Gan Italy
CRO-IRCCS ( Site 1510), Aviano, Friuli Venezia Giulia Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1507), Milan, Milano Azienda Ospedaliero Universitaria Pisana ( Site 1504), Pisa, Tuscany Instituto Tumori Giovanni Paolo II ( Site 1505), Bari Istituto Europeo di Oncologia ( Site 1506), Milan Humanitas San Pio X Hospital ( Site 1503), Milan Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1501), Naples Istituto Oncologico Veneto IRCCS ( Site 1508), Padova Fondazione Policlinico Universitario Agostino Gemelli ( Site 1502), Roma Ospedale Mauriziano ( Site 1509), Torino Japan
Aichi Cancer Center ( Site 1626), Nagoya, Aichi-ken National Hospital Organization Shikoku Cancer Center ( Site 1631), Matsuyama, Ehime Ehime University Hospital ( Site 1637), Tōon, Ehime Kurume University Hospital ( Site 1640), Kurume, Fukuoka Gunma Prefectural Cancer Center ( Site 1630), Ōta, Gunma Hokkaido University Hospital ( Site 1634), Sapporo, Hokkaido Iwate Medical University Hospital ( Site 1635), Shiwa-gun, Iwate Saitama Medical University International Medical Center ( Site 1632), Hidaka, Saitama Cancer Institute Hospital of JFCR ( Site 1639), Koto, Tokyo Keio University Hospital ( Site 1636), Shinjyuku, Tokyo National Hospital Organization Kyushu Cancer Center ( Site 1628), Fukuoka Kagoshima City Hospital ( Site 1638), Kagoshima Mexico
CIO - Centro de Inmuno-Oncología de Occidente ( Site 1719), Guadalajara, Jalisco Higiea Oncologia ( Site 1713), Mexico City, Mexico City Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 1711), Monterrey, Nuevo León I CAN ONCOLOGY CENTER S.A. DE C.V. ( Site 1716), Monterrey, Nuevo León Servicios de Oncología Médica Integral - Monterrey ( Site 1712), Monterrey, Nuevo León Centro de Investigación Oncológica Galerías SC ( Site 1720), Aguascalientes Cryptex Investigación Clínica S.A. de C.V. ( Site 1715), Cuauhtémoc COI Centro Oncologico Internacional S.A.P.I. de C.V. ( Site 1717), Mexico City Centro de Investigacion Clinica de Oaxaca ( Site 1714), Oaxaca City Peru
Hospital Guillermo Almenara Irigoyen ( Site 3608), Lima IPOR Instituto Peruano de Oncología & Radioterapia ( Site 3604), Lima INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 3601), Lima Clínica San Felipe ( Site 3603), Lima Poland
Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2106), Poznan, Greater Poland Voivodeship Bialostockie Centrum Onkologii ( Site 2104), Bialystok, Podlaskie Voivodeship Swietokrzyskie Centrum Onkologii. ( Site 2105), Kielce, Świętokrzyskie Voivodeship Portugal
Hospital da Luz ( Site 3802), Lisbon Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 3801), Porto Romania
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2215), Cluj-Napoca, Cluj S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2211), Craiova, Dolj Cabinet Medical Oncomed ( Site 2217), Timișoara, Timiș County Spitalul Clinic Filantropia ( Site 2213), Bucharest South Korea
National Cancer Center ( Site 2305), Goyang-si, Kyonggi-do Severance Hospital ( Site 2302), Seodaemun-Gu, Seoul Asan Medical Center ( Site 2304), Songpa-gu, Seoul Seoul National University Hospital ( Site 2301), Seoul Samsung Medical Center ( Site 2303), Seoul Spain
Institut Català d'Oncologia (ICO) - Girona ( Site 2402), Girona, Gerona Hospital General Gregorio Maranon de Madrid ( Site 2412), Madrid, Madrid, Comunidad de Clinica Universidad de Navarra ( Site 2407), Madrid, Madrid, Comunidad de Hosp Clinico Universitario de Valencia ( Site 2401), Valencia, Valenciana, Comunitat Hospital Vall D Hebron ( Site 2403), Barcelona Hospital Clinic I Provincial de Barcelona ( Site 2409), Barcelona ICO L Hospitalet ( Site 2408), Barcelona Hospital Universitario Reina Sofia ( Site 2406), Córdoba Hospital Ramon y Cajal ( Site 2405), Madrid Hospital Clinico San Carlos... ( Site 2410), Madrid Hospital Universitario 12 de Octubre ( Site 2411), Madrid Hospital Universitario La Paz ( Site 2404), Madrid Taiwan
Taichung Veterans General Hospital ( Site 2603), Taichung National Cheng Kung University Hospital ( Site 2602), Tainan National Taiwan University Hospital ( Site 2601), Taipei Mackay Memorial Hospital ( Site 2604), Taipei Chang Gung Memorial Hospital - Linkou Branch ( Site 2605), Taoyuan District Thailand
Ramathibodi Hospital ( Site 3402), Bangkok, Bangkok Faculty of Medicine Siriraj Hospital ( Site 3401), Bangkok, Bangkok United Kingdom
Western General Hospital ( Site 2806), Edinburgh, Edinburgh, City of ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 2801), London, London, City of Royal Marsden Hospital (Sutton) ( Site 2802), Sutton, London, City of Leicester Royal Infirmary ( Site 2808), Leicester
Key details Sponsor
Merck Sharp & Dohme LLC
Collaborators
European Network of Gynaecological Oncological Trial Groups (ENGOT), GOG Foundation
Enrollment target
~770 participants
Primary completion
April 2029
Niigata Cancer Center Hospital ( Site 1633), Niigata
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 1629), Osaka Age range
18 Years and older