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Testing a New Blood Clot Prevention Drug After Knee Surgery

Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.

What is this trial?

This completed trial tested a new injection called SHR-2004 to see if it could safely prevent dangerous blood clots after knee replacement surgery. Researchers compared this new drug against a standard treatment to find out which one worked better and was safer for patients.

Blood clots are a serious risk after knee replacement surgery, and doctors need effective ways to prevent them. This trial examined whether SHR-2004 could be a better or safer option than existing treatments.

What participation looks like

Participants received either the new SHR-2004 injection or a standard blood clot prevention treatment, though they didn't know which one they received. The trial followed patients through their knee surgery and recovery period, monitoring them with imaging scans to check whether blood clots developed. The study involved approximately 1,166 patients across multiple medical centers.

AI-generated summary from trial data · Apr 17, 2026 · Not medical advice

Trial locations(2 sites)

China

Fourth Medical Center of Chinese People's Liberation Army General Hospital, Beijing, Beijing Municipality
Xiangya Hospital, Central South University, Changsha, Hunan

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