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Testing probiotics to prevent repeat urinary tract infections

Not a traditional drug trial — this study doesn't follow the standard phase structure.

What is this trial?

This completed trial tested whether taking a specific probiotic called Lactobacillus crispatus, combined with another probiotic product, could help prevent repeat urinary tract infections (UTIs) better than standard treatment alone. Researchers followed women for a year to see if this probiotic approach reduced how often they experienced these painful infections.

Repeat UTIs are a major problem for many women, and doctors typically treat them with antibiotics. However, repeated antibiotic use can create resistant bacteria and throw off the healthy bacteria in your body, sometimes making infections more likely to come back. This trial investigated whether probiotics—beneficial bacteria—could help restore your natural defenses and reduce your need for antibiotics.

What participation looks like

Participants were divided into two groups. One group took a probiotic powder (iNatal Duo) once daily for one month, plus an additional probiotic supplement (CRISPACT) for three months. The other group took only iNatal Duo for one month. All participants were then followed for a full year, during which researchers tracked how many UTIs they experienced, how their symptoms improved, and how the probiotics affected their quality of life.

AI-generated summary from trial data · Apr 17, 2026 · Not medical advice

Trial locations(1 site)

Italy

Medicine & Technological Innovation Dept. University of Insubria, Varese

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