A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4) — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(346 sites) United States
Local Institution - 0347, Birmingham, Alabama Local Institution - 0686, Springdale, Arkansas Local Institution - 0581, Fullerton, California Local Institution - 0682, Loma Linda, California Helios Clinical Research, Long Beach, California Local Institution - 0623, Santa Barbara, California Local Institution - 0442, Denver, Colorado Local Institution - 0052, Jacksonville, Florida Local Institution - 0680, Ocala, Florida Local Institution - 0679, Orange City, Florida Local Institution - 0621, Palm Bay, Florida Local Institution - 0365, Plantation, Florida Local Institution - 0695, St. Petersburg, Florida Florida Clinical Trials Group., Tamarac, Florida Local Institution - 0647, Tampa, Florida Local Institution - 0031, Marietta, Georgia Local Institution - 0665, Arlington Heights, Illinois Local Institution - 0676, Chicago, Illinois Local Institution - 0683, Springfield, Illinois Local Institution - 0454, Dyer, Indiana Local Institution - 0684, Fort Wayne, Indiana Local Institution - 0423, Munster, Indiana Local Institution - 0366, Edgewood, Kentucky Local Institution - 0566, Louisville, Kentucky Local Institution - 0693, Owensboro, Kentucky Local Institution - 0698, Paducah, Kentucky Local Institution - 0644, Shreveport, Louisiana Local Institution - 0691, Baltimore, Maryland Local Institution - 0385, Columbia, Maryland Local Institution - 0019, Boston, Massachusetts Local Institution - 0293, Detroit, Michigan Local Institution - 0685, Fenton, Missouri Local Institution - 0678, Cooperstown, New York Local Institution - 0689, Rochester, New York Local Institution - 0634, Schenectady, New York Local Institution - 0618, White Plains, New York Local Institution - 0624, Asheville, North Carolina Local Institution - 0672, Salisbury, North Carolina Local Institution - 0688, Easton, Pennsylvania WellSpan Oncology Research, York, Pennsylvania Local Institution - 0681, Greenville, South Carolina Local Institution - 0658, Greenville, South Carolina Local Institution - 0020, Nashville, Tennessee Local Institution - 0697, Nashville, Tennessee Local Institution - 0692, Galveston, Texas Local Institution - 0652, Laredo, Texas Local Institution - 0622, San Antonio, Texas Argentina
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires IDIM - Instituto de Investigaciones Metabólicas, Ciudad de Buenos Aires, Buenos Aires Hospital Universitario Austral, Pilar, Buenos Aires Hospital Italiano de Buenos Aires, ABB, Buenos Aires F.D. Local Institution - 0571, Buenos Aires, Buenos Aires F.D. Clinica Adventista Belgrano, CABA, Buenos Aires F.D. Sanatorio Plaza, Rosario, Santa Fe Province Australia
Canberra Hospital, Canberra, Australian Capital Territory Tamworth Hospital, North Tamworth, New South Wales Orange Hospital, Orange, New South Wales Princess Alexandra Hospital, Brisbane, Queensland Lyell McEwin Hospital, Elizabeth Vale, South Australia Frankston Hospital, Frankston, Victoria Northern Hospital, Melbourne, Victoria Latrobe Regional Health, Traralgon, Victoria Joondalup Health Campus, Joondalup, Western Australia Austria
Medizinische Universität Graz, Graz, Styria Klinikum Wels-Grieskirchen GmbH, Wels, Upper Austria Kepler Universitätsklinikum, Linz Medizinische Universität Wien, Vienna Local Institution - 0673, Vienna Belgium
UZ Brussel, Brussels, Bruxelles-Capitale, Région de Cliniques universitaires Saint-Luc, Brussels, Bruxelles-Capitale, Région de Jessa Ziekenhuis, Hasselt, Limburg AZ Maria Middelares, Ghent, Oost-Vlaanderen UZ Leuven, Leuven, Vlaams-Brabant Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège Brazil
CEDOES, Vitória, Espírito Santo Nucleo de Oncologia da Bahia, Salvador, Estado de Bahia Cetus Oncologia - Unidade Belo Horizonte, Belo Horizonte, Minas Gerais ONCOSITE - Centro de Pesquisa Clinica em Oncologia, Ijuí, Rio Grande do Sul Hospital São Lucas da PUCRS, Porto Alegre, Rio Grande do Sul Instituto de Oncologia Saint Gallen, Santa Cruz do Sul, Rio Grande do Sul Hospital de Amor Amazônia, Porto Velho, Rondônia Clínica de Oncologia Reichow, Blumenau, Santa Catarina Clínica de Neoplasias Litoral, Itajaí, Santa Catarina Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, São Paulo Advanze Pesquisa, São Carlos, São Paulo Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo Bulgaria
MBAL Uni Hospital, Panagyurishte, Pazardzhik Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia, Sofia (stolitsa) Complex Oncology Center - Ruse EOOD, Rousse Trakia Hospital, Stara Zagora Canada
Local Institution - 0074, Halifax, Nova Scotia Local Institution - 0559, Montreal, Quebec Chile
Bradfordhill, Recoleta, Santiago Metropolitan FALP, Santiago, Santiago Metropolitan China
The First Afflilated Hospital of Bengbu Medical College, Bengbu, Anhui Anhui Provincial Hospital, Hefei, Anhui Beijing Cancer hospital, Beijing, Beijing Municipality Beijing Peking Union Medical College Hospital, Beijing, Beijing Municipality Beijing Chest Hospital,Capital Medical University, Beijing, Beijing Municipality Chongqing University Cancer Hospital, Chongqing, Chongqing Municipality Fujian Medical University Union Hospital, Fuzhou Fujian, Fujian The First Affiliated hospital of Xiamen University, Xiamen, Fujian The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Cancer Hospital of Shantou University Medical College, Shantou, Guangdong Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center, Shenzhen, Guangdong
Colombia
Clinica Somer, Rionegro, Antioquia Local Institution - 0191, Puerto Colombia, Atlántico Local Institution - 0189, Bogotá, Bogota D.C. Sociedad De Oncología y Hematología Del Cesar SAS, Valledupar, Cesar Department Instituto Médico de Alta Tecnología S.A.S - IMAT S.A.S, Montería, COR Local Institution - 0671, Bogota, Cundinamarca Fundación Cardiovascular de Colombia, Floridablanca, Santander Department Fundación Valle del Lili, Cali, Valle del Cauca Department Clinica Medellin S.A, Medellín Croatia
Opća bolnica Dubrovnik, Dubrovnik, Dubrovnik-Neretva County Poliklinika MEDICO - Rijeka, Rijeka, Primorje-Gorski Kotar County Klinički Bolnički Centar Split, Split, Split-Dalmatia County Local Institution - 0567, Osijek Local Institution - 0585, Zagreb France
Local Institution - 0159, Mulhouse, Alsace Centre François Baclesse, Caen, Calvados Centre Georges François Leclerc, Dijon, Côte-d'Or CHRU de Brest, Brest, Finistère Institut Régional du Cancer Montpellier, Montpellier, Hérault Chu Grenoble Alpes, La Tronche, Isère Centre Hospitalier Universitaire d'Angers, Angers, Maine-et-Loire Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandœuvre-lès-Nancy, Meurthe-et-Moselle Institut Paoli-Calmettes, Marseille, Provence-Alpes-Côte d'Azur Region CHU d'Amiens-Picardie - Hôpital Sud, Amiens, Somme Gustave Roussy, Villejuif, Val-de-Marne Hôpital Ambroise Paré, Boulogne-Billancourt Chu Gabriel Montpied, Clermont-Ferrand
Germany
Klinikum Esslingen, Esslingen am Neckar, Baden-Wurttemberg Bundeswehrkrankenhaus Ulm, Ulm, Baden-Wurttemberg Klinikum der Ludwig-Maximilians-Universitaet Muenchen, München, Bavaria Centrum für Hämatologie und Onkologie Bethanien, Frankfurt am Main, Hesse UKGM Gießen/Marburg, Giessen, Hesse Praxis Onkologie am Raschplatz, Hanover, Lower Saxony Pius Hospital Oldenburg, Oldenburg, Lower Saxony Klinikum Köln-Merheim, Cologne, North Rhine-Westphalia Evangelisches Krankenhaus Herne - Eickel, Herne, North Rhine-Westphalia Universitätsklinikum Halle, Halle, Saxony-Anhalt Malteser Krankenhaus St. Franziskus-Hospital, Flensburg, Schleswig-Holstein SRH Wald-Klinikum Gera GmbH, Gera, Thuringia Universitätsklinikum Jena, Jena, Thuringia Greece
Errikos Dunant Hospital Center, Athens, Attikí Thoracic General Hospital of Athens "I Sotiria", Athens, Attikí University General Hospital of Larissa, Larissa, Thessalía Hong Kong
Queen Mary Hospital, Hksar Queen Mary Hospital, Hksar Hungary
Local Institution - 0144, Gyöngyös - Mátraháza, Heves County Local Institution - 0157, Tatabánya, Komárom-Esztergom Farkasgyepui Tudogyogyintezet, Farkasgyepű, Veszprém megye Semmelweis Egyetem, Budapest Országos Korányi Pulmonológiai Intézet, Budapest Petz Aladar Egyetemi Oktato Korhaz, Győr India
Local Institution - 0222, Visakhapatnam, Andhra Pradesh Local Institution - 0136, Ahmedabad, Gujarat Local Institution - 0230, Ahmedabad, Gujarat Local Institution - 0155, Thiruvananthapuram, Kerala Local Institution - 0154, Mumbai, Maharashtra Local Institution - 0312, New Delhi, National Capital Territory of Delhi Local Institution - 0511, New Delhi, National Capital Territory of Delhi Local Institution - 0135, New Delhi, National Capital Territory of Delhi Local Institution - 0226, Bhubaneswar, Odisha Local Institution - 0224, Madurai, Tamil Nadu Local Institution - 0663, Hyderabad, Telangana Local Institution - 0153, Varanasi, Uttar Pradesh Local Institution - 0161, Howrah, West Bengal
Ireland
Cork University Hospital, Cork Mater Private Hospital - Dublin, Dublin St. James's Hospital, Dublin UCD School of Medicine Beacon Hospital, Dublin Beaumont Hospital, Dublin, Dublin Israel
Rabin Medical Center, Petah Tikva, Central District Sheba Medical Center, Ramat Gan, Central District Yitzhak Shamir Medical Center, Ẕerifin, Central District Hadassah Medical Center, Jerusalem, Jerusalem Carmel Hospital, Haifa, Ḥeifā Italy
Instituto Tumori Giovanni Paolo II, Bari, Apulia IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Emilia-Romagna A.O.R.N. Ospedale dei Colli - Monaldi V., Naples, Napoli Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano, Piedmont Istituto Nazionale Tumori Regina Elena, Rome, Roma Azienda Ospedaliera Universitaria Careggi, Florence, Tuscany Ospedale San Martino, Genova Istituto Oncologico Veneto IRCCS, Padova Azienda Ospedaliero Universitaria di Parma, Parma Fondazione IRCCS Policlinico San Matteo, Pavia Local Institution - 0556, Varese Japan
Local Institution - 0607, Nagoya, Aichi-ken Local Institution - 0305, Nagoya, Aichi-ken Hokkaido University Hospital, Sapporo, Hokkaido Local Institution - 0304, Kanazawa, Ishikawa-ken Local Institution - 0302, Sagamihara, Kanagawa Local Institution - 0369, Yokohama, Kanagawa Sendai Kousei Hospital, Sendai, Miyagi Local Institution - 0306, Kashihara, Nara Local Institution - 0368, Kurashiki, Okayama-ken Local Institution - 0642, Hirakata, Osaka Saitama Medical University International Medical Center, Hidaka, Saitama Local Institution - 0300, Ina-machi, Saitama Hamamatsu University Hospital, Hamamatsu, Shizuoka Mexico
Centro de Infusion E Investigacion Oncologia de Saltillo S.C., Saltillo, Coahuila Local Institution - 0176, Mexico City, DIF Local Institution - 0579, Pachuca, Hidalgo Hospital Civil Fray Antonio Alcalde, Guadalajara, Jalisco Axis Heilsa S. de R.L. de C.V., Monterrey, Nuevo León Local Institution - 0175, Chihuahua City Unidad Médica Onco-hematológica, Puebla City Local Institution - 0638, Puebla City Local Institution - 0180, Veracruz Netherlands
Maastricht UMC+, Maastricht, Limburg Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL), Amsterdam, North Holland Poland
Med-Polonia Sp. z o. o., Poznan, Greater Poland Voivodeship Szpital Specjalistyczny im. Henryka Klimontowicza, Gorlice, Lesser Poland Voivodeship Pratia MCM Krakow, Krakow, Lesser Poland Voivodeship Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii, Wroclaw, Lower Silesian Voivodeship Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie, Lublin, Lublin Voivodeship Centrum Onkologii im. Prof. Franciszka Lukaszczyka, Bydgoszcz Pratia Onkologia Katowice, Katowice Szpital Specjalistyczny w Prabutach Spolka z o.o., Prabuty Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Lisbon District Instituto Portugês de Oncologia de Coimbra Francisco Gentil, Coimbra Centro Hospitalar do Porto - Hospital de Santo António, Porto Romania
SC Memorial Healthcare International SRL, Bucharest, Bucharest Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu", Bucharest, Bucharest Cardiomed SRL Cluj-Napoca, Cluj-Napoca, Cluj SC Radiotherapy Center Cluj SRL, Florești, Cluj Ovidius Clinical Hospital OCH, Ovidiu, Constanța County Centrul de Oncologie "Sfântul Nectarie", Craiova, Dolj Cabinet Medical Oncomed, Timișoara, Timiș County Institutul Oncologic Cluj, Cluj-Napoca Institutul Oncologic Cluj, Cluj-Napoca Affidea Constanța, Constanța S.C. Centrul de Oncologie Euroclinic S.R.L., Iași Institutul Regional de Oncologie, Iași Spitalul Municipal Schuller Ploiești, Ploieşti Saudi Arabia
Local Institution - 0614, Jeddah, Makkah Al Mukarramah Local Institution - 0602, Riyadh Local Institution - 0562, Riyadh South Korea
Chungbuk National University Hospital, Cheongju-si, Chungcheongbuk-do [Chungbuk] Gachon University Gil Medical Center, Namdong-gu, Incheon-gwangyeoksi [Incheon] Pusan National University Yangsan Hospital, Yangsan, Kyǒngsangnam-do Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [Seoul] Konkuk University Medical Center, Seoul, Seoul-teukbyeolsi [Seoul] Local Institution - 0248, Seoul, Seoul-teukbyeolsi [Seoul] Korea University Guro Hospital, Seoul, Seoul-teukbyeolsi [Seoul] Spain
CHUAC-Hospital Teresa Herrera, A Coruña, A Coruña [La Coruña] CHUS - Hospital Clinico Universitario, Santiago de Compostela, A Coruña [La Coruña] Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona] Local Institution - 0497, Hospitalet, Barcelona [Barcelona] Local Institution - 0505, Barcelona, Catalunya [Cataluña] Hospital Son Llàtzer, Palma, Illes Balears [Islas Baleares] Hospital General Universitario Gregorio Marañon, Madrid, Madrid, Comunidad de Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad de Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad de Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad de CHUVI- Hospital Alvaro Cunqueiro, Pontevedra, Pontevedra [Pontevedra] Hospital Arnau de Vilanova, Valencia, València
Switzerland
Kantonsspital Münsterlingen - Spital Thurgau AG, Münsterlingen Taiwan
Chi Mei Hospital - Liouying Branch, Tainan, Tainan Tri-Service General Hospital, Taipei City, Taipei Taipei Medical University Shuang Ho Hospital, New Taipei City National Cheng Kung University Hospital, Tainan National Taiwan University Hospital, Taipei Thailand
Chulalongkorn University, Bangkok, Bangkok Faculty of Medicine - Khon Kaen University, Muang, Changwat Khon Kaen Songklanagarind hospital, Hat Yai, Changwat Songkhla Turkey (Türkiye)
Local Institution - 0199, Izmir, Karsiyaka, İzmir Local Institution - 0197, Adana Hacettepe Universite Hastaneleri, Ankara Ankara University Health Practice and Research Hospitals, Ankara Ankara Bilkent Şehir Hastanesi, Ankara Local Institution - 0550, Istanbul TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul Local Institution - 0200, Izmir United Kingdom
University College London Hospital, London, London, City of Guy's & St Thomas' NHS Foundation Trust, London, London, City of Heartlands Hospital, Birmingham Local Institution - 0545, Guildford The Royal Surrey County Hospital, Guildford Local Institution - 0093, Manchester
Key details Sponsor
Mirati Therapeutics Inc.
Enrollment target
~630 participants
Primary completion
September 2029
Age range
18 Years and older
Last updated April 2026
Interested in joining? A. C. Camargo Cancer Center, São Paulo, São Paulo
Instituto Nacional de Câncer - INCA, Rio de Janeiro Local Institution - 0258, São Paulo ShenZhen People's Hospital, Shenzhen, Guangdong
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Nanyang City Center Hospital, Nanyang, Henan The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Hubei Hunan Cancer Hospital, Changsha, Hunan Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu The First Affiliated Hospital Of Soochow University, Suzhou, Jiangsu Northern Jiangsu People's Hospital, Yangzhou, Jiangsu The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi The First Hospital of Jilin University, Changchun, Jilin The First Hospital of China Medical University, Shenyang, Liaoning Shengjing Hospital of China Medical University, Shenyang, Liaoning Liaoning Cancer Hospital, Shenyang, Liaoning Shandong Cancer Hospital, Jinan, Shandong LinYi Cancer Hospital, Linyi, Shandong Local Institution - 0470, Shanghai, Shanghai Municipality Local Institution - 0381, Shanghai, Shanghai Municipality Shanghai East Hospital, Shanghai, Shanghai Municipality Shanxi Cancer Hospital, Taiyuan, Shanxi Sichuan Cancer hospital, Chengdu, Sichuan West China Hospital, Sichuan University, Chengdu, Sichuan Tianjin Medical University General Hospital, Tianjin, Tianjin Municipality The first Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Zhejiang Cancer Hospital, Hangzhou, Zhejiang Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren, Limoges
Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille Local Institution - 0133, Paris Hopitaux Universitaires Paris Centre-Hopital Cochin, Paris Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes, Saint-Herblain Vivantes Klinikum Neukölln, Berlin Evangelische Lungenklinik Berlin, Berlin Local Institution - 0675, Halle Lungenklinik Hemer, Hemer Klinikum Stuttgart - Katharinenhospital, Stuttgart Universitaetsklinikum Wuerzburg, Würzburg Local Institution - 0221, Kolkata, West Bengal
Local Institution - 0661, Hyderabad Local Institution - 0299, Shimotsuga, Tochigi
Local Institution - 0674, Bunkyo Ku, Tokyo Local Institution - 0343, Toyoma, Toyama Local Institution - 0542, Iwakuni, Yamaguchi Local Institution - 0307, Akashi Local Institution - 0346, Aomori Kyushu University Hospital, Fukuoka Local Institution - 0367, Fukushima Local Institution - 0308, Kumamoto Local Institution - 0687, Nagasaki Osaka City General Hospital, Osaka Osaka International Cancer Institute, Osaka Hospital Clinico San Carlos, Madrid
H.R.U Málaga - Hospital General, Málaga Hospital Universitario Virgen Del Rocio, Seville Local Institution - 0495, Valencia