This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve. — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(253 sites) United States
Clearview Cancer Institute (Crestwood), Huntsville, Alabama Clearview Cancer Institute, Huntsville, Alabama Ironwood Cancer & Research Centers, Chandler, Arizona Ironwood Cancer & Research Centers, Gilbert, Arizona Ironwood Cancer & Research Centers, Glendale, Arizona Ironwood Cancer & Research Centers, Goodyear, Arizona Ironwood Cancer & Research Centers, Mesa, Arizona Ironwood Cancer & Research Centers, Mesa, Arizona Ironwood Cancer & Research Centers, Phoenix, Arizona Ironwood Cancer & Research Centers, Scottsdale, Arizona Highlands Oncology Group, PA, Fayetteville, Arkansas Highlands Oncology Group, PA, Rogers, Arkansas Highlands Oncology Group, PA, Springdale, Arkansas UCLA Hematology/Oncology - Alhambra, Alhambra, California UCLA Hematology/Oncology - Atascadero, Atascadero, California Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location), Beverly Hills, California Cedars-Sinai Cancer Beverly Hills, Beverly Hills, California UCLA Hematology/Oncology - Beverly Hills, Beverly Hills, California UCLA Hematology/Oncology - Burbank, Burbank, California UCLA Hematology/Oncology - Encino, Encino, California UCLA Hematology/Oncology - Irvine, Irvine, California UCLA Hematology/Oncology - Laguna Hills, Laguna Hills, California Cedars-Sinai Cancer at Cedars-Sinai Medical Center, Los Angeles, California Ronald Reagan UCLA Medical Center - Drug Information Center, Los Angeles, California UCLA Department of Medicine - Hematology/Oncology, Los Angeles, California UCLA Hematology/Oncology, Los Angeles, California UCLA Hematology/Oncology - Marina del Rey, Marina del Rey, California UCLA Hematology/Oncology - Pasadena, Pasadena, California UCLA Hematology/Oncology - Porter Ranch, Porter Ranch, California UCLA Hematology/Oncology - San Luis Obispo, San Luis Obispo, California UCLA Hematology/Oncology - Santa Barbara, Santa Barbara, California UCLA Hematology/Oncology- Santa Monica, Santa Monica, California UCLA Hematology/Oncology - Torrance, Torrance, California UCLA Hematology/Oncology - Santa Clarita, Valencia, California UCLA Hematology/Oncology - Ventura, Ventura, California UCLA Hematology/Oncology - Westlake, Westlake Village, California AdventHealth Medical Group Urology of Denver, Denver, Colorado Cancer Care Specialists of Illinois, Decatur, Illinois Cancer Care Specialists of Illinois, O'Fallon, Illinois University of Rochester Medical Center, Rochester, New York University of Rochester, Cancer Center Pharmacy (Investigational Product), Rochester, New York Montefiore Einstein Comprehensive Cancer Center, The Bronx, New York Montefiore Medical Center- Montefiore Medical Park, The Bronx, New York Duke Cancer Center Cary, Cary, North Carolina Duke University Medical Center (location of scans), Durham, North Carolina Duke University Medical Center - Duke Cancer Center, Durham, North Carolina Duke University Medical Center - Duke University Hospital (location of scans), Durham, North Carolina Duke University, Durham, North Carolina Duke Cancer Center Raleigh, Raleigh, North Carolina Duke Raleigh Hospital, Raleigh, North Carolina Duke Women's Cancer Care Raleigh (Pharmacy location and location of CT, MRI and Bone scan machines), Raleigh, North Carolina University Hospitals Seidman Cancer Center at UH Avon Health Center, Avon, Ohio TriState Urologic Services PSC Inc. dba The Urology Group, Cincinnati, Ohio University Hospitals Cleveland Medical Center, Cleveland, Ohio University Hospitals Seidman Cancer Center at UH Mentor Health Center, Mentor, Ohio UH Minoff Health Center at Chagrin Highlands, Orange, Ohio The Centers for Advanced Urology, LLP d/b/a Keystone Urology Specialists, Lancaster, Pennsylvania Grand Strand Medical Center, Myrtle Beach, South Carolina Carolina Urologic Research Center, LLC, Myrtle Beach, South Carolina Parkway Surgery Center, Myrtle Beach, South Carolina The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee Urology Associates, P.C., Nashville, Tennessee University of Texas Southwestern Medical Center - Simmons Cancer Center, Dallas, Texas University of Texas Southwestern Medical Center - William P. Clements, Jr., University Hospital, Dallas, Texas University of Texas Southwestern Simmons Cancer Center - Redbird, Dallas, Texas University of Texas Southwestern Medical Center-Zale Lipshy University Hospital, Dallas, Texas University of Texas Southwestern Medical Center, Dallas, Texas University of Texas Southwestern Simmons Cancer Center - Fort Worth, Fort Worth, Texas US Oncology Investigational Product Center (IPC), Irving, Texas University of Texas Southwestern Simmons Cancer Center - Richardson/Plano, Richardson, Texas Huntsman Cancer Institute, Salt Lake City, Utah Blue Ridge Cancer Care, Blacksburg, Virginia Blue Ridge Cancer Care, Low Moor, Virginia Blue Ridge Cancer Care, Roanoke, Virginia Blue Ridge Cancer Care, Salem, Virginia Blue Ridge Cancer Care, Wytheville, Virginia Northwest Medical Specialties, PLLC, Bonney Lake, Washington Northwest Medical Specialties, PLLC, Federal Way, Washington Northwest Medical Specialties, PLLC, Gig Harbor, Washington Northwest Medical Specialties, PLLC, Puyallup, Washington Northwest Medical Specialties, PLLC, Tacoma, Washington University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin Argentina
Asociación de Beneficencia Hospital Sirio Libanés, Ciudad Autonoma de Buenos Aires, Buenos Aires Sanatorio Británico, Rosario, Santa Fe Province Instituto de Oncología de Rosario, Rosario, Santa Fe Province Centro Oncologico Korben, Buenos Aires Australia
Orange Health Service, Orange, New South Wales Sydney Adventist Hospital, Wahroonga, New South Wales Icon Cancer Centre Chermside, Chermside, Queensland Mater Misericordiae Limited Mater Cancer Care Centre, South Brisbane, Queensland ICON Cancer Centre - Kurralta Park, Kurralta Park, South Australia Sir Charles Gairdner Hospital, Nedlands, Western Australia Belgium
Institut Jules Bordet, Anderlecht, Bruxelles-capitale, Région de Jessa Ziekenhuis, Hasselt, Limburg AZ Maria Middelares, Ghent, Oost-vlaanderen AZ Sint-Lucas, Ghent, Oost-vlaanderen UZ Leuven, Leuven, Vlaams-brabant AZORG Campus Aalst-Moorselbaan, Aalst Brazil
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André, São Paulo Bulgaria
MBAL Uni Hospital, Panagyurishte, Pazardzhik Medical Center Futuremeds, Plovdiv Complex Oncology Center - Plovdiv EOOD, Plovdiv Canada
Prostate Cancer Centre, Calgary, Alberta Centre of Applied Urology Research/Nova Scotia Health Authority, Halifax, Nova Scotia Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre, Greenfield Park, Quebec Centre Hospitalier de l'Université de Montréal, Montreal, Quebec Jewish General Hospital, Montreal, Quebec Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus, Québec, Quebec Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer, Sherbrooke, Quebec Diex Recherche Trois-Rivieres, Trois-Rivières, Quebec China
Wannan Medical College Yijishan Hospital, Wuhu, Anhui Peking University First Hospital, Beijing, Beijing Municipality Beijing Friendship Hospital Affiliate of Capital University, Beijing, Beijing Municipality The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing Municipality Chongqing University Cancer Hospital, Chongqing, Chongqing Municipality Lanzhou university second hospital, Lanzhou, Gansu The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei Hunan Cancer Hospital, Changsha, Hunan First Huai'an Hospital Affiliated to Nanjing Medical University, Huai'an, Jiangsu Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Czechia
Masarykuv onkologicky ustav, Brno Fakultni nemocnice Hradec Kralove, Hradec Králové Fakultni nemocnice Olomouc, Olomouc Urocentrum Praha s.r.o., Prague Fakultni Thomayerova nemocnice, Prague Fakultni nemocnice v Motole, Prague Finland
Oulun yliopistollinen sairaala, Oulu, North Ostrobothnia Kuopion Yliopistollinen Sairaala, Kuopio, Northern Savonia Tampereen yliopistollinen sairaala, Tampere, Pirkanmaa Vaasan Keskussairaala, Vaasa, Pohjanmaa Turku University Hospital, Turku, Southwest Finland Docrates Syöpäsairaala, Helsinki, Uusimaa France
Centre Antoine-Lacassagne, Nice, Alpes-maritimes Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux, Aquitaine Centre Leon Berard, Lyon Cedex08, Auvergne-Rhône-Alpes Groupe Vivalto Santé - Clinique Pasteur-Lanroze, Brest, Brittany Region CHU Besançon, Besançon, Doubs Institut Godinot, Reims, Marne Institut Jean Godinot, Reims, Marne Centre Hospitalier de la Côte Basque, Bayonne, Pyrénées-atlantiques Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône Gustave Roussy, Villejuif, Val-de-marne Henri Mondor Hospital, Créteil, Île-de-France Region Germany
Studienpraxis Urologie, Nürtingen, Baden-Wurttemberg Universitaetsklinikum Ulm, Ulm, Baden-Wurttemberg Urologie Neandertal - Praxis Mettmann, Mettmann, North Rhine-Westphalia Universitätsklinikum Münster - Albert Schweitzer Campus, Münster, North Rhine-Westphalia Charité Universitaetsmedizin Berlin, Berlin Greece
Metropolitan Hospital, Athens Athens Medical Center S.A -European Interbalkan Medical Center, Thessaloniki Israel
Rabin Medical Center, Petah Tikva, Central District Sheba Medical Center, Ramat Gan, Central District Yitzhak Shamir Medical Center, Ẕerifin, Central District Shaare Zedek Medical Center, Jerusalem, Jerusalem Hadassah Medical Center, Jerusalem, Jerusalem Rambam Health Care Campus, Haifa, Northern District Sourasky Medical Center, Tel Aviv, TELL ABĪB Italy
IRCCS Istituto Clinico Humanitas, Rozzano, Milano Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano, Piedmont Istituto Nazionale Tumori Regina Elena, Rome, ROMA Azienda Ospedaliero Universitaria Maggiore della Carità, Novara ASUIT Trento - Santa Chiara Hospital, Trento Centro Ricerche Cliniche di Verona, Verona Japan
Chiba cancer center, Chiba, Chiba National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido Hokkaido University Hospital, Sapporo, Hokkaido Kobe University Hospital, Kobe, Hyōgo Kanazawa University Hospital, Kanazawa, Ishikawa-ken Yokohama City University Medical Center, Yokohama, Kanagawa Yokosuka Kyosai Hospital, Yokosuka, Kanagawa The University of Osaka Hospital, Suita, Osaka Keio university hospital, Shinjuku-ku, Tokyo National Hospital Organization Kyushu Cancer Center, Fukuoka National Hospital Organization Kumamoto Medical Center, Kumamoto Osaka International Cancer Institute, Osaka
Netherlands
Canisius-Wilhelmina Ziekenhuis, Nijmegen, Gelderland Tergooi MC, Hilversum, North Holland Reinier de Graaf Ziekenhuis, locatie Delft, Delft, South Holland New Zealand
Tauranga Hospital, Tauranga, Bay of Plenty Christchurch Hospital, Christchurch, Canterbury Waikato Hospital, Hamilton, Waikato Region Auckland City Hospital, Auckland Palmerston North Hospital, Palmerston North Poland
Clinical Research Center Spółka z ograniczoną odpowiedzialnością MEDIC-R Sp.k, Poznan, Greater Poland Voivodeship Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie, Krakow, Lesser Poland Voivodeship POLIMED CLINIC Sp. z o.o., Wroclaw, Lower Silesian Voivodeship Zachodniopomorskie Centrum Onkologii, Szczecin, West Pomeranian Voivodeship Szpitale Pomorskie Sp. z o.o., Gdynia Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie, Koszalin Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o .o., Krakow Clinical Best Solutions Sp. z o.o. S.K., Lublin Centrum Medyczne MEDYK, Rzeszów Zachodniopomorskie Centrum Onkologii, Szczecin EMC Instytut Medyczny S.A., Wroclaw Slovakia
Narodny onkologicky ustav, Bratislava Vychodoslovensky onkologicky ustav, a.s., Košice MILAB, s.r.o., Urologicka ambulancia, Prešov Privatna urologicka ambulancia, s.r.o., Trenčín South Korea
Chonnam National University Hwasun Hospital, Hwasun-gun, Jeonranamdo National Cancer Center, Goyang-si, Kyǒnggi-do Seoul National University Bundang Hospital, Seongnam, Kyǒnggi-do Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [seoul] Severance Hospital, Yonsei University Health System, Seoul, Seoul-teukbyeolsi [seoul] Asan Medical Center, Seoul, Seoul-teukbyeolsi [seoul] Samsung Medical Center, Seoul, Seoul-teukbyeolsi [seoul] Ewha Womans University Mokdong Hospital, Seoul, Seoul-teukbyeolsi [seoul] Kyungpook National University Chilgok Hospital, Deagu, Taegu-kwangyǒkshi Chungnam national university hospital, Junggu, Taejǒn-kwangyǒkshi Spain
Parc de Salut Mar - Hospital del Mar, Barcelona, Barcelona [barcelona] Althaia, Xarxa Assistencial Universitària de Manresa, Manresa, Barcelona Hospital Clínic de Barcelona, Barcelona, Catalunya [cataluña] Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad de Hospital Universitario Virgen de la Victoria, Málaga, Málaga CHUVI- Hospital Alvaro Cunqueiro, Vigo, Pontevedra [pontevedra] Fundación Instituto Valenciano de Oncología, Valencia, Valenciana, Comunitat Hospital Clinico San Carlos, Madrid Hospital General Universitario de Valencia, Valencia Switzerland
Inselspital Bern, Bern, Canton of Bern Kantonsspital Winterthur, Winterthur UniversitätsSpital Zürich, Zurich Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City Taichung Veterans General Hospital, Taichung National Cheng Kung University Hospital, Tainan National Taiwan University Hospital, Taipei Taipei Veterans General Hospital, Taipei Chang Gung Medical Foundation-Linkou Branch, Taoyuan District United Kingdom
Royal Blackburn Hospital, Blackburn, Blackburn WITH Darwen Velindre Cancer Centre, Cardiff, Cardiff [caerdydd Gb-crd] Derriford Hospital, Plymouth, Devon Torbay Hospital, Torquay, Devon Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, Hammersmith and Fulham Royal Marsden Hospital (Chelsea), London, Kensington and Chelsea Maidstone Hospital, Maidstone, KENT Guy's & St Thomas' NHS Foundation Trust, London, London, CITY of Western General Hospital, Edinburgh, Midlothian The Christie NHS Foundation Trust, Manchester Key details Enrollment target
~1,000 participants
Primary completion
September 2028
Age range
18 Years and older
Nantong Tumor Hospital, Nantong, Jiangsu The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu The First Hospital of China Medical University, Shenyang, Liangning The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Qilu Hospital of Shandong University, Jinan, Shandong Fudan University Shanghai Cancer Center, Shanghai, Shanghai Municipality Suining Central Hospital, Suining, Sichuan Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang The first affiliated hospital of Ningbo university, Ningbo, Zhejiang The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang The Third Affiliated Hospital of Southern Medical University, Guangzhou Yamagata University Hospital, Yamagata