Osteogenesis Imperfecta Trial of AGA2115 for ADUlts With COL1A1 and/or COL1A2 GeNetic Variations (IDUN)

Phase 2 — Testing in a larger group (up to a few hundred people) to further evaluate safety and begin to assess effectiveness.

Trial locations(26 sites)

United States

Phoenix Children's, Phoenix, Arizona

Yale University School of Medicine, New Haven, Connecticut

Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware

Indiana University School of Medicine, Department of Medicine and Pediatrics Division of Endocrinology, Indianapolis, Indiana

Washington University School of Medicine in St. Louis, St Louis, Missouri

University of Nebraska Medical Center (UNMC) - Diabetes and Endocrinology Center, Omaha, Nebraska

New Mexico Clinical Research & Osteoporosis Center, Inc. (NMCROC), Albuquerque, New Mexico

The Ohio State University Wexner Medical Center (OSUWMC), Columbus, Ohio

Oregon Health & Science University (OHSU) - The Harold Schnitzer Diabetes Health Center (HSDHC) - Endocrinology Clinic, Portland, Oregon

Vanderbilt University Medical Center (VUMC) - Eskind Diabetes Clinic, Nashville, Tennessee

Argentina

Instituto de Investigaciones Metabolicas Dr. Zanchetta - Sede Centro, Buenos Aires

Australia

Monash University-Monash Medical Centre (MMC), Melbourne

Royal Melbourne Hospital, Parkville

Royal North Shore Hospital (RNSH), Saint Leonards

Adults Westmead Hospital, Westmead

Canada

University Health Network - Toronto General Hospital - Osteoporosis Clinic, Toronto, Ontario

Denmark

Aarhus Universitetshospital - Medicinsk Endokrinologisk Afdeling (MEA) Ambulatoriet - Tage-Hansens Gade, Aarhus

Odense Universitetshospital, Odense

France

Hopital Edouard Herriot, Lyon

Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Lariboisiere, Paris

Netherlands

Leiden University Medical Center (LUMC) - Centrum voor botkwaliteit, Leiden

Erasmus MC, Rotterdam

Isala ziekenhuizen, Zwolle

United Kingdom

Cambridge University Hospitals NHS Foundation Trust-Addenbrooke's Hospital, Cambridge

Lothian Health Board, Western General Hospital, Edinburgh

Royal National Orthopaedic Hospital NHS Trust, London