Beamion LUNG-3: A Study to Test Whether Zongertinib Helps People With Surgically Removed, Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(196 sites) United States
ClinRé 001-022 (Premier Cancer Care and Infusion Center), Fresno, California OPN Healthcare, Inc., Glendale, California University of California Irvine, Irvine, California Sutter Health, Roseville, California University of California San Francisco, San Francisco, California Sarcoma Oncology Center, Santa Monica, California University of California Los Angeles, Santa Monica, California Northern California Kaiser Permanente, Vallejo, California George Washington University Cancer Center, Washington D.C., District of Columbia Mid Florida Hematology and Oncology Center, Orange City, Florida Piedmont Cancer Institute, Atlanta, Georgia Northwest Georgia Oncology Centers, Marietta, Georgia Saint Alphonsus Regional Medical Center - Boise, Boise, Idaho Northwestern University, Chicago, Illinois University of Illinois Hospital and Health Sciences System, Chicago, Illinois Duly Health and Care - Lisle, Lisle, Illinois Dana-Farber Cancer Institute, Boston, Massachusetts Cancer Care Specialists, Reno, Nevada Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York Memorial Sloan-Kettering Cancer Center, New York, New York Levine Cancer Institute, Charlotte, North Carolina Providence Cancer Institute, Portland, Oregon Hendrick Health, Abilene, Texas Community Cancer Trials of Utah, Ogden, Utah Virginia Cancer Specialists, PC, Fairfax, Virginia Argentina
Centro de Investigaciones Médicas y Desarrollo LC S.R.L. (LC Investigación), CABA Hospital Britanico de Buenos Aires, CABA Centro Oncologico Korben, CABA Clinica Adventista Belgrano, CABA Instituto Medico Especializado Alexander Fleming, Capital Federal Instituto de Investigaciones Clinicas Mar del Plata, Mar del Plata Australia
Royal North Shore Hospital, Sydney, New South Wales Princess Alexandra Hospital, Woolloongabba, Queensland Flinders Medical Centre, Bedford Park, South Australia Austin Health, Heidelberg, Victoria St John of God Subiaco Hospital, Subiaco, Western Australia Austria
Medical University of Innsbruck, Innsbruck Clinic Floridsdorf, Vienna Belgium
Edegem - UNIV UZ Antwerpen, Edegem Centre Hospitalier Universitaire de Liège, Liège Brazil
Hospital de Amor, Barretos NewData Clinical Research - Maceió, Maceió Centro de Pesquisa Oncology Natal, Natal Centro Gaúcho Integrado de Oncologia, Hematologia, Ensino e Pesquisa, Porto Alegre CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia, Santo André ICESP - Instituto do Cancer do Estado de Sao Paulo, São Paulo Canada
Cross Cancer Institute (University of Alberta), Edmonton, Alberta Princess Margaret Cancer Centre, Toronto, Ontario Chile
Centro de Estudios Clinicos SAGA, Providencia Bradford Hill- Centro de Investigación Clínica, Recoleta China
China-Japan Friendship Hospital, Beijing Beijing Chest Hospital, Capital Medical University, Beijing The First Hospital of Jilin University, Changchun Xiangya Hospital, Central South University, Changsha Hunan Province Tumor Hospital, Changsha Sichuan Cancer Hospital, Chengdu West China Hospital, Sichuan University, Chengdu The First Affiliated Hospital,Sun Yat-sen University, Guangzhou The First Affiliated Hospital, Zhejiang University, Hangzhou Zhejiang Cancer Hospital, Hangzhou Harbin Medical University Cancer Hospital, Harbin Shandong Cancer Hospital, Jinan Yunnan Provincial Tumor Hospital, Kunming Denmark
Sjællands Universitetshospital, Roskilde France
Hôpital Louis Pradel, Bron HOP Tenon - One AP-HP, Paris Centre Régional de Lutte Contre le Cancer Paul Stauss, Strasbourg Hôpital Larrey - CHU de Toulouse, Toulouse Institut Gustave Roussy, Villejuif Germany
Universitätsklinikum Köln (AöR), Cologne Klinikum Esslingen, Esslingen am Neckar Varisano LungenZentrum (VLZ), Frankfurt Asklepios Fachkliniken München-Gauting, Gauting LungenClinic Grosshansdorf GmbH, Großhansdorf Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg, Heidelberg Pius-Hospital, Oldenburg, Oldenburg Universitätsklinikum Würzburg AÖR, Würzburg Greece
Henry Dunant Hospital, Athens, Athens Chest Hospital of Athens "Sotiria", Athens University General Hospital Attikon, Athens Hong Kong
Queen Elizabeth Hospital-Hong Kong-51727, Hong Kong Prince of Wales Hospital-Hong Kong-20715, Hong Kong Princess Margaret Hospital, Hong Kong Queen Mary Hospital, Hong Kong Israel
Rambam Health Care Campus, Haifa Shaare Zedek Medical Center, Jerusalem 91031, Jerusalem Meir Medical Center, Kfar Saba Sheba Medical Center, Ramat Gan Sourasky Medical Center, Tel Aviv Italy
Istituto Tumori Giovanni Paolo II, Bari Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Humanitas Istituto Clinico Catanese S.p.A., Misterbianco (CT) Istituto Nazionale IRCCS Tumori Fondazione Pascale, Naples AOU San Luigi Gonzaga, Orbassano (TO) Istituti Fisioterapici Ospitalieri, Roma Istituto Clinico Humanitas, Rozzano (MI) Azienda Ospedaliera Universitaria Integrata Verona, Verona Japan
Aichi Cancer Center Hospital, Aichi, Nagoya Fujita Health University Hospital, Aichi, Toyoake National Cancer Center Hospital East, Chiba, Kashiwa Kyushu University Hospital, Fukuoka, Fukuoka Hospital of the University of Occupational and Environmental Health, Fukuoka, Kitakyushu Hiroshima University Hospital, Hiroshima, Hiroshima Hokkaido Cancer Center, Hokkaido, Sapporo Kitasato University Hospital, Kanagawa, Sagamihara Kanagawa Cancer Center, Kanagawa, Yokohama Sendai Kousei Hospital, Miyagi, Sendai Niigata Cancer Center Hospital, Niigata, Niigata Okayama University Hospital, Okayama, Okayama Kansai Medical University Hospital, Osaka, Hirakata
Mexico
Centro Oncologico Internacional, Jalisco Centro de Infusion Profesional Integral (CIPI), Mexico City Centro Oncologico Personalizado, México Instituto Nacional de Cancerologia, México Centro Medico Zambrano Hellion, Monterrey Netherlands
Nederlands Kanker Instituut - Antoni van Leeuwenhoek Amsterdam (METC AVL), Amsterdam Portugal
Hospital CUF Tejo, Lisbon Hospital CUF Porto, Porto IPO Porto Francisco Gentil, EPE, Porto Romania
Memorial Healthcare International, Bucharest Ovidius Clinical Hospital S.R.L, Ovidiu Polaris Medical S.A., Suceagu/ Cluj Napoca Singapore
National Cancer Centre Singapore, Singapore South Korea
National Cancer Center, Goyang Seoul National University Bundang Hospital, Seongnam Seoul National University Hospital, Seoul Severance Hospital, Seoul Asan Medical Center, Seoul Samsung Medical Center, Seoul The Catholic University of Korea, St.Vincent's Hospital, Suwon Ajou University Hospital, Suwon Spain
Hospital del Mar, Barcelona Hospital Universitari Vall D Hebron, Barcelona Hospital Universitario De Burgos, Burgos Hospital General Universitario de Elche, Elche Hospital Jerez de la Frontera, Jerez de la Frontera Hospital Duran i Reynals, L'Hospitalet de Llobregat Hospital Universitario Ramon Y Cajal, Madrid Fundación Jiménez Díaz, Madrid Hospital Universitario 12 de Octubre, Madrid Hospital Puerta de Hierro, Majadahonda Hospital Universitario Virgen de la Victoria, Málaga Complejo Hospitalario de Navarra, Pamplona Salut Sant Joan de Reus, Reus Sweden
Sahlgrenska Universitetsjukhuset, Gothenburg Karolinska Universitetssjukhuset Solna, Stockholm Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City China Medical University Hospital, Taichung National Taiwan University Hospital, Taipei Taipei Veterans General Hospital, Taipei Tri-Service General Hospital, Taipei Chang Gung Memorial Hospital, Linkou, Taoyuan Turkey (Türkiye)
Sağlık Bilimleri Üniversitesi Gülhane Eğitim ve Araştırma Hastanesi, Ankara Medeniyet University, Istanbul United Kingdom
Velindre Cancer Centre, Cardiff Western General Hospital, Edinburgh The Royal Marsden Hospital, Chelsea, London The Royal Marsden Hospital, Sutton, Sutton Key details Sponsor
Boehringer Ingelheim
Enrollment target
~400 participants
Primary completion
February 2032
Age range
18 Years and older
Last updated April 2026
Interested in joining? Linyi Cancer Hospital, Linyi
The First Affiliated Hospital of Nanchang University, Nanchang Nanjing Drum Tower Hospital, Nanjing Ningbo Second Hospital, Ningbo Shanghai East Hospital, Shanghai Shanghai Pulmonary Hospital, Shanghai The First Affiliated Hospital of Soochow University, Suzhou Taizhou Hospital of Zhejiang Province, Taizhou Tianjin Cancer Hospital, Tianjin Tianjin Medical University General Hospital, Tianjin Wuhan Union Hospital, Wuhan Affiliated Hospital, Xuzhou Medical college, Xuzhou Northern Jiangsu People's Hospital, Yangzhou Henan Cancer Hospital, Zhengzhou Osaka International Cancer Institute, Osaka, Osaka
Kindai University Hospital, Osaka, Sakai National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Sakai Saitama Medical University International Medical Center, Saitama, Hidaka Saitama Cancer Center, Saitama, Kitaadachi-gun Shizuoka Cancer Center, Shizuoka, Sunto-gun Jichi Medical University Hospital, Tochigi, Shimotsuke Juntendo University Hospital, Tokyo, Bunkyo-ku National Cancer Center Hospital, Tokyo, Chuo-ku Japanese Foundation for Cancer Research, Tokyo, Koto-ku Tokyo Medical University Hospital, Tokyo, Shinjuku-ku Wakayama Medical University Hospital, Wakayama, Wakayama Hospital Virgen del Rocío, Seville
Hospital Clinico Universitario de Valencia, Valencia