Finding the Right Anesthesia Doses for Surgery Comfort
What is this trial?
This completed trial tested two anesthetic medications—ciprofol and remifentanil—used together during surgery to figure out the best doses that would keep patients comfortable and prevent pain during the breathing tube insertion. Researchers used a special monitoring tool called the qNOX index to measure how well the anesthesia was working throughout the process.
When doctors place a breathing tube during surgery, it can trigger a painful response in patients even under anesthesia. This trial was designed to find the precise doses of two medications that work together most effectively to prevent that discomfort while keeping patients safe.
What participation looks like
Participants underwent elective surgery under general anesthesia as planned, but received the study medications (ciprofol and remifentanil) in carefully controlled doses delivered through IV infusion. The trial was conducted in two stages: in the first stage, researchers fixed the ciprofol dose and measured how much remifentanil was needed; in the second stage, they fixed the remifentanil dose and measured ciprofol needs. Throughout the procedure, the qNOX monitoring tool tracked how well the anesthesia was preventing pain responses to the breathing tube insertion.
AI-generated summary from trial data · Apr 17, 2026 · Not medical advice
Trial locations(1 site)
China