Anorexia nervosa has the highest mortality rate of any psychiatric condition and remains one of the most treatment-resistant. It is characterized by severe food restriction, distorted body image, and intense fear of weight gain, and affects patients across all demographics though most commonly adolescent and young adult women.
What's actually going on in research
Deep brain stimulation targeting reward and interoceptive circuits is in trials for severe, treatment-resistant anorexia. Psilocybin-assisted therapy is in early trials based on evidence it may reduce rigidity and increase psychological flexibility in anorexia. Olanzapine reduces anxiety around eating and is being tested more rigorously alongside intensive outpatient and inpatient programs.
Deep brain stimulation
Targeting the subcallosal cingulate cortex or nucleus accumbens with electrical stimulation is in trials for adults with severe, long-duration treatment-resistant anorexia.
Psilocybin-assisted therapy
Psilocybin combined with structured psychotherapy is in early trials for anorexia, aiming to disrupt rigid cognitive patterns and increase openness to weight restoration.
Olanzapine in anorexia
Olanzapine reduces weight-related anxiety and is being tested in controlled trials as an add-on to improve weight restoration outcomes in both inpatient and outpatient settings.
What to know before you search
Eligibility requires a confirmed anorexia nervosa diagnosis, specified BMI threshold and medical stability, age, and often prior treatment failure for neuromodulation trials.
What types of trials are currently open
- Drug trials — Testing olanzapine, D-cycloserine, and novel agents to reduce anxiety and support weight restoration.
- Psychotherapy trials — Comparing CBT, family-based treatment, and acceptance-based therapies across ages and settings.
- Neuromodulation trials — Testing deep brain stimulation, TMS, and other brain stimulation approaches for treatment-resistant anorexia.
- Psychedelic-assisted therapy trials — Evaluating psilocybin and ketamine in structured therapeutic settings for anorexia.
- Inpatient and residential trials — Comparing treatment models, refeeding schedules, and transition-of-care strategies.
Recently added Anorexia Nervosa trials
Cognitive Evaluation of Patients With Eating Disorders
The goal of this cross - sectional observational study is to improve understanding of the psychological and cognitive characteristics of Feeding and Eating Disorders (FEDs), a group of conditions that represent a growing public health concern due to their significant impact on physical health, emotional well-being, and everyday functioning. Within this broader diagnostic category, particular attention is given to Avoidant/Restrictive Food Intake Disorder (ARFID), a diagnosis introduced in the DSM-5 and still relatively underexplored compared to other feeding and eating disorders. Despite its clinical relevance, ARFID remains less well understood in terms of its underlying cognitive and psychological mechanisms. Individuals with ARFID often experience severe food avoidance or restriction that is not driven by weight or shape concerns, but rather by sensory sensitivities, fear of negative consequences of eating, or a lack of interest in food. For this reason, investigating ARFID can offer important insights into the diversity of mechanisms involved in feeding and eating disorders as a whole. The study has two main objectives. The first objective is to examine the cognitive profile of individuals with ARFID, with a specific focus on autistic traits and cognitive flexibility, as previous research suggests potential overlaps between ARFID and neurodevelopmental conditions such as Autism Spectrum Disorders. Cognitive flexibility refers to the ability to adapt thoughts and behaviors in response to changing situations, and reduced flexibility may contribute to rigid eating patterns and food avoidance. The second objective is to explore the role of body representation (how individuals perceive and mentally represent their own body) and inhibitory control (the ability to regulate or suppress automatic responses) in shaping the cognitive and behavioral features of ARFID and other feeding and eating disorders. These processes may help distinguish ARFID from other diagnoses and clarify shared and disorder-specific mechanisms across the FED spectrum. The study involves adult participants of all genders, including individuals diagnosed with ARFID, anorexia nervosa, and bulimia nervosa, as well as healthy control participants without a history of feeding or eating disorders. This design allows meaningful comparisons between different diagnostic groups and with the general population. The main questions the study aims to answer are: Do individuals with ARFID show a distinct cognitive profile, particularly in terms of autistic traits and cognitive flexibility, compared to individuals with other feeding and eating disorders and healthy controls? How do body representation and inhibitory control contribute to differences in eating-related behaviors across feeding and eating disorders? Are there differences in brain activity associated with implicit, automatic attitudes toward food in individuals with feeding and eating disorders compared to healthy individuals? Where comparison groups are included, researchers will compare participants with ARFID, anorexia nervosa, bulimia nervosa, and healthy controls to examine differences in cognitive functioning, psychological characteristics, and neural responses related to food processing. Participants will be asked to take part in a series of non-invasive and well-established research activities, designed to be accessible and safe. These include: Completing self-report questionnaires assessing autistic traits, body image perception, and general psychological well-being; Performing computer-based tasks that assess cognitive flexibility and decision-making; Completing behavioral tasks designed to measure inhibitory control and automatic associations with food-related stimuli;
Feasibility and Acceptability of Metacognitive Training for Eating Disorders in Adolescents With Anorexia Nervosa
This study aims to assess the feasibility and acceptability of Metacognitive Training for Eating Disorders (MCT-ED) in adolescents with anorexia nervosa and atypical anorexia nervosa.
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