Cataracts are clouding of the eye's lens that develops with age in most people over 60. Surgery to replace the clouded lens with an artificial one is safe, common, and restores vision for millions each year. Research is exploring ways to prevent cataracts or dissolve them without surgery.
What's actually going on in research
Most trials focus on surgical techniques — comparing lens types, laser-assisted surgery, and methods to reduce complications. Some studies test eye drops containing lanosterol or other compounds that might dissolve cataracts. Others examine whether supplements, UV protection, or managing diabetes can slow cataract formation.
Premium lens implants
New artificial lenses can correct astigmatism or allow both near and distance vision without glasses. Trials compare these multifocal and extended-depth lenses to standard implants.
Non-surgical treatments
Researchers are testing eye drops containing lanosterol and similar molecules that may dissolve lens proteins and clear cataracts. Early studies show promise in animals, with human trials now underway.
What to know before you search
Eligibility typically depends on cataract severity, whether you've had prior eye surgery, and presence of other eye conditions like glaucoma or macular degeneration.
What types of trials are currently open
- Surgical technique trials — Comparing laser-assisted cataract surgery to standard methods, or testing new ways to position and secure lens implants.
- Lens implant trials — Testing new artificial lenses that correct multiple vision problems at once or reduce glare and halos at night.
- Prevention trials — Testing whether vitamins, antioxidants, or UV-blocking glasses can slow cataract development in people at risk.
- Eye drop trials — Testing drops containing lanosterol or other compounds that aim to dissolve cataracts without surgery.
- Complication studies — Following people after cataract surgery to understand what causes clouding of the lens capsule or other late problems.
Recently added Cataracts trials
A Multi Center Evaluation of TearCare on Surgical Measurements Before Cataract Surgery
The goal of this study is to evaluate whether TearCare treatment stabilizes corneal measurements sufficiently to determine when cataract biometry can be considered reliable.
Rotational Stability of the Acunex Vario Toric
Efficacy of the rotational stability and astigmatism correction of a toric EDOF IOL, the Acunex Vario toric.
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