Concussion is a mild traumatic brain injury that temporarily disrupts normal brain function. Most people recover within days to weeks, but some experience symptoms that last months or longer. Treatment focuses on rest, gradual return to activity, and managing specific symptoms like headache or sleep problems.
What's actually going on in research
Trials are testing medications to speed recovery and reduce persistent symptoms, studying blood tests and imaging that might predict who will have prolonged symptoms, and exploring therapies for post-concussion syndrome. Researchers are also studying repeated concussions in athletes and military personnel to understand long-term brain effects.
Biomarkers and imaging
Blood tests measuring brain proteins and advanced MRI techniques are being studied to diagnose concussion objectively and predict recovery time. These tools could replace reliance on self-reported symptoms alone.
Post-concussion treatments
Trials are testing drugs that target brain inflammation, nerve repair, and neurotransmitter imbalances in people whose symptoms persist beyond three months. Approaches include repurposed medications and behavioral therapies.
Prevention strategies
Studies are testing protective equipment modifications, rule changes in sports, and training programs that might reduce concussion risk. Other research examines whether certain interventions immediately after injury can prevent prolonged symptoms.
What to know before you search
Eligibility often depends on time since injury, symptom severity, whether this is a first or repeated concussion, and age.
What types of trials are currently open
- Treatment trials — Testing medications or supplements to speed recovery or reduce symptom severity in the first weeks after concussion.
- Post-concussion syndrome trials — Testing treatments for people whose symptoms persist beyond three months, including drugs, cognitive therapy, and vestibular rehabilitation.
- Biomarker studies — Collecting blood samples and brain scans to identify markers that can diagnose concussion or predict who will have prolonged recovery.
- Rehabilitation trials — Testing exercise protocols, cognitive training, and physical therapy approaches to help people return to work, school, and sports safely.
- Long-term outcome studies — Following people with single or multiple concussions over years to understand risks of depression, dementia, and other brain conditions.
Recently added Concussion trials
Repurposing Insulin With Intranasal Administration to Improve Function After Mild Traumatic Brain Injury
This Phase II clinical trial protocol will provide evidence as to whether IN insulin is efficacious in reducing symptoms in people seeking care for mild TBI (concussion).
Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)
The primary goal of this study is to evaluate the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI. Specifically, the study will: Evaluate PTSD Symptom Reduction - PTSD symptoms, specifically hyperarousal and hypervigilance will be assessed using the Davidson Trauma Scale, which will provide insight into improvements PTSD symptom reduction.
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