Deep vein thrombosis (DVT) is a blood clot that forms in a deep vein, usually in the leg. It affects about 1 in 1,000 people annually and can lead to pulmonary embolism if the clot breaks loose. Treatment has long relied on anticoagulants, and newer oral options have made long-term management easier than the warfarin era.
What's actually going on in research
Trials are testing direct oral anticoagulants (DOACs) like rivaroxaban and apixaban in different dosing strategies, extended treatment durations to prevent recurrence, and catheter-based clot removal for severe cases. Research also focuses on identifying who needs long-term anticoagulation and who can safely stop after a few months.
Extended anticoagulation strategies
Studies are comparing shorter versus longer courses of blood thinners to see who benefits from extended treatment. The goal is to prevent recurrent clots without increasing bleeding risk unnecessarily.
Catheter-directed thrombolysis
For severe DVT, trials are testing whether breaking up the clot with a catheter prevents long-term leg damage. Early results suggest it may reduce post-thrombotic syndrome in select patients.
Risk stratification tools
Researchers are developing tests to predict who will have recurrent DVT after stopping anticoagulation. D-dimer levels and ultrasound findings may help personalize treatment duration.
What to know before you search
Eligibility typically depends on DVT location and severity, time since diagnosis, bleeding risk, kidney function, and whether this is a first or recurrent clot.
What types of trials are currently open
- Anticoagulation trials — Testing different blood thinners, doses, or treatment durations to prevent recurrent clots while minimizing bleeding risk.
- Catheter intervention trials — Studies of devices that remove or dissolve clots directly in the vein, typically for extensive DVT in the upper leg or pelvis.
- Prevention trials — Testing strategies to prevent DVT in high-risk groups such as surgery patients, cancer patients, or people on long flights.
- Post-thrombotic syndrome trials — Testing compression stockings, exercises, or other interventions to reduce chronic leg swelling and pain after DVT.
- Biomarker studies — Following people after DVT to identify blood tests or imaging findings that predict recurrence or complications.
Recently added Deep Vein Thrombosis trials
Complete an ultrasound scan of your knee
Quality improvement study with prospective observational design. The study explores the feasibility of testing diagnostic accuracy of an emergency department-performed focused ultrasound scan of the popliteal fossa in detecting symptomatic Baker's cysts, and to evaluate the potential for such follow-ups to conserve radiological resources. Ultimately, this work aims to establish the feasibility and provide the foundational data necessary for a future definitive diagnostic accuracy study.
Receive a stent in your leg vein to treat ulcers
Outcomes of iliac vein stenting with dedicated venous stents in treatment of chronic post-thrombotic venous ulcers Deep vein thrombosis (DVT) affects 1 to 3 individuals per 1000 annually. Among these patients, 20% to 50% may develop post-thrombotic syndrome (PTS), with the likelihood varying based on the extent and location of the thrombus. Notably, despite receiving anticoagulation therapy, 5% to 10% of patients may progress to severe PTS, potentially leading to the development of venous ulcers (Afsha Aurshina, 2018). Chronic venous obstruction (CVO) refers to the impediment of venous flow, typically resulting from either partial or complete blockage of the venous system. This obstruction leads to diminished venous flow and elevated pressure within the affected veins. CVO serves as a broad descriptor for various conditions, including post-thrombotic syndrome (PTS) and nonthrombotic iliac vein lesions (NIVLs). PTS commonly arises as a complication of deep vein thrombosis (DVT), with estimates indicating that up to 50% of patients diagnosed with iliofemoral DVT will develop PTS within two years following their initial diagnosis. (Mohammad E. Barbati, 2024) The study aims to know the outcomes of iliac vein stenting with dedicated venous stenting in the treatment of post-thrombotic syndrome venous ulcer. Type of Study: Prospective single arm cohort study * Study Setting: Ain Shams University hospitals * Study Period: 2 years with 6 months follow up * Sample Size: 20 patients. * Study Population Patients presenting to the outpatient clinic at Ain Shams University Hospitals with venous ulcers. * Study Tools * 20 patients will be selected. * Written informed consent. * Full history taking, personal history , risk factors of DVT, presence of any medical illness , assessment of QOL based on CVIQ 20 - questionnaire, list of symptoms, sensations or types of discomfort that you may or may not be experiencing and which may make everyday life hard to bear to a greater or lesser extent. * Clinical evaluation: based on revised Venous Clinical Severity Score rVCSS , Villalta score and CEAP classification . rVCSS includes 10 items, such as pain, varicose veins, oedema, skin pigmentation, inflammation, skin induration, number of active ulcers, ulcer size, duration of ulcer, and application of pressure therapy. Each item is scored from 0 to 3 according to the severity, and the total score is 30. A higher score indicates higher severity. And using villlata score It can be used to both diagnose and categories the severity of the condition. The Villalta score involves both the patient who grades the presence and severity (0-3 points) of five symptoms ( pain , cramps, heaviness, parasthesia and pruritus ) and and the physician who grades six clinical signs(Pre-tibial oedema, Hyper-pigmentation, Redness, Venous Ectasia, ain on calf compression, ulcers) (0-3 points) after examination of the lower limb. Also the clinical severity of the venous disease will be graded according to the clinical, etiological, anatomical, and pathophysiological (CEAP) scoring system, and assessment of venous ulcer assessment (by onset, course, duration, site, size, shape
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