Endometrial cancer is the most common gynecologic cancer in the United States, with about 67,000 new cases each year. Most cases are caught early because abnormal bleeding prompts people to see a doctor. Standard treatment is surgery, sometimes followed by radiation or chemotherapy depending on stage and molecular features.
What's actually going on in research
Trials are testing immunotherapy drugs like pembrolizumab and dostarlimab, which have already been FDA-approved for certain endometrial cancers. Researchers are studying targeted drugs for specific mutations (PIK3CA inhibitors, mTOR inhibitors), combinations that add chemotherapy or radiation to immunotherapy, and antibody-drug conjugates. Molecular testing is becoming standard to match tumors to the right treatment.
Immunotherapy combinations
Pembrolizumab and dostarlimab are now approved for mismatch repair-deficient endometrial cancer. Trials are testing whether combining them with chemotherapy works better than chemotherapy alone, especially in advanced disease.
Molecular profiling
Endometrial cancers are now classified by molecular features, not just how cells look under a microscope. This helps predict which tumors will respond to immunotherapy, hormones, or targeted drugs.
Targeted drugs
Drugs that block specific mutations (like PIK3CA or POLE) are being tested for tumors with those changes. Early results suggest some of these may work when standard treatments stop working.
What to know before you search
Eligibility often depends on cancer stage, whether it has spread, prior treatments, and molecular features like mismatch repair status or specific mutations.
What types of trials are currently open
- Immunotherapy trials — Testing checkpoint inhibitors alone or combined with chemotherapy, often for advanced or recurrent cancer.
- Targeted therapy trials — Testing drugs matched to specific mutations found in the tumor, such as PIK3CA or HER2.
- Surgery and radiation trials — Studying whether less surgery or different radiation schedules work as well as current approaches in early-stage disease.
- Combination trials — Testing chemotherapy plus immunotherapy or other drugs to see if combinations work better than single treatments.
- Prevention trials — Studying whether drugs like metformin or weight loss interventions reduce risk in people with Lynch syndrome or obesity.
Recently added Endometrial Cancer trials
Take an experimental cancer drug being tested in adults
DBC-664-ONC-101 is a first-in-human Phase 1a/1b open-label, multicenter study to evaluate the safety, tolerability, PK, pharmacodynamic, and preliminary anti-tumor activity of DBC-664 in patients with endometrial cancer, ovarian cancer, and other advanced solid tumors . This study is divided into 2 parts: Phase-1a Dose Escalation (Part 1), and Phase-1b Dose Expansion (Part 2). In each part, patients who meet specific eligibility criteria will be enrolled.
Try a special diet instead of an enema before surgery
The goal of this clinical trial is to compare a standardized 3-day bowel preparation protocol with a rectal enema before laparoscopic surgery for endometrial cancer. The study will evaluate whether the dietary bowel preparation protocol can be used instead of a rectal enema while maintaining an adequate surgical view during surgery. The main questions it aims to answer are: * Can the dietary bowel preparation protocol provide surgical exposure comparable to a rectal enema? * Can the dietary bowel preparation protocol reduce the minimum Trendelenburg position and pneumoperitoneum pressure required to obtain an adequate surgical view? * Does either bowel preparation method cause more discomfort or side effects before surgery? Researchers will compare a standardized 3-day bowel preparation protocol with a rectal enema before surgery. Participants will: * Be randomly assigned to receive either a standardized 3-day bowel preparation protocol or a rectal enema before surgery. * Undergo standard laparoscopic surgery for endometrial cancer. * Have surgical exposure, the minimum Trendelenburg position, the minimum pneumoperitoneum pressure, operative outcomes, postoperative recovery, and bowel preparation-related symptoms and discomfort assessed as part of routine clinical care.
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