Endometriosis affects roughly 1 in 10 women of reproductive age and takes an average of seven years to diagnose. Treatment options have long been limited to hormones and surgery, but newer GnRH antagonist pills and a wave of non-hormonal research are beginning to change that.
What's actually going on in research
Trials are testing GnRH antagonist pills for pain, non-hormonal medications targeting inflammation, surgical techniques that preserve fertility, and treatments for adenomyosis and deep infiltrating endometriosis. Researchers are also studying earlier diagnosis through blood tests and imaging, and the link between endometriosis and chronic pain.
GnRH antagonist pills
Pills like elagolix and relugolix lower estrogen and reduce endometriosis pain without injections. Trials are testing longer-term use with add-back hormones to prevent bone loss.
Non-hormonal options
Many women cannot or do not want hormonal treatment. Trials are testing drugs that target inflammation and pain pathways without altering menstrual cycles or fertility.
Earlier diagnosis
New blood tests, MRI techniques, and pelvic ultrasound approaches are being studied to diagnose endometriosis without surgery, addressing the long delay many women experience.
What to know before you search
Eligibility often depends on confirmed endometriosis (by surgery or imaging), severity of pain, fertility goals, and prior hormonal or surgical treatments.
What types of trials are currently open
- New medication trials — Testing GnRH antagonist pills, hormones, and non-hormonal drugs for endometriosis pain.
- Surgical trials — Comparing surgical techniques and testing fertility-sparing approaches for endometriosis.
- Pain management trials — Testing treatments for chronic pelvic pain and related conditions.
- Diagnostic trials — Testing blood tests and imaging to diagnose endometriosis without surgery.
- Observational studies — Following women with endometriosis to understand long-term outcomes and fertility.
Recently added Endometriosis trials
Impact of Pelvic Pain Podcast
The purpose of this research study is to study the impact of an educational podcast on pelvic pain. If you decide to take part in this research, you may receive the standard treatment for pelvic pain, or you may receive the standard treatment plus access to an educational podcast series. You will be randomly assigned to receive access to the podcast or to receive standard care. If you are assigned to receive access to the podcast, participating in this research will involve listening to a podcast series. All participants will complete three ten-minute online surveys over the course of 6 months. Reasons you may choose to participate in this research are if you want to learn more about pelvic pain and possible benefits of listening to the podcast, such as improved quality of life, reduced stigma, or increased satisfaction with your medical care.
Study on the Outcomes of Patients Treated in Gynecological Emergency Departments for Pelvic Endometriosis or Suspected Pelvic Endometriosis
Adult patients consulting the gynecological emergency department of CHI Créteil during the inclusion period for endometriosis or symptoms suggestive of endometriosis
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