About a third of people with epilepsy have seizures that resist standard medications, and research is expanding well beyond new pills. Implanted devices that detect and stop seizures, gene therapy for specific genetic epilepsies, and minimally invasive laser surgery are all in active trials.
What's actually going on in research
Trials are testing new anti-seizure medications, responsive neurostimulation devices, gene therapy for SCN1A and other genetic epilepsies, the ketogenic diet in adults, and laser ablation for focal epilepsy. Researchers are also studying epilepsy in pregnancy, cannabidiol for new conditions, and ways to predict who will respond to which medication.
Gene therapy
For specific genetic epilepsies like Dravet syndrome and SCN8A, gene therapies in trials aim to fix the underlying problem rather than suppress symptoms. Some early results are dramatic.
Brain stimulation
Implanted devices that detect abnormal brain activity and deliver stimulation can reduce seizures by half or more. Newer systems are smaller and smarter.
Laser ablation
For focal epilepsy where seizures start in one spot, MRI-guided laser surgery can stop them through a tiny incision. Trials are extending it to more candidates.
What to know before you search
Eligibility often depends on seizure type and frequency, prior medications tried, MRI findings, and whether seizures come from one focal area of the brain.
What types of trials are currently open
- New medication trials — Testing anti-seizure drugs aimed at people whose seizures resist current medications.
- Device trials — Studies of responsive neurostimulation, vagus nerve stimulation, and other implanted devices.
- Surgical trials — Testing laser ablation, focused ultrasound, and traditional epilepsy surgery.
- Gene therapy trials — Studies of gene therapies for specific genetic epilepsies like Dravet syndrome.
- Lifestyle and behavior trials — Testing the ketogenic diet, sleep programs, and stress reduction for seizure control.
Recently added Epilepsy trials
Phenotypic Exploration During Sensory Stimulation in an Acoustic Chamber
An observational behavioural and neurophysiological study of the effects of controlled sensory stimulation (such as music, for example) on brain function
ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome
The primary purpose of this study is to evaluate the safety and tolerability of ION337 in participants with Dravet syndrome (DS).
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