Hyperthyroidism happens when the thyroid gland produces too much thyroid hormone, causing symptoms like rapid heartbeat, weight loss, anxiety, and heat intolerance. The most common cause is Graves' disease, an autoimmune condition. Treatment usually involves antithyroid medications, radioactive iodine, or surgery, with most people managing well on existing options.
What's actually going on in research
Current trials focus on treating Graves' eye disease, which can persist even after thyroid hormone levels are controlled. Researchers are testing monoclonal antibodies that target the immune system differently than existing treatments. Studies also explore better ways to predict which people will go into remission with medication, and new approaches to thyroid nodules that cause hyperthyroidism.
Graves' eye disease treatments
Teprotumumab, an antibody targeting IGF-1 receptor, received FDA approval in 2020 for active Graves' eye disease. Trials are now testing whether it works for milder cases and whether other antibodies can achieve similar results with fewer infusions.
Predicting remission
Studies are identifying biomarkers that might predict which people with Graves' disease will stay in remission after stopping antithyroid drugs. This could help people avoid radioactive iodine or surgery if their disease is likely to resolve.
What to know before you search
Eligibility typically depends on thyroid hormone levels, whether Graves' disease or nodules are the cause, presence of eye disease, and prior treatments received.
What types of trials are currently open
- Graves' eye disease trials — Testing antibody treatments and other therapies for the eye problems that can accompany Graves' disease, including bulging eyes and double vision.
- Treatment comparison trials — Comparing antithyroid medications, radioactive iodine, and surgery to see which works best for different groups of people.
- Biomarker studies — Looking for blood markers or genetic patterns that predict whether hyperthyroidism will come back after treatment stops.
- Nodule treatment trials — Testing less invasive options for thyroid nodules that cause hyperthyroidism, such as radiofrequency ablation or ethanol injection.
- Quality of life studies — Measuring how hyperthyroidism and its treatments affect daily life, work capacity, and mental health over time.
Recently added Hyperthyroidism trials
Take a targeted therapy being tested for thyroid eye disease
The goal of this clinical trial is to evaluate the efficacy, safety, and tolerability of linsitinib in participants with moderate to severe Thyroid Eye Disease (TED).
Track your heart rhythm with a wristband after thyroid surgery
The goal of this observational study is to determine whether nighttime heart rate and heart rhythm data collected by a smart wristband can identify under- or over-replacement with levothyroxine before the routine 1-month thyroid function tests in adults who have undergone total thyroidectomy. After total thyroidectomy, patients usually start levothyroxine replacement therapy, and the dose is adjusted about 1 month later based on thyroid function tests. This study aims to determine whether changes in nighttime heart rate and heart rhythm can provide an earlier indication that the levothyroxine dose is too low or too high. The main questions it aims to answer are: Can nighttime heart rate and heart rhythm measured by a smart wristband identify under- or over-replacement with levothyroxine before routine thyroid function testing? How well do smart wristband measurements agree with thyroid function test results? Participants will: Wear a smart wristband after total thyroidectomy. Continue taking levothyroxine as prescribed by their physician. Undergo routine thyroid function testing approximately 1 month after surgery as part of standard clinical care. Allow researchers to compare smart wristband measurements with thyroid function test results to evaluate whether wearable data can provide an earlier indication of inadequate or excessive levothyroxine replacement.
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