Hypothyroidism means the thyroid gland doesn't make enough thyroid hormone. About 5% of people in the U.S. have it, most commonly women over 60. Standard treatment is levothyroxine, a daily pill that replaces the missing hormone. Most people do well on this, though some continue to have symptoms despite normal blood tests.
What's actually going on in research
Trials are testing combination therapies that add T3 hormone to the standard T4-only levothyroxine, different formulations of thyroid hormone replacement, and treatments for people whose symptoms persist despite normal TSH levels. Researchers are also studying whether selenium or other supplements help specific groups, and what drives ongoing fatigue in people with treated hypothyroidism.
Combination T4-T3 therapy
Some trials compare levothyroxine alone to pills containing both T4 and T3, the two forms of thyroid hormone. The goal is to see if adding T3 helps people whose symptoms persist on standard treatment.
Persistent symptoms research
Studies are looking at why some people with normal thyroid blood tests still have fatigue, weight changes, or brain fog. Researchers are testing whether different dosing strategies or additional treatments can help.
What to know before you search
Eligibility typically depends on TSH level, whether you're already on thyroid medication, and specific symptoms you're experiencing.
What types of trials are currently open
- Treatment comparison trials — Testing levothyroxine against combination T4-T3 pills or different formulations to see which works better for quality of life and symptoms.
- Subclinical hypothyroidism trials — Studying whether people with mildly elevated TSH benefit from treatment, since current guidelines vary on when to start medication.
- Symptom management trials — Testing treatments specifically for fatigue, weight, or cognitive symptoms in people whose thyroid levels are already controlled.
- Observational studies — Following people with hypothyroidism over time to understand what factors predict persistent symptoms and treatment response.
Recently added Hypothyroidism trials
Take a natural thyroid extract tablet daily
The North Star study is a multi-center, Phase 3, open-label, single-arm clinical study to evaluate the Efficacy and Safety of North Star therapy.
Track your heart rhythm with a wristband after thyroid surgery
The goal of this observational study is to determine whether nighttime heart rate and heart rhythm data collected by a smart wristband can identify under- or over-replacement with levothyroxine before the routine 1-month thyroid function tests in adults who have undergone total thyroidectomy. After total thyroidectomy, patients usually start levothyroxine replacement therapy, and the dose is adjusted about 1 month later based on thyroid function tests. This study aims to determine whether changes in nighttime heart rate and heart rhythm can provide an earlier indication that the levothyroxine dose is too low or too high. The main questions it aims to answer are: Can nighttime heart rate and heart rhythm measured by a smart wristband identify under- or over-replacement with levothyroxine before routine thyroid function testing? How well do smart wristband measurements agree with thyroid function test results? Participants will: Wear a smart wristband after total thyroidectomy. Continue taking levothyroxine as prescribed by their physician. Undergo routine thyroid function testing approximately 1 month after surgery as part of standard clinical care. Allow researchers to compare smart wristband measurements with thyroid function test results to evaluate whether wearable data can provide an earlier indication of inadequate or excessive levothyroxine replacement.
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