Hypothyroidism means the thyroid gland doesn't make enough thyroid hormone. About 5% of people in the U.S. have it, most commonly women over 60. Standard treatment is levothyroxine, a daily pill that replaces the missing hormone. Most people do well on this, though some continue to have symptoms despite normal blood tests.
What's actually going on in research
Trials are testing combination therapies that add T3 hormone to the standard T4-only levothyroxine, different formulations of thyroid hormone replacement, and treatments for people whose symptoms persist despite normal TSH levels. Researchers are also studying whether selenium or other supplements help specific groups, and what drives ongoing fatigue in people with treated hypothyroidism.
Combination T4-T3 therapy
Some trials compare levothyroxine alone to pills containing both T4 and T3, the two forms of thyroid hormone. The goal is to see if adding T3 helps people whose symptoms persist on standard treatment.
Persistent symptoms research
Studies are looking at why some people with normal thyroid blood tests still have fatigue, weight changes, or brain fog. Researchers are testing whether different dosing strategies or additional treatments can help.
What to know before you search
Eligibility typically depends on TSH level, whether you're already on thyroid medication, and specific symptoms you're experiencing.
What types of trials are currently open
- Treatment comparison trials — Testing levothyroxine against combination T4-T3 pills or different formulations to see which works better for quality of life and symptoms.
- Subclinical hypothyroidism trials — Studying whether people with mildly elevated TSH benefit from treatment, since current guidelines vary on when to start medication.
- Symptom management trials — Testing treatments specifically for fatigue, weight, or cognitive symptoms in people whose thyroid levels are already controlled.
- Observational studies — Following people with hypothyroidism over time to understand what factors predict persistent symptoms and treatment response.
Recently added Hypothyroidism trials
Understanding the Subnormal Rescue ofNeurological Development in Congenital Hypothyroidism (2022E5SZEM)
Congenital hypothyroidism (CH) is a condition present at birth in which the thyroid gland does not produce enough thyroid hormones. These hormones are essential for normal brain development. Although early diagnosis through newborn screening and treatment with thyroid hormone help prevent serious learning difficulties, some children with CH may still experience difficulties with thinking, learning, or development. This study aims to understand why some children with CH do not achieve the expected level of neurological and cognitive development despite early treatment. The researchers will study 39 patients with CH and compare them with 39 similar individuals without the condition. They will also study 50 children with mild neonatal hyperthyrotropinemia (MNH), a condition involving mildly elevated thyroid-stimulating hormone levels, and compare them with 50 children without the condition. The study will assess medical information, growth measurements, and cognitive test results. Genetic testing will be used to identify changes in genes that may affect thyroid function or brain development. The researchers will also examine chemical changes that regulate how genes work, known as epigenetic changes, and analyze blood samples to identify differences in substances involved in the body's metabolism. By combining these findings, the study aims to identify factors associated with less favorable developmental outcomes and potential markers that may help identify children at risk. The results may improve understanding of congenital thyroid disorders and support earlier recognition of children who may need additional assessment or individualized care.
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation. Numerous studies have reported an association between elevated body mass index (BMI) and periodontitis, particularly among younger and working-age populations. However, data regarding Thai adults under the age of 60 remain limited. Therefore, this study aims to determine the prevalence of high BMI and periodontitis among Thai adults aged 18-59 years and to identify factors associated with these conditions. The findings may provide useful information for improving awareness and supporting the prevention of both periodontal and general health problems in this population.
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