Hypothyroidism means the thyroid gland doesn't make enough thyroid hormone, slowing metabolism and causing fatigue, weight gain, and cold sensitivity. Levothyroxine, a synthetic thyroid hormone pill taken daily, works well for most people. About 5% of adults in the U.S. have hypothyroidism, most often from autoimmune thyroiditis or thyroid removal.
What's actually going on in research
Most trials focus on optimizing levothyroxine dosing, testing combination therapies that add T3 hormone for people who don't feel well on levothyroxine alone, and studying why some people have persistent symptoms despite normal lab values. Researchers are also testing new formulations and delivery methods to improve consistency.
Combination T4/T3 therapy
About 10-15% of people on levothyroxine alone still feel tired or foggy. Trials are testing whether adding liothyronine (T3) improves symptoms and quality of life.
Persistent symptoms
Studies are trying to understand why some people with normal thyroid labs still have symptoms. Researchers are looking at brain thyroid hormone levels, genetic differences in hormone processing, and other factors.
What to know before you search
Eligibility typically depends on thyroid lab values, current levothyroxine dose, symptom severity, and whether you have other thyroid conditions like thyroid nodules or cancer.
What types of trials are currently open
- Dosing studies — Testing different levothyroxine doses or timing to see what achieves the best lab values and symptom relief.
- Combination therapy trials — Comparing levothyroxine alone to levothyroxine plus liothyronine to see if adding T3 helps people who don't feel well on standard treatment.
- Formulation trials — Testing liquid levothyroxine, soft gel capsules, or other forms to improve absorption and reduce dose variability.
- Quality of life studies — Following people with hypothyroidism to understand which symptoms most affect daily life and what predicts good outcomes.
Recently added Hypothyroidism trials
An Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of North Star Desiccated Porcine Thyroid Extract Tablets.
The North Star study is a multi-center, Phase 3, open-label, single-arm clinical study to evaluate the Efficacy and Safety of North Star therapy.
Track your heart rhythm with a wristband after thyroid surgery
The goal of this observational study is to determine whether nighttime heart rate and heart rhythm data collected by a smart wristband can identify under- or over-replacement with levothyroxine before the routine 1-month thyroid function tests in adults who have undergone total thyroidectomy. After total thyroidectomy, patients usually start levothyroxine replacement therapy, and the dose is adjusted about 1 month later based on thyroid function tests. This study aims to determine whether changes in nighttime heart rate and heart rhythm can provide an earlier indication that the levothyroxine dose is too low or too high. The main questions it aims to answer are: Can nighttime heart rate and heart rhythm measured by a smart wristband identify under- or over-replacement with levothyroxine before routine thyroid function testing? How well do smart wristband measurements agree with thyroid function test results? Participants will: Wear a smart wristband after total thyroidectomy. Continue taking levothyroxine as prescribed by their physician. Undergo routine thyroid function testing approximately 1 month after surgery as part of standard clinical care. Allow researchers to compare smart wristband measurements with thyroid function test results to evaluate whether wearable data can provide an earlier indication of inadequate or excessive levothyroxine replacement.
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