Multiple sclerosis treatment now includes more than 20 disease-modifying therapies, ranging from injections to pills to twice-yearly infusions. Many people with relapsing MS now go years without new attacks, and research is shifting attention to progressive forms and to repairing damage already done.
What's actually going on in research
Trials are testing BTK inhibitors that may reach progressive MS, remyelinating drugs that aim to rebuild the damaged nerve coating, stem cell transplant for aggressive disease, and new approaches to fatigue and cognitive symptoms. Researchers are also studying the role of Epstein-Barr virus, which appears to trigger MS in many people.
BTK inhibitors
A new class of pills crosses into the brain and may calm MS at a deeper level than current drugs. Trials are testing whether they can slow progressive forms of MS.
Remyelination therapies
Several drugs aim to rebuild the myelin coating damaged by MS. If successful, they could restore function rather than just prevent new attacks.
Stem cell transplant
Hematopoietic stem cell transplant can reset the immune system in people with aggressive MS. Studies are comparing it to high-efficacy drugs like alemtuzumab.
What to know before you search
Eligibility often depends on MS type (relapsing or progressive), recent activity on MRI, prior treatments, disability level, and sometimes biomarkers or genetic factors.
What types of trials are currently open
- Treatment trials — Testing new MS medications, often pills or longer-acting infusions, to see if they prevent attacks better than current drugs. Many compare against active comparators like ocrelizumab or natalizumab.
- Disease-modifying trials — Testing drugs aimed at slowing or stopping progressive MS, where options have been limited. These trials measure disability progression over one to three years.
- Stem cell trials — Studies of hematopoietic stem cell transplant for aggressive or treatment-resistant MS. These involve chemotherapy to clear the immune system, then reintroduction of your own stem cells.
- Symptom trials — Testing treatments for fatigue, walking problems, bladder symptoms, and cognitive issues. These aim to improve daily function even when disease activity is controlled.
- Repair and remyelination trials — Testing drugs that may rebuild damaged myelin or protect nerves. These could restore lost function in people with existing disability.
Recently added Multiple Sclerosis trials
Track your neuroimmune disease health during pregnancy over five years
Neuroimmune diseases are more prevalent among women of reproductive age. Studies have shown that neuroimmune diseases may impact fertility. Therefore, effective management of neuroimmune diseases during pregnancy is particularly important. This study included a follow-up period of up to five years in patients with pregnancy-associated neuroimmune disorders. Data collected included relapse frequency, symptomatology, imaging findings, treatment regimens, peripheral blood profiles, EDSS scores, and MRI results. In addition, maternal drug concentrations, postpartum relapse rates, and neonatal development were monitored after delivery. Following the successful completion of the five-year follow-up, the research team plans to continue the prospective epidemiological study with ten-year follow-up phases. The aim of this study is to generate detailed clinical data on pregnancy-associated autoimmune diseases and to equip clinicians with evidence-based strategies for optimizing disease management during the reproductive age.
Spinal Alignment, Spinal Mobility, and Balance in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal degeneration. Neuromuscular impairments associated with MS, including muscle weakness, spasticity, fatigue, and proprioceptive deficits, may lead to alterations in spinal posture and reduced spinal mobility. These changes can negatively affect trunk control, balance, respiratory function, and functional independence. Although postural abnormalities and mobility limitations have been reported in individuals with MS, the relationship between spinal posture, spinal mobility, and balance remains insufficiently investigated. Therefore, this study aims to examine the associations between spinal posture, spinal mobility, and balance performance in individuals with multiple sclerosis. Improved understanding of these relationships may contribute to the development of targeted rehabilitation interventions aimed at enhancing postural control and functional outcomes in this population. This study further hypothesises that alterations in spinal posture and spinal mobility are associated with impaired balance performance in individuals with multiple sclerosis.
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