Most prostate cancers grow slowly and many men can safely choose active surveillance instead of immediate treatment. For aggressive or advanced disease, hormone-blocking drugs combined with newer agents have substantially extended life, and a new class of targeted radiation drugs is reaching men whose cancer has spread to bone.
What's actually going on in research
Trials are testing PSMA-targeted radiation drugs earlier in treatment, hormone-therapy combinations for high-risk localized disease, and PARP inhibitors for men with BRCA or other DNA-repair mutations. Research also focuses on which men can safely defer treatment, focal therapy that treats only the cancerous part of the prostate, and better imaging to guide decisions.
PSMA-targeted therapy
Drugs that home in on a protein called PSMA on prostate cancer cells deliver radiation directly to tumors, including in bone. Trials are moving these treatments to earlier stages.
Active surveillance
For low-risk prostate cancer, careful monitoring with PSA tests, MRI, and biopsies avoids surgery and radiation for years or permanently. Trials are refining how to do this safely.
Genetic-guided treatment
Testing tumors and inherited DNA can identify men who benefit from PARP inhibitors or platinum chemotherapy. Several trials enroll based on these mutations.
What to know before you search
Eligibility often depends on PSA level, Gleason score, stage, prior treatments, and sometimes inherited or tumor mutations like BRCA1, BRCA2, or other DNA-repair genes.
What types of trials are currently open
- Treatment trials — Testing new drugs or combinations in men with prostate cancer to see if they work better than standard hormone or chemotherapy treatment.
- Active surveillance studies — Following men with low-risk prostate cancer to refine how often to monitor and when to treat.
- Surgical trials — Comparing surgery, radiation, and focal treatments that target only the cancerous part of the prostate.
- Adjuvant trials — Testing treatments given after surgery or radiation to lower the chance of recurrence.
- Supportive care trials — Testing ways to manage hot flashes, bone loss, and sexual side effects of hormone therapy.
Recently added Prostate Cancer trials
Low to Moderate Load Power Training for Men With Metastatic Prostate Cancer.
The goal of this clinical trial is to learn if a low to moderate load power training program is feasible and effective for improving fitness and quality of life of people with prostate cancer under androgen suppression therapy and bone or lymph node metastasis. The main questions it aims to answer are: * Does a low to moderate load power training program improve quality of life in people with metastatic prostate cancer under androgen deprivation therapy? * Does a low to moderate load power training program improve power, strength, endurance, and balance in people with metastatic prostate cancer under androgen deprivation therapy? Researchers will compare the exercise program with routine care to see if power training works to improve common physical side effects of androgen suppression therapy in patients with metastatic prostate cancer. Participants will: * Participate in a supervised exercise program twice a week for 6 months or maintain routine care. * Perform fitness tests and questionnaires about quality of life and mental health. * Those who take part in the exercise program will also perform semi-structured in-depth interviews after the end of the program.
A Study to Investigate the Safety and Tolerability of Oral INR731 Single Agent or in Combination With Androgen Receptor Pathway Inhibitor (ARPI) in Patients With Metastatic Prostate Cancer
The purpose of this study is to assess the safety, tolerability, pharmacokinetics/pharmacodynamics, preliminary anti-tumor activity, and recommended dose of INR731 as a single agent and in combination with standard-of-care androgen receptor pathway inhibitors (ARPIs) in adult patients with metastatic prostate cancer.
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