What the trial was testing
The ADAURA Trial enrolled 682 patients with lung cancer. The study was sponsored by AstraZeneca and tracked outcomes across the full group of patients who matched the trial's eligibility profile.
It was a large trial designed to confirm whether the treatment works well enough for wider use. Trials at this stage are designed to produce evidence regulators and physicians can act on — not just observations to follow up later.
What the results showed
80% reduction in recurrence risk for early-stage EGFR-mutated lung cancer after surgery.
New England Journal of Medicine · 2023 · NCT02453906
These findings — that in cancer recurrence risk for early-stage EGFR-mutated lung cancer after surgery — were published in the New England Journal of Medicine and represent the headline result of the study.
Researchers tracked outcomes across 682 patients enrolled in the trial. The result was consistent enough across the group that the team felt confident reporting it.
What this means for patients
For patients with lung cancer, this result changes the calculus on what to ask their care team about. Whether it changes day-to-day care depends on factors like disease subtype, prior treatments, and where the patient is in their care journey.
What you can do now
Osimertinib (Tagrisso) is FDA-approved for this indication and available now. If you had surgery for early-stage EGFR-mutated lung cancer, ask your oncologist about adjuvant osimertinib. Eligibility requires confirmed EGFR mutation (exon 19 deletion or exon 21 L858R).
Eligibility for the treatments mentioned above depends on specific test results and clinical history. Bring this summary, the trial name, and your most recent labs or pathology report to your next visit.
Open lung cancer trials
Munich ME/CFS Cohort Study
The Munich cohort study MUC-CFS aims at the characterization and long-term follow-up of myalgic encephalitis/chronic fatigue syndrome (ME/CFS) in young people aged up to 25 years, as well as at the identification of pathomechanisms, biomarkers, and targets for future treatment approaches.
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
The purpose of ARTEMIDE-Lung02 is to assess the efficacy and safety of rilvegostomig in combination with platinum-based chemotherapy for the first-line (1L) treatment of patients with locally advanced or metastatic squamous non-small cell lung cancer (mNSCLC) whose tumors express programmed death-ligand 1 (PD-L1).