What the trial was testing
The trial enrolled 1,648 patients with migraine. The study was sponsored by Pfizer and tracked outcomes across the full group of patients who matched the trial's eligibility profile.
It was a large trial designed to confirm whether the treatment works well enough for wider use. Trials at this stage are designed to produce evidence regulators and physicians can act on — not just observations to follow up later.
What the results showed
20% pain-free at 2 hours on rimegepant vs. 11% on the inactive tablet.
The Lancet Neurology · 2023 · NCT04574362
These findings — that pain-free at 2 hours after a single dose of rimegepant for migraine — were published in the The Lancet Neurology and represent the headline result of the study.
Researchers tracked outcomes across 1,648 patients enrolled in the trial. The result was consistent enough across the group that the team felt confident reporting it.
What this means for patients
For patients with migraine, this result changes the calculus on what to ask their care team about. Whether it changes day-to-day care depends on factors like disease subtype, prior treatments, and where the patient is in their care journey.
What you can do now
Rimegepant (Nurtec ODT) is FDA-approved and available now for treating migraine attacks and for short-term migraine prevention. Side effects are minimal — mostly mild nausea. Ask a neurologist or primary care doctor about adding it as a rescue option.
Eligibility for the treatments mentioned above depends on specific test results and clinical history. Bring this summary, the trial name, and your most recent labs or pathology report to your next visit.
Open migraine trials
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal fluid, blood products, genetics, and patient phenotypes that might help explain this process.
Association of Helicobacter Pylori Infection and Migraine
The study aims to assess the relation between migraine and H pylori infection in children and adolescent.