Urinary incontinence — involuntary urine leakage — affects one in three women and many older men, and it is dramatically underreported and undertreated. It comes in several types: stress incontinence triggered by exertion, urgency incontinence from bladder overactivity, and mixed forms.
What's actually going on in research
Vibegron and mirabegron, beta-3 adrenergic agonists, offer overactive bladder treatment with fewer dry-mouth side effects than older medications. Sacral neuromodulation devices and posterior tibial nerve stimulation are being refined and compared in head-to-head trials. Pelvic floor muscle training delivered by physiotherapist, app, or biofeedback device remains the gold standard for stress incontinence, and trials are testing optimized delivery methods.
Beta-3 agonists
Drugs like vibegron relax the bladder muscle to reduce urgency and leakage with fewer side effects than anticholinergics. Trials are testing them in older adults and special populations.
Sacral neuromodulation
Implanted devices that modulate the sacral nerve controlling the bladder are being compared with medication and with less invasive posterior tibial nerve stimulation in larger trials.
Pelvic floor therapy optimization
Trials are comparing in-person pelvic floor physiotherapy, biofeedback-assisted home programs, and app-guided training for long-term improvement in stress incontinence.
What to know before you search
Eligibility depends on incontinence type (stress, urgency, mixed), episode frequency, prior pelvic surgery, hormonal status, and age.
What types of trials are currently open
- Drug trials — Testing new or improved bladder medications for urgency and mixed urinary incontinence.
- Device trials — Comparing sacral neuromodulation, tibial nerve stimulation, and pessary devices.
- Behavioral trials — Testing pelvic floor muscle training delivery formats, biofeedback, and bladder training programs.
- Surgical trials — Evaluating midurethral slings, urethral bulking agents, and autologous fascial slings.
- Observational studies — Tracking long-term outcomes and treatment persistence across therapies.
Recently added Urinary Incontinence trials
Comparative Effects of Hypopressive Exercises and Paula Method in Postpartum Women.
This study will be a randomized clinical trial with a sample size of 60 postpartum females. The setting of the study will be Bilal Medicare, Sargodha. 60 postpartum women will be included based on age, parity, mode of delivery and type of urinary incontinence. Women with primary gravida, cesarean section and urge and mixed urinary incontinence will be excluded. This study aims to compare the effectiveness of Hypopressive Exercises and the Paula Method in improving urinary incontinence severity, pelvic floor muscle strength and quality of life in postpartum women. Patients of both groups receive two treatment sessions per week over an 8-week period. Group A will be given Hypopressive exercise and Group B will be given Paula exercise protocol. Both groups will perform a standardized kegel exercises for pelvic floor muscle activation and strengthening as baseline treatment followed by their assigned interventions.
Development and Validation of a Risk Prediction Model for De Novo Stress Urinary Incontinence After Pelvic Floor Reconstruction Surgery
This observational study aims to develop a predictive model for the occurrence of new-onset stress urinary incontinence (SUI) after pelvic organ prolapse (POP) repair surgery in women. The primary questions it seeks to answer are: Which risk factors and anatomical characteristics predispose women to new-onset stress urinary incontinence following pelvic organ prolapse repair surgery? Female POP patients without any preoperative symptoms of urinary incontinence will receive telephone follow-ups at 3, 6, and 12 months after undergoing standard surgical treatment.
Find Urinary Incontinence trials matched specifically to you
Answer 3 quick questions and we'll show you trials that fit your situation.