Uterine fibroids are noncancerous growths in the uterus that affect up to 80% of women by age 50. They can cause heavy bleeding, pain, and fertility problems, though many women have no symptoms. Treatment has expanded beyond hysterectomy to include medications that shrink fibroids, minimally invasive procedures, and focused ultrasound.
What's actually going on in research
Trials are testing GnRH antagonists and receptor modulators that shrink fibroids with fewer menopausal side effects, combination approaches pairing medication with procedures, and drugs targeting the blood supply that feeds fibroid growth. Researchers are also studying genetic factors that make some women more susceptible and whether certain medications can prevent fibroids from forming in the first place.
GnRH receptor antagonists
Elagolix, relugolix, and similar drugs lower estrogen without full menopause symptoms and can shrink fibroids significantly. Trials are testing them in combination with hormones to balance symptom relief and bone protection.
Fibroid prevention
Studies are testing whether starting treatment earlier in younger women at high risk can prevent fibroids from growing large. This could spare many women from needing surgery later.
Combination approaches
Researchers are pairing medications with procedures like uterine artery embolization to see if combining treatments provides longer-lasting results. Some trials test medication before surgery to shrink fibroids and reduce blood loss.
What to know before you search
Eligibility typically depends on fibroid size and location, symptom severity, desire for future pregnancy, and whether you've tried other treatments.
What types of trials are currently open
- Medication trials — Testing new drugs that shrink fibroids or reduce bleeding, often comparing them to existing options like GnRH agonists or tranexamic acid.
- Procedure trials — Studying minimally invasive techniques like focused ultrasound, radiofrequency ablation, or new embolization methods that destroy fibroids without surgery.
- Combination trials — Testing whether pairing medication with procedures improves outcomes or reduces the chance fibroids will grow back.
- Quality of life studies — Following women with fibroids to measure how different treatments affect bleeding, pain, fertility, and overall well-being.
- Prevention studies — Testing whether starting treatment early in high-risk women can prevent fibroids from developing or growing large.
Recently added Uterine Fibroids trials
Share your surgical records to help predict hysterectomy outcomes
Uterine fibroids are the most common benign tumors in women of reproductive age and are a major indication for hysterectomy. This retrospective, single-center observational study aims to identify factors associated with the success or failure of vaginal natural orifice transluminal endoscopic surgery (v-NOTES) hysterectomy for large and very large uteri. Approximately 50 adult women who underwent v-NOTES hysterectomy for a large uterus at Strasbourg University Hospitals between January 1, 2024, and December 31, 2025, will be included. Data will be extracted retrospectively from medical records. The primary outcome is successful completion of the v-NOTES procedure without conversion to another surgical approach. Potential predictive factors include body mass index, parity, uterine weight, fibroid location, adenomyosis, vaginal access, previous cesarean deliveries or pelvic surgery, and preoperative medical treatments intended to reduce uterine volume or inflammation. Secondary outcomes include surgical complications, operative duration, length of hospital stay, and unplanned readmission within 30 days of surgery.
Receive a nerve block and sedative medication during gynecologic surgery
Study Objectives This study aims to investigate the effects of preoperative stellate ganglion block and intraoperative intravenous dexmedetomidine on postoperative sleep disturbance in patients undergoing laparoscopic gynecologic surgery, with the goals of reducing pain and postoperative adverse reactions and identifying an effective, safe, economical, and broadly applicable intervention strategy that may facilitate emergence from anesthesia, accelerate postoperative recovery, shorten the length of hospital stay, and reduce hospitalization costs. This trial aims to determine whether preoperative stellate ganglion block (SGB) and intraoperative intravenous dexmedetomidine (DEX) can improve postoperative sleep quality in patients undergoing laparoscopic gynecologic surgery, and whether the combination of these two interventions provides an interaction effect or additional ben
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