Uterine fibroids are benign tumors in the uterus that affect most women by age 50. They can cause heavy bleeding, pain, and pressure symptoms. Treatment options include hormonal medications, procedures that shrink or remove fibroids while preserving the uterus, and hysterectomy for severe cases.
What's actually going on in research
Trials are testing oral GnRH antagonists that shrink fibroids without injection-based hormones, newer progesterone receptor modulators with better side effect profiles, and non-hormonal approaches that target fibroid growth pathways directly. Studies are also refining minimally invasive procedures like radiofrequency ablation and investigating why Black women develop larger and more symptomatic fibroids.
Oral GnRH antagonists
Daily pills like relugolix have replaced monthly injections for shrinking fibroids before surgery or as standalone treatment. Trials are testing how long women can safely stay on these medications.
Non-hormonal targeted therapies
Researchers are testing drugs that block specific growth factors driving fibroid cells, aiming to shrink tumors without affecting reproductive hormones. These could offer options for women who can't tolerate hormonal treatments.
Racial disparity research
Studies are investigating genetic and environmental factors behind the higher fibroid burden in Black women. Understanding these mechanisms could lead to more personalized prevention and treatment approaches.
What to know before you search
Eligibility typically depends on fibroid size and location, symptom severity, desire for future pregnancy, and whether prior treatments have been tried.
What types of trials are currently open
- Medical treatment trials — Testing new medications, usually pills or injections, to shrink fibroids and reduce bleeding without surgery.
- Minimally invasive procedure trials — Studying techniques like radiofrequency ablation or focused ultrasound that destroy fibroids through small incisions or no incisions at all.
- Combination therapy trials — Testing whether pairing medications with procedures leads to better long-term results than either approach alone.
- Quality of life studies — Comparing how different treatments affect bleeding, pain, fertility plans, and overall well-being over time.
- Natural history studies — Following women with fibroids to understand which tumors grow, which cause symptoms, and what predicts treatment success.
Recently added Uterine Fibroids trials
Complete ultrasound scans to help develop diagnostic AI
The goal of this observational study is to develop and validate artificial intelligence (AI)-based algorithms that support ultrasound diagnosis of endometriosis, adenomyosis, myometrial masses, uterine malformations, and impaired endometrial receptivity in women aged 18-45 years. The main questions it aims to answer are: Can AI algorithms, applied to standardized transvaginal ultrasound images, accurately detect and classify endometriosis and adenomyosis in real time during routine examination? Can AI-based ultrasound assessment predict the histological dignity of myometrial masses, and the likelihood of successful assisted reproduction (AR/IVF) outcome from endometrial features? Participants attending the Department of Obstetrics and Gynecology, Semmelweis University, with clinical suspicion of endometriosis or adenomyosis, a confirmed myometrial mass scheduled for surgery, a suspected uterine anomaly, or scheduled IVF treatment, will undergo standardized transvaginal ultrasound examination (following the IDEA, MUSA, and IETA protocols) alongside collection of clinical, questionnaire, and, where surgery is performed, histopathological data. Imaging and clinical data will be used to build a database supporting the development and validation of the AI algorithms.
Try a special diet and receive deeper muscle relaxation during vaginal hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision. A clear surgical view is essential, and the main obstacle to the view is bowel falling into the pelvis. This randomized trial tests whether two simple measures improve the surgical field, individually or in combination: a preoperative low-residue diet for three days, and deeper intra-operative muscle relaxation (deep neuromuscular blockade). No group receives mechanical bowel preparation. Using a 2×2 factorial design, participants are allocated equally (1:1:1:1) to one of four groups: (1) no diet with standard relaxation; (2) diet with standard relaxation; (3) no diet with deep relaxation; (4) diet with deep relaxation (the "bundle"). The surgical field is measured objectively: during a standardized window the carbon-dioxide insufflation pressure is lowered step by step, and 2-3 blinded assessors score the field from de-identified video. The primary outcome is the lowest pressure at which the field remains adequate; a lower pressure indicates an intrinsically better field. The trial hypothesis is an interaction - that the combination achieves an adequate field at a meaningfully lower pressure than either measure alone. The final sample size is determined from an internal pilot. Secondary outcomes include the continuous field score, the need for an additional instrument to clear the field, postoperative nausea and vomiting, and routine operative outcomes.
Find Uterine Fibroids trials matched specifically to you
Answer 3 quick questions and we'll show you trials that fit your situation.