Uveitis is inflammation inside the eye that can blur vision, cause pain, and lead to permanent damage if untreated. It affects about 300,000 people in the United States and has many causes — autoimmune diseases, infections, or sometimes no clear trigger. Treatment typically starts with steroid eye drops or injections, and severe cases may need immune-suppressing drugs.
What's actually going on in research
Trials are testing biologic drugs that target specific immune pathways, including TNF inhibitors like adalimumab (already FDA-approved for some uveitis) and IL-6 blockers. Researchers are also studying longer-acting steroid implants, JAK inhibitors given as pills, and new ways to prevent the vision-threatening complications that happen when inflammation becomes chronic.
Biologic drugs
Adalimumab is now FDA-approved for non-infectious uveitis in adults and children. Trials are testing other biologics to see if they work as well with fewer side effects or better reach certain types of uveitis.
Steroid implants
Devices that sit inside the eye and release steroid slowly over months or years are being refined. They may reduce the need for frequent injections and the side effects of long-term oral steroids.
JAK inhibitors
Pills that block Janus kinases may calm uveitis without injections. Early trials are testing whether they work for people who haven't responded to other treatments.
What to know before you search
Eligibility usually depends on uveitis type (anterior, intermediate, or posterior), whether it's infectious or non-infectious, prior treatments tried, and how well inflammation is controlled.
What types of trials are currently open
- Biologic trials — Testing antibody drugs given by infusion or injection to block specific immune signals that drive inflammation in the eye.
- Implant trials — Testing devices placed inside the eye that release anti-inflammatory medication steadily over months to years.
- Oral medication trials — Testing pills like JAK inhibitors or other immune-modulating drugs that may be easier to take than injections.
- Complication prevention trials — Testing treatments aimed at preventing cataracts, glaucoma, and macular edema that can develop from chronic uveitis.
- Observational studies — Following people with uveitis to understand which types respond best to which treatments and what predicts vision loss.
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