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Donate blood and tissue samples to help researchers understand HIV | stella

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Understanding HIV levels in blood and lymph tissue

Plain-English translation of NCT00001316 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

What is this trial?

Researchers want to understand how HIV behaves differently in various parts of your body—specifically comparing the amount of virus found in your blood versus in lymph nodes and bone marrow. This study will enroll 400 people: some living with HIV and some without. By studying tissue samples alongside blood samples, researchers hope to learn more about how HIV infection develops and spreads.

Scientists have noticed that HIV levels can look very different depending on whether they measure blood or lymphoid tissue, but we don't fully understand why. This research could help doctors better monitor and treat HIV by understanding where the virus actually hides and replicates in the body.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have a confirmed HIV diagnosis (documented by blood test) or are HIV-negative and willing to serve as a comparison participant
you are able to give written informed consent
you have adequate blood cell counts and normal blood clotting ability
you have a lymph node in an easily accessible location that can be felt by a doctor
you are willing to have blood samples used for future HIV research, genetic testing, and hepatitis screening

You likely don't qualify if…

you are pregnant or breastfeeding
you are currently abusing alcohol, narcotics, or cocaine
you have AIDS-related dementia or certain AIDS-related cancers
you have taken aspirin or ibuprofen within the past week (acetaminophen is okay)
you have used narcotics or cocaine within the past week

What participation looks like

You will donate blood samples and have a small tissue sample taken from a lymph node (a biopsy procedure). The study compares people living with HIV to people without HIV to see how virus levels differ between blood and lymphoid tissue. You'll also allow your samples to be used for additional research on HIV and immune function, including genetic and hepatitis testing.

AI-generated summary from trial data · Jul 4, 2026 · Not medical advice

Trial locations(1 site)

United States

National Institutes of Health Clinical Center, Bethesda, Maryland

Key details

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Enrollment target

~400 participants

Started

August 1992

Age range

18 Years – 100 Years

Last updated on clinicaltrials.gov in July 2026.

Contact the research team directly

Reach out to the team running this trial. Response times vary — some teams are faster than others.

Central contact

Catherine A Seamon, R.N.

National Institute of Allergy and Infectious Diseases (NIAID)

Interested in joining?

Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.

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View full record on ClinicalTrials.gov