Plain-English translation of NCT00181259 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers at Johns Hopkins are using a special imaging technique called magnetic resonance spectroscopy to study how the heart muscle uses energy. The study compares energy use in people with healthy hearts, those with enlarged or weakened hearts, and those with blocked coronary arteries. By understanding these differences, doctors hope to learn more about why certain hearts fail and how to treat them better.
Doctors don't fully understand why some hearts fail while others stay healthy, even when they face similar stress. This study aims to fill that gap by directly measuring how different types of hearts process energy, which could lead to better treatments and earlier detection of heart problems.
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You will undergo magnetic resonance imaging (MRI) scans of your heart while resting and possibly during stress testing to measure how your heart muscle uses energy. The exact number of visits and duration of participation is not specified in the trial details, but you should expect to complete imaging scans at a medical facility. You will be grouped based on your heart health status (healthy, heart failure, enlarged heart, or coronary artery disease).
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
United States
National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~500 participants
Started
January 1988
Primary completion
August 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
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Central contact
Robert G. Weiss, MD
Johns Hopkins University
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