Understanding Hormone Imbalance in Children: A Long-Term Study

Plain-English translation of NCT00250159 on ClinicalTrials.gov ↗ · Source last updated September 2026 · Translation generated August 2026 · How we translate trials

What is this trial?

This is a long-term observational study that follows patients with two genetic conditions that cause excess male hormones in childhood: Congenital Adrenal Hyperplasia (CAH) and Familial Male-Limited Precocious Puberty (FMPP). Researchers are collecting detailed information about how these conditions affect growth, development, metabolism, and psychological well-being over time. The study is not testing a new medication, but rather tracking patients to better understand these rare conditions and improve future treatments.

Children with excess male hormones often experience early puberty, accelerated growth, and shorter adult height, but doctors don't fully understand all the ways these conditions affect a patient's body and mind. This study aims to create a comprehensive picture of how these genetic disorders develop and progress, which will help doctors design better treatments in the future.

Do you qualify?

You likely qualify if…

you are a male of any age (0-99 years old) with known or suspected familial male-limited precocious puberty
you have been diagnosed with or are suspected to have congenital adrenal hyperplasia of any type
you have excess male hormones of unknown cause
you are a relative (usually a parent) of someone already enrolled in this study

You likely don't qualify if…

you are a woman whose only diagnosis is polycystic ovary syndrome
you have serious medical conditions unrelated to hormone problems
you are pregnant at the time you would enroll in the study

What participation looks like

Your participation will involve visiting the research clinic or working with your home doctor to provide medical information and allow researchers to collect blood samples and track your growth, development, and hormone levels. Some participants will be managed directly at the National Institutes of Health, while others will participate through their local physicians. The study is ongoing with no set end date, meaning you would be followed over months or years to help doctors understand how these conditions change over time.

AI-generated summary from trial data · Aug 20, 2026 · Not medical advice

Trial locations(2 sites)

United States

Medstar Washington Hospital Center, Washington D.C., District of Columbia

National Institutes of Health Clinical Center, Bethesda, Maryland

Key details

Sponsor

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Enrollment target

~3,000 participants

Started

January 2006

Age range

1 Day – 99 Years

Last updated on clinicaltrials.gov in September 2026.

Contact the research team directly

Reach out to the team running this trial. Response times vary — some teams are faster than others.

Central contact

Deborah P Merke, M.D.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Interested in joining?

Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.

View full record on ClinicalTrials.gov