Plain-English translation of NCT00301119 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Lung Cancer research guide →This research study is looking for biological markers — early warning signs in your blood and lung tissue — that could help doctors detect lung cancer before symptoms appear. Researchers will collect samples and imaging from current smokers, former smokers, and people whose CT scans show possible lung nodules to understand what changes happen in the lungs years before cancer develops.
Lung cancer is often caught late, when it's harder to treat. This study exists to find early detection clues in blood and tissue that could one day help doctors catch the disease much sooner, when treatment is more likely to succeed.
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If you're in the screening group, you'll complete a health questionnaire, have breathing function tests, receive a chest CT scan, provide a sputum sample (coughed-up mucus), and give blood samples. If you're in the second group because of suspicious lung findings, you'll do the same tests, and may also have a bronchoscopy (a thin camera inserted down your airway to look inside your lungs) or surgery with biopsies, depending on what your doctor finds. All of this is observational — researchers are watching and collecting samples, not giving you a new medication or treatment.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
United States
Sponsor
NYU Langone Health
Enrollment target
~3,606 participants
Started
May 2000
Primary completion
May 2030
Age range
50 Years and older
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
James J. Tsay, MD, MSc
NYU Langone Health
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.