Plain-English translation of NCT00692939 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Crohn's Disease research guide →Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a procedure called autologous stem cell transplantation for people with severe Crohn's disease. The treatment involves collecting your own stem cells, giving you high-dose chemotherapy to reset your immune system, and then putting the stem cells back into your body. The goal is to help your immune system stop attacking your intestines and causing inflammation.
Crohn's disease happens when your immune system mistakenly attacks your own intestines, causing chronic inflammation and damage. Standard medications don't work for everyone, and some people face repeated surgeries or serious complications. This trial explores whether resetting your immune system with your own stem cells might offer relief for people whose disease is resistant to current treatments.
You likely qualify if…
You likely don't qualify if…
If you join this trial, you would first undergo screening tests to make sure your heart, lungs, and blood counts are healthy enough. Then you would receive high-dose chemotherapy to suppress your immune system, followed by collection of your own stem cells and their return to your body through infusion. You would stay in the hospital during this intensive phase and have multiple follow-up visits over the following months and years to monitor your recovery and Crohn's disease activity.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States