Plain-English translation of NCT00823654 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →This study is following young women with early-stage breast cancer (or those with a BRCA gene mutation) to understand how cancer treatment affects the ovaries and future fertility. Researchers will measure hormone levels in your blood before, during, and after cancer treatment to see which women might experience early menopause. This information could help doctors better counsel young patients about their options for preserving fertility before starting cancer treatment.
Women with BRCA mutations and young women with breast cancer have higher risks of early menopause and infertility. Doctors need better ways to predict which women are at highest risk so they can discuss fertility preservation options—like egg freezing—before cancer treatment begins.
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You will have blood drawn at multiple time points: before you start cancer treatment, during treatment, and after treatment is finished. You will also complete questionnaires about your menstrual cycle and general health. The study involves visits to a hospital or cancer center, but the main commitment is providing blood samples and filling out forms—there are no medications to take as part of the research itself.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
United States